DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha3 and CHRNB3

DIOPT Version :10

Sequence 1:NP_525079.3 Gene:nAChRalpha3 / 31767 FlyBaseID:FBgn0015519 Length:795 Species:Drosophila melanogaster
Sequence 2:NP_000740.1 Gene:CHRNB3 / 1142 HGNCID:1963 Length:458 Species:Homo sapiens


Alignment Length:356 Identity:179/356 - (50%)
Similarity:240/356 - (67%) Gaps:21/356 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 MILVLSFISSSTA-------NPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNL 67
            :::||...||:|.       |.||  |...|...|.|.||||::..|.:.|...||:|||:||:.
Human     8 VLIVLGIPSSATTGFNSIAENEDA--LLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDVDE 70

  Fly    68 KNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATL 132
            |||:||||:|::|.|.|:||:|.|.:|||:..:.|||:.:|.|||||:.||||.||.:|.||..:
Human    71 KNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIV 135

  Fly   133 NYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVD 197
            ...|.|.|.|||.|||||.:||.:||||.|.|.||||||||||..|||..|:|         .||
Human   136 KSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINE---------NVD 191

  Fly   198 LSEFYTSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILV 262
            ..:|:.:.||:||....::..:.......|:  ||::..:||..||||:.|||||:|:||||:||
Human   192 RKDFFDNGEWEILNAKGMKGNRRDGVYSYPF--ITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLV 254

  Fly   263 FYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLN 327
            ||||||.|||:|||.|:|:|||||.|::.||||.:|.|:||:|:::||.||..|.||.|||.|:|
Human   255 FYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVIN 319

  Fly   328 IHFRSPQT-HTMAPWVRTVFINQLPRFLVMR 357
            :|.||..| |.|||||:.:|:.:||:.|.|:
Human   320 VHHRSSSTYHPMAPWVKRLFLQKLPKLLCMK 350

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha3NP_525079.3 LGIC_ECD_nAChR_proto_alpha-like 25..243 CDD:349832 101/217 (47%)
Cys-loop 150..164 CDD:349832 8/13 (62%)
LGIC_TM_nAChR 242..>331 CDD:349866 58/88 (66%)
TM1 helix 242..266 CDD:349866 18/23 (78%)
TM2 helix 274..295 CDD:349866 13/20 (65%)
TM3 helix 306..328 CDD:349866 11/21 (52%)
Neur_chan_memb <683..760 CDD:460753
CHRNB3NP_000740.1 LIC 23..449 CDD:455710 174/341 (51%)
Blue background indicates that the domain is not in the aligned region.

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