Protein Alignment nAChRalpha3 and Chrnb1

DIOPT Version :9

• Sequence 1: NP_001285015.1
• Gene: nAChRalpha3 / 31767
• FlyBaseID: FBgn0015519
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: NP_033731.3
• Gene: Chrnb1 / 11443
• MGIID: 87890
• Length: 501
• Species: Mus musculus
• Alignment Length: 769
• Identity: 208/769 - (27%)
• Similarity: 304/769 - (39%)
• Gaps: 298/769 - (38%)

  Fly    10 MILVLSFISSSTANPDAK------RLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLK 68
            ::|:|..:.:..| |.|:      :|...|.|||:..|||...|.|.:.|.|.|.|:|||.:|.|
Mouse     6 LLLLLGVLGTPLA-PGARGSEAEGQLIKKLFSNYDSSVRPAREVGDRVGVSIGLTLAQLISLNEK 69

  Fly    69 NQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLN 133
            ::.|:|.::::..|.||:|.|:|.|:.|::.|.:.::.:|.||:||.||.||||:|.|.....::
Mouse    70 DEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDINVVVS 134

  Fly   134 YTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDL 198
            :.|.|.|:||.:|:|||.|.|.|||||.|.|.|.|.|::||..:|.|:...:..|....||.:..
Mouse   135 FEGSVRWQPPGLYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLKTGLDPEGEERQEVYIHE 199

  Fly   199 SEFYTSVEWDILEVPA--------VRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGI 255
            ..|..:.:|:|:..|:        .|..|     :..:.::.|.:.:|||.|||.||:|.||:.|
Mouse   200 GTFIENGQWEIIHKPSRLIQLPGDQRGGK-----EGHHEEVIFYLIIRRKPLFYLVNVIAPCILI 259

  Fly   256 SFLTILVFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSIC 320
            :.|.|.|||||.|:|||:.|||..||:||||.||||:.:|.|||.||::.|:::|||:|.|||:.
Mouse   260 TLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLAVPIIIKYLMFTMVLVTFSVI 324

  Fly   321 VTVLVLNIHFRSPQTHTMAPWVRTVFINQLPRFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRD 385
            ::|:|||:|.|||.||.|..|||.:||::||.:|.::||        |..             ||
Mouse   325 LSVVVLNLHHRSPHTHQMPFWVRQIFIHKLPPYLGLKRP--------KPE-------------RD 368

  Fly   386 QIPPLPPPVALSRMHHSPKTTSRSTSPHLQHRVQTYNLMDECGMGMGGGASTITGHLSSLYPPTM 450
            |:|                      .||
Mouse   369 QLP----------------------EPH------------------------------------- 374

  Fly   451 STANQQTSTTSSLIDAQYHNQYQQTGGSLLDHPLTPTKFRQMTSTSSQTGQNGSGNGNGNGGYGG 515
                                           |.|:|.                ||.|.|...|
Mouse   375 -------------------------------HSLSPR----------------SGWGRGTDEY-- 390

  Fly   516 HGQSGGHHLYRQQSSCSANFSPLPQHAHQAHASTTTSDLGMANPNVIKSTTTVNSVATASTLADS 580
                               |...|           .||......|
Mouse   391 -------------------FIRKP-----------PSDFLFPKLN-------------------- 405

  Fly   581 CCSGTIQIHQGMGAGAACQSSELLHHQQLHHQQMHHQQQQQQQQQHHHHQRPTTSAAAAAAAAAA 645
                                                              |....::|.......
Mouse   406 --------------------------------------------------RFQPESSAPDLRRFI 420

  Fly   646 GGPSTSAAAAAAAAAAAAGTPPPPPPPAGVCDILPACQREGGPHCCSGRGNVRQRWHTCPELHKA 710
            .||:           .|.|.|                                      .||.:.
Mouse   421 DGPT-----------RAVGLP--------------------------------------QELREV 436

  Fly   711 MDGVTYIADQTRKEEESTRVKEDWKYVAMVLDRLFLWIFTIAVVVGTAGIILQA 764
            :..::|:|.|.:::|:...:||||::||||:||||||.|.:...|||..|.|.|
Mouse   437 ISSISYMARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIVFTSVGTLVIFLDA 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	81/228 (36%)
		Neur_chan_memb	248..>359	CDD:280999	61/110 (55%)
		Neur_chan_memb	<683..760	CDD:280999	24/76 (32%)
Chrnb1	NP_033731.3	LIC	24..488	CDD:273305	201/746 (27%)
		Neur_chan_LBD	27..245	CDD:280998	80/222 (36%)
		Neur_chan_memb	252..487	CDD:280999	114/512 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	362..382		12/146 (8%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810