Protein Alignment nAChRalpha3 and Chrnd

DIOPT Version :10

• Sequence 1: NP_525079.3
• Gene: nAChRalpha3 / 31767
• FlyBaseID: FBgn0015519
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: NP_067611.2
• Gene: Chrnd / 11447
• MGIID: 87893
• Length: 520
• Species: Mus musculus
• Alignment Length: 483
• Identity: 165/483 - (34%)
• Similarity: 263/483 - (54%)
• Gaps: 38/483 - (7%)

  Fly     6 VTIDMI--LVLSFISSSTANPDAKRLYDDLLS--NYNKLVRPVVNVTDALTVRIKLKLSQLIDVN 66
            :|:.::  ||:..:..|....:.:||...|.:  .|:|.:|||....|.:.|.:.|.||.||.:.
Mouse     6 LTLGLLAALVVCALPGSWGLNEEQRLIQHLFNEKGYDKDLRPVARKEDKVDVALSLTLSNLISLK 70

  Fly    67 LKNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKAT 131
            ...:.:|||:|::.:|.|.:|:|:..::|.:.:|.:|.|.:|.|:|||.||.||:|:::.|....
Mouse    71 EVEETLTTNVWIDHAWVDSRLQWDANDFGNITVLRLPPDMVWLPEIVLENNNDGSFQISYACNVL 135

  Fly   132 LNYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQV--DLRHIDELNGTNVVE- 193
            :..:|.|.|.||||::|||.|.|.|||||.|.|.:||.|..|...::  .|:..:|.|.:..:|
Mouse   136 VYDSGYVTWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQEEENNRSYPIEW 200

  Fly   194 VGVDLSEFYTSVEWDILEVPAVRNEKFYTCCDEP-YLDITFNITMRRKTLFYTVNLIIPCMGISF 257
            :.:|...|..:.||:|:...|..|.......|.. :.|:||.:.:|||.|||.:|:::||:.|||
Mouse   201 IIIDPEGFTENGEWEIVHRAAKLNVDPSVPMDSTNHQDVTFYLIIRRKPLFYIINILVPCVLISF 265

  Fly   258 LTILVFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVT 322
            :..||||||.|.|||.|::||:||:.:||.||:::.:|.||:.:||:|||:||.|:|.|..:.:.
Mouse   266 MINLVFYLPGDCGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLVGKFLLFGMVLVTMVVVIC 330

  Fly   323 VLVLNIHFRSPQTHTMAPWVRTVFINQLPRFLVMRRPL-------------YPISEMIKSSRRLM 374
            |:|||||||:|.||.::..|:..|:..||:.|.|.||.             ..:..:.|:.....
Mouse   331 VIVLNIHFRTPSTHVLSEGVKKFFLETLPKLLHMSRPAEEDPGPRALIRRSSSLGYICKAEEYFS 395

  Fly   375 VRTCNGLELRDQIPPLPPPVALSRMHHSPK--TTSRSTSPHLQHRVQTYNLMDECGMGMGGGAST 437
            :::.:.|....|          |..|...:  ||:| ..|....:|| ..|.:|....: .||:.
Mouse   396 LKSRSDLMFEKQ----------SERHGLARRLTTAR-RPPASSEQVQ-QELFNEMKPAV-DGANF 447

  Fly   438 ITGHL--SSLYPPTMSTANQQTSTTSSL 463
            |..|:  .:.|.......||...|...|
Mouse   448 IVNHMRDQNSYNEEKDNWNQVARTVDRL 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_525079.3	LGIC_ECD_nAChR_proto_alpha-like	25..243	CDD:349832	79/223 (35%)
		Cys-loop	150..164	CDD:349832	9/13 (69%)
		LGIC_TM_nAChR	242..>331	CDD:349866	47/88 (53%)
		TM1 helix	242..266	CDD:349866	13/23 (57%)
		TM2 helix	274..295	CDD:349866	9/20 (45%)
		TM3 helix	306..328	CDD:349866	10/21 (48%)
		Neur_chan_memb	<683..760	CDD:460753
Chrnd	NP_067611.2	LGIC_ECD	29..249	CDD:475126	78/219 (36%)
		Neur_chan_memb	256..492	CDD:460753	78/233 (33%)