DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha3 and lgc-21

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_510341.2	Gene:	lgc-21 / 181516	WormBaseID:	WBGene00007903	Length:	462	Species:	Caenorhabditis elegans

Alignment Length:	299	Identity:	70/299 - (23%)
Similarity:	117/299 - (39%)	Gaps:	53/299 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 WVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYN------NADGNFEVTLATKATLNYT 135
            ::|.||:|.:|.|....:...:::.....|||.|.:...|      |.|. ||:   .|......
Worm   139 YLELSWHDDRLMWNQDTWKKNKLVVHSFHHIWVPLLGSQNPENHLKNGDA-FEI---RKVETTNQ 199

  Fly   136 GRVEWRPPAIYKSSC-EIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLS 199
            |.|..:.....::.| :.|.|.:|.|...|...|..      |.| |.:.:...:. :.:..|..
Worm   200 GNVSAKVAFSLRTFCDDTDFENYPNDVYKCCFSFEP------QQD-REVIQFTSSG-LPIFTDPK 256

  Fly   200 EFYTSVEWDIL-EVPAVRNEKFYTCCDEP--YLDITFNITMRRKTLFYTVNLIIPCMGISFLTIL 261
            .| ....|.:. .||    |.|    |:|  ...:.|.:.::|......:.|.||.    |:|..
Worm   257 NF-RDYGWGVSGTVP----ESF----DDPSEIAQLGFCLNLKRAHSSLKIELAIPL----FITTA 308

  Fly   262 VFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLG---------KFVLFTMILDTF 317
            :|.||...|   |:.|.|.|.:.|..|....::..::.:.|.|.         :|:...::.:..
Worm   309 LFLLPPLFG---SVKIQIYLKMFVMGLQFMTLLIFSTRIAPFLSSTASTPKPMRFLEIALVFNLI 370

  Fly   318 SICVTVLVLNIHFRSPQT-HTMAPWVR-TVFINQLPRFL 354
            ||..::::    |...|. .|:.||.| |.|.|.:..||
Worm   371 SITTSIII----FCCMQVKRTLPPWGRVTQFANFINGFL 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	39/173 (23%)
		Neur_chan_memb	248..>359	CDD:280999	31/118 (26%)
		Neur_chan_memb	<683..760	CDD:280999
lgc-21	NP_510341.2	LGIC_ECD	113..290	CDD:355788	38/171 (22%)
lgc-21	NP_510341.2	Cys-loop	214..229	CDD:349787	5/14 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810