DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha3 and CHRNB3

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_000740.1	Gene:	CHRNB3 / 1142	HGNCID:	1963	Length:	458	Species:	Homo sapiens

Alignment Length:	356	Identity:	179/356 - (50%)
Similarity:	240/356 - (67%)	Gaps:	21/356 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 MILVLSFISSSTA-------NPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNL 67
            :::||...||:|.       |.||  |...|...|.|.||||::..|.:.|...||:|||:||:.
Human     8 VLIVLGIPSSATTGFNSIAENEDA--LLRHLFQGYQKWVRPVLHSNDTIKVYFGLKISQLVDVDE 70

  Fly    68 KNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATL 132
            |||:||||:|::|.|.|:||:|.|.:|||:..:.|||:.:|.|||||:.||||.||.:|.||..:
Human    71 KNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFENADGRFEGSLMTKVIV 135

  Fly   133 NYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVD 197
            ...|.|.|.|||.|||||.:||.:||||.|.|.||||||||||..|||..|:|         .||
Human   136 KSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINE---------NVD 191

  Fly   198 LSEFYTSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILV 262
            ..:|:.:.||:||....::..:.......|:  ||::..:||..||||:.|||||:|:||||:||
Human   192 RKDFFDNGEWEILNAKGMKGNRRDGVYSYPF--ITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLV 254

  Fly   263 FYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLN 327
            ||||||.|||:|||.|:|:|||||.|::.||||.:|.|:||:|:::||.||..|.||.|||.|:|
Human   255 FYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVIN 319

  Fly   328 IHFRSPQT-HTMAPWVRTVFINQLPRFLVMR 357
            :|.||..| |.|||||:.:|:.:||:.|.|:
Human   320 VHHRSSSTYHPMAPWVKRLFLQKLPKLLCMK 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	100/214 (47%)
		Neur_chan_memb	248..>359	CDD:280999	68/111 (61%)
		Neur_chan_memb	<683..760	CDD:280999
CHRNB3	NP_000740.1	Neur_chan_LBD	23..449	CDD:332142	174/341 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	251	1.000	Domainoid score	I2107
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820