DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha3 and Chrna1

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_031415.2	Gene:	Chrna1 / 11435	MGIID:	87885	Length:	457	Species:	Mus musculus

Alignment Length:	400	Identity:	189/400 - (47%)
Similarity:	256/400 - (64%)	Gaps:	26/400 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 MILVLSFISSS--TANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIM 72
            ::|:|...|:.  ..:....||...|..:|:.:||||.:..:.:.|.:.|:|.|||:|:..|||:
Mouse     6 VLLLLGLCSAGLVLGSEHETRLVAKLFEDYSSVVRPVEDHREIVQVTVGLQLIQLINVDEVNQIV 70

  Fly    73 TTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGR 137
            |||:.::|.|.||.|||.|.:||||:.:|:||:.|||||:||||||||:|.:...||..|:|||.
Mouse    71 TTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDVVLYNNADGDFAIVKFTKVLLDYTGH 135

  Fly   138 VEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFY 202
            :.|.||||:||.|||.|.:||||||.|.||.|:|||||..|.:         |......|||.|.
Mouse   136 ITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAI---------NPESDQPDLSNFM 191

  Fly   203 TSVEWDILEVPAVRNEKFYTCC-DEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLP 266
            .|.||.|.|....::..||:|| ..||||||::..|:|..|::.||:||||:..||||.||||||
Mouse   192 ESGEWVIKEARGWKHWVFYSCCPTTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTSLVFYLP 256

  Fly   267 SDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFR 331
            :|||||::||||:|||||||.|::.|:||.||..|||:||::||||:....||.:||:|:|.|.|
Mouse   257 TDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHR 321

  Fly   332 SPQTHTMAPWVRTVFINQLPR---FLVMRRPLYPISEMIKSSRRLMVRTCNGLELRDQIPPLPPP 393
            ||.||.|..|||.|||:.:|.   |..|:||     ...|..:|:.....:..::..:  |.|||
Mouse   322 SPSTHIMPEWVRKVFIDTIPNIMFFSTMKRP-----SRDKQEKRIFTEDIDISDISGK--PGPPP 379

  Fly   394 VALSRMHHSP 403
            :..    |||
Mouse   380 MGF----HSP 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	105/215 (49%)
		Neur_chan_memb	248..>359	CDD:280999	67/113 (59%)
		Neur_chan_memb	<683..760	CDD:280999
Chrna1	NP_031415.2	Neur_chan_LBD	24..231	CDD:308532	105/215 (49%)
Chrna1	NP_031415.2	Neur_chan_memb	238..446	CDD:308533	77/158 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920