DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha3 and lgc-5

DIOPT Version :10

Sequence 1:NP_525079.3 Gene:nAChRalpha3 / 31767 FlyBaseID:FBgn0015519 Length:795 Species:Drosophila melanogaster
Sequence 2:NP_501411.4 Gene:lgc-5 / 184620 WormBaseID:WBGene00017543 Length:433 Species:Caenorhabditis elegans


Alignment Length:409 Identity:94/409 - (22%)
Similarity:183/409 - (44%) Gaps:68/409 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MKWFQVTIDMILVLSFISSSTANPDAKR--LYDDLLS-NYNKLVRPVVNVTDALTVRIKLKLSQL 62
            |.|...::...|||....|:|.|.::..  |..:|.: .|:..|:|...:|   ||.|......|
 Worm     1 MSWLLNSLLTFLVLRTFGSNTTNVESNTEVLLQELFNRTYDVNVKPSDTLT---TVTITPNTFLL 62

  Fly    63 IDVNLKNQIMTTNLWVEQ---SWYDYKLKWEPK--EYGGVEMLHVPSDHIWRPDIVLYNNADGNF 122
            :.:   :|...|.|:.::   .|||..|.|...  :|.. |.:.:....:|.||::        |
 Worm    63 LSM---DQTQETILFSQEFLLKWYDPILHWNRTLFDYNR-EWIKISVSRVWVPDVI--------F 115

  Fly   123 EVTLATK---------ATLNYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQV 178
            ...|:.:         |.|.|.|.:....||:..:||.::::.||.|.|.|.:..|||.:|...:
 Worm   116 TKRLSVESLLDEDMQMADLRYNGEIRTSLPAVVSTSCPLNIQDFPHDVQECNISMGSWAFDRTVI 180

  Fly   179 DLRHIDELNGTNVVEVGVD-----LSEFYTSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMR 238
                        ||:..||     ...|..:.||::|.:.|.|.:.|.......:.:||:.:|::
 Worm   181 ------------VVQSSVDEILPLRGRFEGNSEWELLSIRAFRTDSFEYSLGTSFSEITYTVTLQ 233

  Fly   239 RKTLFYTVNLIIPCMGISFLTILVFYLP-SDSGEKVS---LSISILLSLTVFFLLLAEIIPPTSL 299
            ||.::|.:.:..|...:..:||...:.| |:..|::|   |.:::..::::...|:::::|..|.
 Worm   234 RKPVYYVLVIQAPTFILCTITIFGLFSPNSNENERLSRVELCLNMFAAISMMLQLVSDMMPKASR 298

  Fly   300 VVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQTHTMAP-WVRTVFI------------NQLP 351
             :||||.:::..:.:.|.:....:::.::|.......|..| |:|.:.:            :.:.
 Worm   299 -LPLLGNYIIAEIFVVTAATIAAIVIQHVHHHVHTNATCPPKWLRCLVLCDCMREEFPSKTSSVS 362

  Fly   352 RFLVMRRPLYPISEMIKSS 370
            ...|....:.|:| ::|||
 Worm   363 SMDVPENIIAPVS-LLKSS 380

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha3NP_525079.3 LGIC_ECD_nAChR_proto_alpha-like 25..243 CDD:349832 58/239 (24%)
Cys-loop 150..164 CDD:349832 5/13 (38%)
LGIC_TM_nAChR 242..>331 CDD:349866 18/92 (20%)
TM1 helix 242..266 CDD:349866 4/23 (17%)
TM2 helix 274..295 CDD:349866 3/23 (13%)
TM3 helix 306..328 CDD:349866 1/21 (5%)
Neur_chan_memb <683..760 CDD:460753
lgc-5NP_501411.4 LGIC_ECD_cation 51..235 CDD:349790 51/210 (24%)
Cys-loop 152..166 CDD:349790 5/13 (38%)
LGIC_TM 238..>323 CDD:476813 17/85 (20%)
TM1 helix 241..261 CDD:349853 3/19 (16%)
TM2 helix 273..294 CDD:349853 2/20 (10%)
TM3 helix 304..323 CDD:349853 1/18 (6%)
Blue background indicates that the domain is not in the aligned region.

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