DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nAChRalpha3 and lgc-4

DIOPT Version :10

Sequence 1:NP_525079.3 Gene:nAChRalpha3 / 31767 FlyBaseID:FBgn0015519 Length:795 Species:Drosophila melanogaster
Sequence 2:NP_509556.4 Gene:lgc-4 / 181155 WormBaseID:WBGene00017580 Length:635 Species:Caenorhabditis elegans


Alignment Length:392 Identity:124/392 - (31%)
Similarity:206/392 - (52%) Gaps:51/392 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 LYDDLLSN--YNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLKWEP 91
            ||..||.:  |.|.|||.::.:....|.....|:|:::::.:||.:||..|:..:|.|.:|.|..
 Worm   114 LYRSLLDHTVYEKDVRPCIHHSQPTNVTFGFLLNQIVEMDERNQALTTRSWLNINWMDPRLSWNE 178

  Fly    92 KEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTL-ATKATLNYTGRVEWRPPAIYKSSCEIDVE 155
            ..:..::.:::|...||:|||:|.|||...:..:| :|...:...|.|.|...|:::|||.|.|.
 Worm   179 SLWSEIKAIYIPHARIWKPDIILVNNAIREYYASLVSTDVMVTSDGNVTWLFSALFRSSCPIRVR 243

  Fly   156 YFPFDEQTCVMKFGSWTYDGFQVDLRHIDELN-GTNVVEVGVDLSEFYTSVEWDILEVPAVRNEK 219
            |:|||:|.|.:||.||::|        |.|:| |.| .:.| |||.:..:.|:|::::.|||...
 Worm   244 YYPFDDQQCDLKFASWSHD--------ITEINLGLN-TDKG-DLSSYMNNSEFDLVDMTAVREVV 298

  Fly   220 FY---TCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSGEKVSLSISILL 281
            .:   |..|.|.  |...|.|.|:.|||..|.|:||:.||.:.:|.|.:|.::|||:::.|:.||
 Worm   299 TFPSDTNSDWPI--IVIRIHMHRRPLFYVFNHIVPCVLISSMAVLGFLMPPETGEKINMIITTLL 361

  Fly   282 SLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFR--SPQTHTMAPWVRT 344
            |:.|:...:.|.|||||..|||:|.:.:.::::...:.||.|:.||:|..  :.|...:..|::.
 Worm   362 SMGVYLQSITESIPPTSEGVPLIGMYYVSSLLMVCLATCVNVITLNMHRNGAANQGRHVPAWMQK 426

  Fly   345 VFINQLPRFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRDQIPPLPPPVALSRMHHSPKTTSRS 409
            ..:..|..|:                 |:.:|.             |..:||.:...|.|:|.|.
 Worm   427 WILGYLATFM-----------------RMSIRE-------------PDSIALLKASQSKKSTIRR 461

  Fly   410 TS 411
            :|
 Worm   462 SS 463

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha3NP_525079.3 LGIC_ECD_nAChR_proto_alpha-like 25..243 CDD:349832 74/220 (34%)
Cys-loop 150..164 CDD:349832 8/13 (62%)
LGIC_TM_nAChR 242..>331 CDD:349866 36/88 (41%)
TM1 helix 242..266 CDD:349866 11/23 (48%)
TM2 helix 274..295 CDD:349866 6/20 (30%)
TM3 helix 306..328 CDD:349866 4/21 (19%)
Neur_chan_memb <683..760 CDD:460753
lgc-4NP_509556.4 LGIC_ECD_nAChR 138..320 CDD:349798 64/193 (33%)
Cys-loop 238..252 CDD:349798 8/13 (62%)
LGIC_TM_cation 322..>409 CDD:349853 35/86 (41%)
TM1 helix 322..346 CDD:349853 11/23 (48%)
TM2 helix 354..375 CDD:349853 6/20 (30%)
TM3 helix 386..408 CDD:349853 4/21 (19%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.