DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha3 and lgc-4

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_509556.4	Gene:	lgc-4 / 181155	WormBaseID:	WBGene00017580	Length:	635	Species:	Caenorhabditis elegans

Alignment Length:	392	Identity:	124/392 - (31%)
Similarity:	206/392 - (52%)	Gaps:	51/392 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LYDDLLSN--YNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLKWEP 91
            ||..||.:  |.|.|||.::.:....|.....|:|:::::.:||.:||..|:..:|.|.:|.|..
Worm   114 LYRSLLDHTVYEKDVRPCIHHSQPTNVTFGFLLNQIVEMDERNQALTTRSWLNINWMDPRLSWNE 178

  Fly    92 KEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTL-ATKATLNYTGRVEWRPPAIYKSSCEIDVE 155
            ..:..::.:::|...||:|||:|.|||...:..:| :|...:...|.|.|...|:::|||.|.|.
Worm   179 SLWSEIKAIYIPHARIWKPDIILVNNAIREYYASLVSTDVMVTSDGNVTWLFSALFRSSCPIRVR 243

  Fly   156 YFPFDEQTCVMKFGSWTYDGFQVDLRHIDELN-GTNVVEVGVDLSEFYTSVEWDILEVPAVRNEK 219
            |:|||:|.|.:||.||::|        |.|:| |.| .:.| |||.:..:.|:|::::.|||...
Worm   244 YYPFDDQQCDLKFASWSHD--------ITEINLGLN-TDKG-DLSSYMNNSEFDLVDMTAVREVV 298

  Fly   220 FY---TCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSGEKVSLSISILL 281
            .:   |..|.|.  |...|.|.|:.|||..|.|:||:.||.:.:|.|.:|.::|||:::.|:.||
Worm   299 TFPSDTNSDWPI--IVIRIHMHRRPLFYVFNHIVPCVLISSMAVLGFLMPPETGEKINMIITTLL 361

  Fly   282 SLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFR--SPQTHTMAPWVRT 344
            |:.|:...:.|.|||||..|||:|.:.:.::::...:.||.|:.||:|..  :.|...:..|::.
Worm   362 SMGVYLQSITESIPPTSEGVPLIGMYYVSSLLMVCLATCVNVITLNMHRNGAANQGRHVPAWMQK 426

  Fly   345 VFINQLPRFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRDQIPPLPPPVALSRMHHSPKTTSRS 409
            ..:..|..|:                 |:.:|.             |..:||.:...|.|:|.|.
Worm   427 WILGYLATFM-----------------RMSIRE-------------PDSIALLKASQSKKSTIRR 461

  Fly   410 TS 411
            :|
Worm   462 SS 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	74/218 (34%)
		Neur_chan_memb	248..>359	CDD:280999	36/112 (32%)
		Neur_chan_memb	<683..760	CDD:280999
lgc-4	NP_509556.4	Neur_chan_LBD	111..321	CDD:280998	74/218 (34%)
lgc-4	NP_509556.4	Neur_chan_memb	329..>457	CDD:280999	42/157 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810