DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha3 and lgc-25

DIOPT Version :10

Sequence 1:NP_525079.3 Gene:nAChRalpha3 / 31767 FlyBaseID:FBgn0015519 Length:795 Species:Drosophila melanogaster
Sequence 2:NP_510359.3 Gene:lgc-25 / 181525 WormBaseID:WBGene00010994 Length:502 Species:Caenorhabditis elegans


Alignment Length:533 Identity:120/533 - (22%)
Similarity:222/533 - (41%) Gaps:114/533 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 QVTIDMILVLSFISSSTAN-PDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQL--IDVN 66
            |:.:..|||:..:.:.... ...::|...|:..||..||||.:......|.:.|.::.:  :|.:
 Worm     5 QLLLIGILVIWHLDNQVCGLSKEQQLEKQLMVKYNYKVRPVKSEATVTQVNVFLSIAHVEKVDEH 69

  Fly    67 LKNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGN-FEVTL-ATK 129
            .:..::..::|.  :|.|..::|:.|: ..|..|.:.:..:|:|.:.|||:|.|| :.:.: |..
 Worm    70 EQTALVHGHIWA--TWIDEYMQWDAKK-ENVTKLTISAHSLWQPALALYNSARGNSWHLYMGAMP 131

  Fly   130 ATLNYTGRVEWRPPAI-YKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLR--HIDELNGTNV 191
            ||:..||:| |..... :..:|:.|...:|||:|:|.:....|.|:..||:|.  :|.:..|...
 Worm   132 ATVYSTGKV-WSTGTFSFYVTCQFDFTNWPFDQQSCPIVIADWVYNLNQVNLSDPYILKEYGKPS 195

  Fly   192 VEVG---VDLSEFYTSVEWDIL----------------EVPAVRNEKFYTCCDEPYLDITFNITM 237
            :.:.   ::.|:......|:::                |.|....|.:::.       :.|.|.:
 Worm   196 IRLSYDPIEKSDKRHVAGWEVMDAWKKHCYWGPKGCKEEQPEGEAEWYWSL-------LEFGIIL 253

  Fly   238 RRKTLFYTVNLIIPCMGISFLTILVFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVP 302
            ||...:::::::.|..|.|.:.:|.|::.:.|....::.::|:|.......|||: :||.|...|
 Worm   254 RRHLPYFSLSILFPMAGTSLILLLCFWIETHSICFFTIMLNIILQSYYGSSLLAK-MPPGSGRTP 317

  Fly   303 LLGKFV-LFTMILDTFSICVTVLVLNIHFRSPQTHTMAPWVRTVFINQLPRFLVMRRPLYPISEM 366
               |.| |:.|         .:|:..:.|           |..||    ..||.:|.|       
 Worm   318 ---KIVHLYNM---------NLLLSAVQF-----------VLIVF----SEFLRLRLP------- 348

  Fly   367 IKSSRRLMVRTCNGLELRDQIPPLPPPVALSRMHHSPKTTSRSTS---PHLQHRVQTYNLMDECG 428
             |...         |:|...|..:|....:.::.     |.:..|   ..|...|.:...::|..
 Worm   349 -KKFE---------LDLGFDIIGVPQRFGVDKLF-----TQKGLSFDPQELFSNVYSTRTLEEIL 398

  Fly   429 MGMGGGASTITGHLSSLYPPTMSTANQQTSTTSSLIDAQYHNQYQQTGGSLLDHPLT--PTKFRQ 491
            ...||.:||..|..:.|:...  |:.|::|.:|.|||.                |:|  |..|..
 Worm   399 EQGGGSSSTSVGIGNPLHEDI--TSFQKSSDSSVLIDI----------------PMTSEPQSFSA 445

  Fly   492 MTS--TSSQTGQN 502
            .||  .||:...|
 Worm   446 STSELLSSEPSSN 458

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha3NP_525079.3 LGIC_ECD_nAChR_proto_alpha-like 25..243 CDD:349832 56/243 (23%)
Cys-loop 150..164 CDD:349832 6/13 (46%)
LGIC_TM_nAChR 242..>331 CDD:349866 20/89 (22%)
TM1 helix 242..266 CDD:349866 5/23 (22%)
TM2 helix 274..295 CDD:349866 5/20 (25%)
TM3 helix 306..328 CDD:349866 5/22 (23%)
Neur_chan_memb <683..760 CDD:460753
lgc-25NP_510359.3 LGIC_ECD_cation 52..256 CDD:349790 47/214 (22%)
Cys-loop 152..166 CDD:349790 6/13 (46%)
Blue background indicates that the domain is not in the aligned region.

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