DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nAChRalpha3 and lgc-27

DIOPT Version :10

Sequence 1:NP_525079.3 Gene:nAChRalpha3 / 31767 FlyBaseID:FBgn0015519 Length:795 Species:Drosophila melanogaster
Sequence 2:NP_740977.1 Gene:lgc-27 / 173802 WormBaseID:WBGene00022283 Length:428 Species:Caenorhabditis elegans


Alignment Length:330 Identity:80/330 - (24%)
Similarity:135/330 - (40%) Gaps:66/330 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 DAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQI---MTTNLWVEQSWYDYK 86
            ||.|:.|.  ||...::.|.|...:.|.|::   |...|.....|::   |..|.:::.||.|.:
 Worm    56 DADRMQDK--SNALMMLPPTVAAGETLEVQV---LDGSITEMWMNEVFKEMNINGFLKLSWKDRR 115

  Fly    87 LKWEPKEYGGVEMLHVPS-DHIWRPDI--------------VLYNNADGNFEVTLATKATLNYTG 136
            |:|.|:|: ..|:|.:.| ..:|.|||              |.|::...|:..        |.|.
 Worm   116 LRWNPEEW-KTEVLRLKSMGRLWSPDINSDKLQTGSQSTDFVNYHDIQSNYNG--------NVTA 171

  Fly   137 RVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEF 201
            |:|:|    .|:.|:||...:|.|.:.|.....|..|..:   :|.|.|..|.:.:     |:..
 Worm   172 RLEFR----MKAQCQIDYTEYPNDRKHCCFNLQSNLYKRY---VRFIMEHEGAHEM-----LNTK 224

  Fly   202 YTSVEWDILEVPAVRNEKFYTCCDE---------PYLDITFNITMRRKTLFYTVNLIIPCMGISF 257
            .|...|.|        :..||...:         ..|::...:..:..||  .|.|.:|.: ||.
 Worm   225 NTKTNWHI--------DPMYTWISKMNQENDNRAERLEVCVGVVRKSSTL--AVELTLPVL-ISA 278

  Fly   258 LTILVFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSL--VVPLLGKFVLFTMILDTFSIC 320
            |.:|:........:::.:.:..||...:.|..|||..|....  .:|.:..|..||:.:...|:.
 Worm   279 LILLLAPFFGKFNQQIYVKMFALLLQFLSFQFLAEKTPQLGFGDNIPKIYVFYAFTIGMTVLSLI 343

  Fly   321 VTVLV 325
            .||::
 Worm   344 ATVMI 348

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha3NP_525079.3 LGIC_ECD_nAChR_proto_alpha-like 25..243 CDD:349832 58/244 (24%)
Cys-loop 150..164 CDD:349832 5/13 (38%)
LGIC_TM_nAChR 242..>331 CDD:349866 22/86 (26%)
TM1 helix 242..266 CDD:349866 8/23 (35%)
TM2 helix 274..295 CDD:349866 6/20 (30%)
TM3 helix 306..328 CDD:349866 6/20 (30%)
Neur_chan_memb <683..760 CDD:460753
lgc-27NP_740977.1 LGIC_ECD 79..248 CDD:475126 48/200 (24%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.