DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha3 and CHRNE

DIOPT Version :10

Sequence 1:NP_525079.3 Gene:nAChRalpha3 / 31767 FlyBaseID:FBgn0015519 Length:795 Species:Drosophila melanogaster
Sequence 2:NP_000071.1 Gene:CHRNE / 1145 HGNCID:1966 Length:493 Species:Homo sapiens


Alignment Length:349 Identity:134/349 - (38%)
Similarity:211/349 - (60%) Gaps:2/349 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 IDMILVLSFISSSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIM 72
            :.::|:|..:.......:..|||..|.:||:...|||....|.:|:.:|:.|:.||.:|.|.:.:
Human     6 LGVLLLLGLLGRGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETL 70

  Fly    73 TTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGR 137
            ||::|:...|.||:|.:...::||:|.|.|||:.:|.|:|||.||.||.|.|.......:...|.
Human    71 TTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGS 135

  Fly   138 VEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFY 202
            |.|.|||||:|.|.::|.|||||.|.|.:.|.|.||:..:|:.....:.:|..:.::.:|...:.
Human   136 VTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYT 200

  Fly   203 TSVEWDILEVPAVRNEKFYTCCDEP-YLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLP 266
            .:.||.|...|.|.........|.| ..|:.:::.:|||.|||.:|:|:||:.||.|.:|.::||
Human   201 ENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLP 265

  Fly   267 SDS-GEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHF 330
            :.: |:|.::||::||:.|||..|:|:.||.|||.|||||:|::|.|::.|..:...|:|||:..
Human   266 AQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQ 330

  Fly   331 RSPQTHTMAPWVRTVFINQLPRFL 354
            |:|.||.|:|.:|.|.:..|||.|
Human   331 RTPTTHAMSPRLRHVLLELLPRLL 354

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha3NP_525079.3 LGIC_ECD_nAChR_proto_alpha-like 25..243 CDD:349832 78/218 (36%)
Cys-loop 150..164 CDD:349832 8/13 (62%)
LGIC_TM_nAChR 242..>331 CDD:349866 42/89 (47%)
TM1 helix 242..266 CDD:349866 11/23 (48%)
TM2 helix 274..295 CDD:349866 9/20 (45%)
TM3 helix 306..328 CDD:349866 7/21 (33%)
Neur_chan_memb <683..760 CDD:460753
CHRNENP_000071.1 LGIC_ECD_nAChR_E 49..239 CDD:349831 66/189 (35%)
Cys-loop 148..162 CDD:349831 8/13 (62%)
Neur_chan_memb 247..474 CDD:460753 50/108 (46%)
Blue background indicates that the domain is not in the aligned region.

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