DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha3 and CHRND

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_000742.1	Gene:	CHRND / 1144	HGNCID:	1965	Length:	517	Species:	Homo sapiens

Alignment Length:	464	Identity:	171/464 - (36%)
Similarity:	256/464 - (55%)	Gaps:	53/464 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VTIDMILVLSFISSSTANPDAKRLYDDLL--SNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLK 68
            :|:.::..|:...|...| :.:||...|.  ..|||.:|||.:..:::.|.:.|.||.||.:...
Human     6 LTLGLLAALAVCGSWGLN-EEERLIRHLFQEKGYNKELRPVAHKEESVDVALALTLSNLISLKEV 69

  Fly    69 NQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLN 133
            .:.:|||:|:|..|.|.:|||..:|:|.:.:|.:|.|.:|.|:|||.||.||:|:::.:....:.
Human    70 EETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEIVLENNNDGSFQISYSCNVLVY 134

  Fly   134 YTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQV--DLRHIDELNGTNVVE-VG 195
            :.|.|.|.||||::|||.|.|.|||||.|.|.:||.|..|...::  .|:...:.|.|..|| :.
Human   135 HYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSLKQDAKENRTYPVEWII 199

  Fly   196 VDLSEFYTSVEWDILEVPAVRNEKFYTCCDEP-YLDITFNITMRRKTLFYTVNLIIPCMGISFLT 259
            :|...|..:.||:|:..||..|.......|.| ..||||.:.:|||.|||.:|:::||:.|||:.
Human   200 IDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSRQDITFYLIIRRKPLFYIINILVPCVLISFMV 264

  Fly   260 ILVFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVL 324
            .||||||:|||||.|::||:||:.:||.||:::.:|.||:.:||:|||:||.|:|.|..:.:.|:
Human   265 NLVFYLPADSGEKTSVAISVLLAQSVFLLLISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVI 329

  Fly   325 VLNIHFRSPQTHTMAPWVRTVFINQLPRFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRDQIPP 389
            |||||||:|.||.::..|:.:|:..||..|.|.||..                 :|
Human   330 VLNIHFRTPSTHVLSEGVKKLFLETLPELLHMSRPAE-----------------DG--------- 368

  Fly   390 LPPPVALSRMHHSPKTTSRSTSPHLQHRVQTY-------NLMDECGMGMGGGASTITGHLSSLYP 447
             |.|.||.|         ||:|.....:.:.|       :||.|......|.|..:|   ::..|
Human   369 -PSPGALVR---------RSSSLGYISKAEEYFLLKSRSDLMFEKQSERHGLARRLT---TARRP 420

  Fly   448 PTMSTANQQ 456
            |..|...||
Human   421 PASSEQAQQ 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	84/220 (38%)
		Neur_chan_memb	248..>359	CDD:280999	55/110 (50%)
		Neur_chan_memb	<683..760	CDD:280999
CHRND	NP_000742.1	Neur_chan_LBD	25..246	CDD:308532	84/220 (38%)
CHRND	NP_000742.1	Neur_chan_memb	253..489	CDD:308533	78/216 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810