DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha3 and Chrna1

DIOPT Version :10

Sequence 1:NP_525079.3 Gene:nAChRalpha3 / 31767 FlyBaseID:FBgn0015519 Length:795 Species:Drosophila melanogaster
Sequence 2:NP_031415.2 Gene:Chrna1 / 11435 MGIID:87885 Length:457 Species:Mus musculus


Alignment Length:400 Identity:189/400 - (47%)
Similarity:256/400 - (64%) Gaps:26/400 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 MILVLSFISSS--TANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIM 72
            ::|:|...|:.  ..:....||...|..:|:.:||||.:..:.:.|.:.|:|.|||:|:..|||:
Mouse     6 VLLLLGLCSAGLVLGSEHETRLVAKLFEDYSSVVRPVEDHREIVQVTVGLQLIQLINVDEVNQIV 70

  Fly    73 TTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGR 137
            |||:.::|.|.||.|||.|.:||||:.:|:||:.|||||:||||||||:|.:...||..|:|||.
Mouse    71 TTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDVVLYNNADGDFAIVKFTKVLLDYTGH 135

  Fly   138 VEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFY 202
            :.|.||||:||.|||.|.:||||||.|.||.|:|||||..|.:         |......|||.|.
Mouse   136 ITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAI---------NPESDQPDLSNFM 191

  Fly   203 TSVEWDILEVPAVRNEKFYTCC-DEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLP 266
            .|.||.|.|....::..||:|| ..||||||::..|:|..|::.||:||||:..||||.||||||
Mouse   192 ESGEWVIKEARGWKHWVFYSCCPTTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTSLVFYLP 256

  Fly   267 SDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFR 331
            :|||||::||||:|||||||.|::.|:||.||..|||:||::||||:....||.:||:|:|.|.|
Mouse   257 TDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHR 321

  Fly   332 SPQTHTMAPWVRTVFINQLPR---FLVMRRPLYPISEMIKSSRRLMVRTCNGLELRDQIPPLPPP 393
            ||.||.|..|||.|||:.:|.   |..|:||     ...|..:|:.....:..::..:  |.|||
Mouse   322 SPSTHIMPEWVRKVFIDTIPNIMFFSTMKRP-----SRDKQEKRIFTEDIDISDISGK--PGPPP 379

  Fly   394 VALSRMHHSP 403
            :..    |||
Mouse   380 MGF----HSP 385

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha3NP_525079.3 LGIC_ECD_nAChR_proto_alpha-like 25..243 CDD:349832 105/218 (48%)
Cys-loop 150..164 CDD:349832 10/13 (77%)
LGIC_TM_nAChR 242..>331 CDD:349866 55/88 (63%)
TM1 helix 242..266 CDD:349866 15/23 (65%)
TM2 helix 274..295 CDD:349866 13/20 (65%)
TM3 helix 306..328 CDD:349866 10/21 (48%)
Neur_chan_memb <683..760 CDD:460753
Chrna1NP_031415.2 LIC 21..447 CDD:455710 185/384 (48%)
LGIC_ECD_nAChR_A1 22..231 CDD:349815 105/217 (48%)
Cys-loop 148..162 CDD:349815 10/13 (77%)
Blue background indicates that the domain is not in the aligned region.

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