Protein Alignment nAChRalpha3 and acr-16

DIOPT Version :9

• Sequence 1: NP_001285015.1
• Gene: nAChRalpha3 / 31767
• FlyBaseID: FBgn0015519
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: NP_505207.1
• Gene: acr-16 / 179235
• WormBaseID: WBGene00000055
• Length: 498
• Species: Caenorhabditis elegans
• Alignment Length: 742
• Identity: 209/742 - (28%)
• Similarity: 306/742 - (41%)
• Gaps: 270/742 - (36%)

  Fly    27 KRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLKWEP 91
            :|||:||:.|||.|.|||.|.::.:||.:|:.|.|:|||:.|||::..|.|::.:|.||.|.|:.
 Worm    24 RRLYEDLMRNYNNLERPVANHSEPVTVHLKVALQQIIDVDEKNQVVYVNAWLDYTWNDYNLVWDK 88

  Fly    92 KEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVEWRPPAIYKSSCEIDVEY 156
            .|||.:..:..|:..||:||::|||:.|.||:.|..|...:..||.|.|.||.|:|.||:||:::
 Worm    89 AEYGNITDVRFPAGKIWKPDVLLYNSVDTNFDSTYQTNMIVYSTGLVHWVPPGIFKISCKIDIQW 153

  Fly   157 FPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTSVEWDILEVPAVRNEKFY 221
            ||||||.|..|||||||||:::||:   ...|      |.|:||:.::.||.:......||||||
 Worm   154 FPFDEQKCFFKFGSWTYDGYKLDLQ---PATG------GFDISEYISNGEWALPLTTVERNEKFY 209

  Fly   222 TCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSGEKVSLSISILLSLTVF 286
            .||.|||.|:.|.:.|||:||:|..|||:||:..:.:|:|.|.||.|:|||::|.|::|||:..|
 Worm   210 DCCPEPYPDVHFYLHMRRRTLYYGFNLIMPCILTTLMTLLGFTLPPDAGEKITLQITVLLSICFF 274

  Fly   287 FLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQTHTMAPWVRTVFINQLP 351
            ..:::|:.||||..|||||.|....||:.|.|...||.|||:|:|:|:||.|.||.|.:.:..:|
 Worm   275 LSIVSEMSPPTSEAVPLLGIFFTCCMIVVTASTVFTVYVLNLHYRTPETHDMGPWTRNLLLYWIP 339

  Fly   352 RFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRDQIPPLPPPVALSRMHHSPKTTSRSTSPHLQH 416
            ..|.|:||.:.::..                   .:|.|                 .||.|:...
 Worm   340 WILRMKRPGHNLTYA-------------------SLPSL-----------------FSTKPNRHS 368

  Fly   417 RVQTYNLMDECGMGMGGGASTITGHLSSLYPPTMSTANQQTSTTSSLIDAQYH-NQYQQTGGSLL 480
            .....|:.|                            |:.:.:.::..||... |||..|
 Worm   369 ESLIRNIKD----------------------------NEHSLSRANSFDADCRLNQYIMT----- 400

  Fly   481 DHPLTPTKFRQMTSTSSQTGQNGSGNGNGNGGYGGHGQSGGHHLYRQQSSCSANFSPLPQHAHQA 545
                             |:..||
 Worm   401 -----------------QSVSNG------------------------------------------ 406

  Fly   546 HASTTTSDLGMANPNVIKSTTTVNSVATASTLADSCCSGTIQIHQGMGAGAACQSSELLHHQQLH 610
                 .:.||.....:|.|..|...|:..:||                         |:.|:..|
 Worm   407 -----LTSLGSIPSTMISSNGTTTDVSQQATL-------------------------LILHRIYH 441

  Fly   611 HQQMHHQQQQQQQQQHHHHQRPTTSAAAAAAAAAAGGPSTSAAAAAAAAAAAAGTPPPPPPPAGV 675
            ..::
 Worm   442 ELKI------------------------------------------------------------- 445

  Fly   676 CDILPACQREGGPHCCSGRGNVRQRWHTCPELHKAMDGVTYIADQTRKEEESTRVKEDWKYVAMV 740
                                                  ||....:..|||::.   .:||:.|||
 Worm   446 --------------------------------------VTKRMIEGDKEEQAC---NNWKFAAMV 469

  Fly   741 LDRLFLWIFTIAVVVGTAGIILQAPTL 767
            :|||.|::|||.::|.|.||...||.|
 Worm   470 VDRLCLYVFTIFIIVSTIGIFWSAPYL 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	100/213 (47%)
		Neur_chan_memb	248..>359	CDD:280999	51/110 (46%)
		Neur_chan_memb	<683..760	CDD:280999	19/76 (25%)
acr-16	NP_505207.1	LIC	6..493	CDD:273305	206/737 (28%)
		Neur_chan_LBD	23..229	CDD:280998	100/213 (47%)
		Neur_chan_memb	236..490	CDD:280999	101/513 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910