DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha3 and HTR3C

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_570126.2	Gene:	HTR3C / 170572	HGNCID:	24003	Length:	447	Species:	Homo sapiens

Alignment Length:	325	Identity:	82/325 - (25%)
Similarity:	162/325 - (49%)	Gaps:	38/325 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 KLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVP 103
            |..||..|.:....|.|...||.::.|:.:.|::|:.||::..|.:..:.|.|||..|:..|.|.
Human    52 KAFRPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLTVL 116

  Fly   104 SDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKF 168
            ::::|.|||.:..:.|.: :......|.::..||:::..|....|.|.:|:.|||||:|.|...|
Human   117 AENLWLPDIFIVESMDVD-QTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQNCTFTF 180

  Fly   169 GSWTY--DGFQVDL-RHIDELNGTN--VVEVGVDLSEFYTSVEWDILEVPAVRNEKFYTCCDEPY 228
            .|:.|  |...:.: :.:.|:..|:  |::         |..||::|.:.....:  .:..:..|
Human   181 SSFLYTVDSMLLGMDKEVWEITDTSRKVIQ---------TQGEWELLGINKATPK--MSMGNNLY 234

  Fly   229 LDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSGEKVSLSISILLSLTVFFLLLAEI 293
            ..|.|.:.:||:...|.:||::|...:..:..|.||||::|..:....|::||...||.|::.::
Human   235 DQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVFLLMMNDL 299

  Fly   294 IPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLN----------IHFRSPQTHTMAPWVRTVFIN 348
            :|.:.  .||:..:         |::|::::|::          :|..:.|...|..|:.::.::
Human   300 LPASG--TPLISVY---------FALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLHSLLLH 353

Fly 349 348
Human 354 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	56/206 (27%)
		Neur_chan_memb	248..>359	CDD:280999	24/111 (22%)
		Neur_chan_memb	<683..760	CDD:280999
HTR3C	NP_570126.2	Neur_chan_LBD	43..445	CDD:332142	82/325 (25%)
HTR3C	NP_570126.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..405
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810