DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha3 and Chrnd

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_067611.2	Gene:	Chrnd / 11447	MGIID:	87893	Length:	520	Species:	Mus musculus

Alignment Length:	483	Identity:	165/483 - (34%)
Similarity:	263/483 - (54%)	Gaps:	38/483 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VTIDMI--LVLSFISSSTANPDAKRLYDDLLS--NYNKLVRPVVNVTDALTVRIKLKLSQLIDVN 66
            :|:.::  ||:..:..|....:.:||...|.:  .|:|.:|||....|.:.|.:.|.||.||.:.
Mouse     6 LTLGLLAALVVCALPGSWGLNEEQRLIQHLFNEKGYDKDLRPVARKEDKVDVALSLTLSNLISLK 70

  Fly    67 LKNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKAT 131
            ...:.:|||:|::.:|.|.:|:|:..::|.:.:|.:|.|.:|.|:|||.||.||:|:::.|....
Mouse    71 EVEETLTTNVWIDHAWVDSRLQWDANDFGNITVLRLPPDMVWLPEIVLENNNDGSFQISYACNVL 135

  Fly   132 LNYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQV--DLRHIDELNGTNVVE- 193
            :..:|.|.|.||||::|||.|.|.|||||.|.|.:||.|..|...::  .|:..:|.|.:..:|
Mouse   136 VYDSGYVTWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQEEENNRSYPIEW 200

  Fly   194 VGVDLSEFYTSVEWDILEVPAVRNEKFYTCCDEP-YLDITFNITMRRKTLFYTVNLIIPCMGISF 257
            :.:|...|..:.||:|:...|..|.......|.. :.|:||.:.:|||.|||.:|:::||:.|||
Mouse   201 IIIDPEGFTENGEWEIVHRAAKLNVDPSVPMDSTNHQDVTFYLIIRRKPLFYIINILVPCVLISF 265

  Fly   258 LTILVFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVT 322
            :..||||||.|.|||.|::||:||:.:||.||:::.:|.||:.:||:|||:||.|:|.|..:.:.
Mouse   266 MINLVFYLPGDCGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLVGKFLLFGMVLVTMVVVIC 330

  Fly   323 VLVLNIHFRSPQTHTMAPWVRTVFINQLPRFLVMRRPL-------------YPISEMIKSSRRLM 374
            |:|||||||:|.||.::..|:..|:..||:.|.|.||.             ..:..:.|:.....
Mouse   331 VIVLNIHFRTPSTHVLSEGVKKFFLETLPKLLHMSRPAEEDPGPRALIRRSSSLGYICKAEEYFS 395

  Fly   375 VRTCNGLELRDQIPPLPPPVALSRMHHSPK--TTSRSTSPHLQHRVQTYNLMDECGMGMGGGAST 437
            :::.:.|....|          |..|...:  ||:| ..|....:|| ..|.:|....: .||:.
Mouse   396 LKSRSDLMFEKQ----------SERHGLARRLTTAR-RPPASSEQVQ-QELFNEMKPAV-DGANF 447

  Fly   438 ITGHL--SSLYPPTMSTANQQTSTTSSL 463
            |..|:  .:.|.......||...|...|
Mouse   448 IVNHMRDQNSYNEEKDNWNQVARTVDRL 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	78/220 (35%)
		Neur_chan_memb	248..>359	CDD:280999	54/110 (49%)
		Neur_chan_memb	<683..760	CDD:280999
Chrnd	NP_067611.2	LIC	1..479	CDD:273305	165/483 (34%)
		Neur_chan_LBD	28..249	CDD:280998	78/220 (35%)
		Neur_chan_memb	256..492	CDD:280999	78/233 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810