Protein Alignment nAChRalpha3 and HTR3C

DIOPT Version :10

• Sequence 1: NP_525079.3
• Gene: nAChRalpha3 / 31767
• FlyBaseID: FBgn0015519
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: NP_570126.2
• Gene: HTR3C / 170572
• HGNCID: 24003
• Length: 447
• Species: Homo sapiens
• Alignment Length: 325
• Identity: 82/325 - (25%)
• Similarity: 162/325 - (49%)
• Gaps: 38/325 - (11%)

  Fly    39 KLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVP 103
            |..||..|.:....|.|...||.::.|:.:.|::|:.||::..|.:..:.|.|||..|:..|.|.
Human    52 KAFRPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLTVL 116

  Fly   104 SDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKF 168
            ::::|.|||.:..:.|.: :......|.::..||:::..|....|.|.:|:.|||||:|.|...|
Human   117 AENLWLPDIFIVESMDVD-QTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQNCTFTF 180

  Fly   169 GSWTY--DGFQVDL-RHIDELNGTN--VVEVGVDLSEFYTSVEWDILEVPAVRNEKFYTCCDEPY 228
            .|:.|  |...:.: :.:.|:..|:  |::         |..||::|.:.....:  .:..:..|
Human   181 SSFLYTVDSMLLGMDKEVWEITDTSRKVIQ---------TQGEWELLGINKATPK--MSMGNNLY 234

  Fly   229 LDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSGEKVSLSISILLSLTVFFLLLAEI 293
            ..|.|.:.:||:...|.:||::|...:..:..|.||||::|..:....|::||...||.|::.::
Human   235 DQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVFLLMMNDL 299

  Fly   294 IPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLN----------IHFRSPQTHTMAPWVRTVFIN 348
            :|.:.  .||:..:         |::|::::|::          :|..:.|...|..|:.::.::
Human   300 LPASG--TPLISVY---------FALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLHSLLLH 353

  Fly   349  348
            Human   354  353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_525079.3	LGIC_ECD_nAChR_proto_alpha-like	25..243	CDD:349832	56/208 (27%)
		Cys-loop	150..164	CDD:349832	8/13 (62%)
		LGIC_TM_nAChR	242..>331	CDD:349866	23/98 (23%)
		TM1 helix	242..266	CDD:349866	7/23 (30%)
		TM2 helix	274..295	CDD:349866	6/20 (30%)
		TM3 helix	306..328	CDD:349866	3/31 (10%)
		Neur_chan_memb	<683..760	CDD:460753
HTR3C	NP_570126.2	LGIC_ECD_5-HT3C_E	31..246	CDD:349814	55/205 (27%)
		Cys-loop	162..176	CDD:349814	8/13 (62%)
		LGIC_TM_5-HT3	248..446	CDD:349865	26/117 (22%)
		TM1 helix	248..272	CDD:349865	7/23 (30%)
		TM2 helix	280..301	CDD:349865	6/20 (30%)
		TM3 helix	310..332	CDD:349865	3/30 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	380..405
		HA-stretch, determines single-channel conductance in 5-HT3 receptors. /evidence=ECO:0000250|UniProtKB:P46098	401..423
		TM4 helix	421..443	CDD:349865