Protein Alignment nAChRalpha3 and Chrng

DIOPT Version :9

• Sequence 1: NP_001285015.1
• Gene: nAChRalpha3 / 31767
• FlyBaseID: FBgn0015519
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: XP_006529141.1
• Gene: Chrng / 11449
• MGIID: 87895
• Length: 541
• Species: Mus musculus
• Alignment Length: 437
• Identity: 153/437 - (35%)
• Similarity: 248/437 - (56%)
• Gaps: 32/437 - (7%)

  Fly    17 ISSSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQS 81
            ::.:.:....:||..||:.||:..:||....:|.:.|.:||.|:.||.:|.:.:.:|||:|:|..
Mouse    39 VAGAQSRNQEERLLADLMRNYDPHLRPAERDSDVVNVSLKLTLTNLISLNEREEALTTNVWIEMQ 103

  Fly    82 WYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVEWRPPAIY 146
            |.||:|:|:||:|.|:.:|.|||..:|||||||.||.||.|||.|.....::..|.:.|.||||:
Mouse   104 WCDYRLRWDPKDYEGLWILRVPSTMVWRPDIVLENNVDGVFEVALYCNVLVSPDGCIYWLPPAIF 168

  Fly   147 KSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTSVEWDILE 211
            :|||.|.|.|||||.|.|.:.|.|.||...:::|: :.:.:|..:..:.:|...|..:.||.|..
Mouse   169 RSSCSISVTYFPFDWQNCSLVFQSQTYSTSEINLQ-LSQEDGQAIEWIFIDPEAFTENGEWAIRH 232

  Fly   212 VPAVRNEKFYTCCDEP-YLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDS-GEKVS 274
            .||..........:|. :..:.|.:.::||.|||.:|:|.||:.||.:.||:::||:.: |:|.:
Mouse   233 RPAKMLLDSVAPAEEAGHQKVVFYLLIQRKPLFYVINIIAPCVLISSVAILIYFLPAKAGGQKCT 297

  Fly   275 LSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQTHTMA 339
            ::.::||:.|||..|:|:.:|.||..|||:.|::.|.|::....:..:|:|||:..|||.||:||
Mouse   298 VATNVLLAQTVFLFLVAKKVPETSQAVPLISKYLTFLMVVTILIVVNSVVVLNVSLRSPHTHSMA 362

  Fly   340 PWVRTVFINQLPRFLVMR-RPLYPISEMIKSSR-RLMVRTCNG--LELRDQIPPLPP-------- 392
            ..||.||:..||:.|.|. |||.|.:  ::.:| ||...:.:|  :..|::.....|
Mouse   363 RGVRKVFLRLLPQLLRMHVRPLAPAA--VQDARFRLQNGSSSGWPIMAREEGDLCLPRSELLFRQ 425

  Fly   393 -------PVALSRMHHSPKT--------TSRSTSPHLQHRVQTYNLM 424
                   ...|.::.:.|:.        :.:..||.:|..|...|||
Mouse   426 RQRNGLVQAVLEKLENGPEVRQSQEFCGSLKQASPAIQACVDACNLM 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	83/215 (39%)
		Neur_chan_memb	248..>359	CDD:280999	46/112 (41%)
		Neur_chan_memb	<683..760	CDD:280999
Chrng	XP_006529141.1	LGIC_ECD_nAChR_G	71..263	CDD:349830	75/192 (39%)
		Neur_chan_memb	270..515	CDD:367256	65/205 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810