DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nAChRalpha3 and CHRNB4

DIOPT Version :9

Sequence 1:NP_001285015.1 Gene:nAChRalpha3 / 31767 FlyBaseID:FBgn0015519 Length:795 Species:Drosophila melanogaster
Sequence 2:NP_000741.1 Gene:CHRNB4 / 1143 HGNCID:1964 Length:498 Species:Homo sapiens


Alignment Length:770 Identity:235/770 - (30%)
Similarity:332/770 - (43%) Gaps:302/770 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 LVLSFI-------SSSTANPDAKRLYDDLL--SNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNL 67
            |||.|:       :...||.:.| |.||||  :.||.|:||..:.:..::::::|.|:|||.||.
Human     7 LVLFFLVALCGRGNCRVANAEEK-LMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNE 70

  Fly    68 KNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATL 132
            :.||||||:|::|.|.||:|.|....|.||.:|.:|:..||.|||||||||||.:||::.|...:
Human    71 REQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYTNLIV 135

  Fly   133 NYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVD 197
            ...|.|.|.|||||||:|:|:|:|||||:|.|.:||.|||||..::|:         .::.....
Human   136 RSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDM---------VLMTPTAS 191

  Fly   198 LSEFYTSVEWDILEVPAVR--NEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTI 260
            :.:|..|.||||:.:|..|  |.:     |..|:|:|::..::||.||||:||||||:..:.|.|
Human   192 MDDFTPSGEWDIVALPGRRTVNPQ-----DPSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLLAI 251

  Fly   261 LVFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLV 325
            ||||||||.|||::|.||:||:||.|.||:::|:|||||.|||:||:::|||:|.||||..:|.|
Human   252 LVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCV 316

  Fly   326 LNIHFRSPQTHTMAPWVRTVFINQLPRFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRDQIPPL 390
            ||:|.|||.||||||||:..|:::||.||.|:||                               
Human   317 LNVHHRSPSTHTMAPWVKRCFLHKLPTFLFMKRP------------------------------- 350

  Fly   391 PPPVALSRMHHSPKTTSRSTSPHLQHRVQTYNLMDECGMGMGGGASTITGHLSSLYPPTMSTANQ 455
                            ...:||                              :..:||:.|...:
Human   351 ----------------GPDSSP------------------------------ARAFPPSKSCVTK 369

  Fly   456 QTSTTSSLIDAQYHNQYQQTGGSLLDHPLTPTKFRQMTSTSSQTGQNGSGNGNGNGGYGGHGQSG 520
            ..:|.                                ||||       ..|..||..|       
Human   370 PEATA--------------------------------TSTS-------PSNFYGNSMY------- 388

  Fly   521 GHHLYRQQSSCSANFSPLPQHAHQAHASTTTSDLGMANPNVIKSTTTVNSVATASTLADSCCSGT 585
                                               ..||                          
Human   389 -----------------------------------FVNP-------------------------- 392

  Fly   586 IQIHQGMGAGAACQSSELLHHQQLHHQQMHHQQQQQQQQQHHHHQRPTTSAAAAAAAAAAGGPST 650
                                                                             
Human   393 ----------------------------------------------------------------- 392

  Fly   651 SAAAAAAAAAAAAGTPPPPPPPAGVCDILPACQREGGPHCCSGRGNVRQRWHTCPELHKAMDGVT 715
                |:||:.:.||:.|...|            |:   ......|..||      ::.:|::||:
Human   393 ----ASAASKSPAGSTPVAIP------------RD---FWLRSSGRFRQ------DVQEALEGVS 432

  Fly   716 YIADQTRKEEESTRVKEDWKYVAMVLDRLFLWIFTIAVVVGTAGIILQAPTLYDT 770
            :||...:.::|...|.|||||||||:||||||:|....|:||.|:.|  |.|:.|
Human   433 FIAQHMKNDDEDQSVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFL--PPLFQT 485

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha3NP_001285015.1 Neur_chan_LBD 26..241 CDD:280998 94/218 (43%)
Neur_chan_memb 248..>359 CDD:280999 69/110 (63%)
Neur_chan_memb <683..760 CDD:280999 30/76 (39%)
CHRNB4NP_000741.1 Neur_chan_LBD 5..480 CDD:332142 232/763 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 357..377 5/51 (10%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3645
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D188416at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm8639
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

Return to query results.
Submit another query.