DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha3 and CHRNB2

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_000739.1	Gene:	CHRNB2 / 1141	HGNCID:	1962	Length:	502	Species:	Homo sapiens

Alignment Length:	760	Identity:	244/760 - (32%)
Similarity:	331/760 - (43%)	Gaps:	297/760 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LVLSF----ISSSTANPDA-KRLYDDLL--SNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKN 69
            |:|.|    :.|.....|. :||.:.||  |.||||:||..|.::.:||::.:.|:|||.|:.:.
Human    10 LLLGFGLLRLCSGVWGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHERE 74

  Fly    70 QIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNY 134
            ||||||:|:.|.|.||:|.|:|:|:..::.:.:||.|||.||:||||||||.:||:..:.|.::|
Human    75 QIMTTNVWLTQEWEDYRLTWKPEEFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSY 139

  Fly   135 TGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLS 199
            .|.:.|.|||||||:|:|:|::||||:|.|.|||.|||||..::||....|:         ..|.
Human   140 DGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSEV---------ASLD 195

  Fly   200 EFYTSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFY 264
            :|..|.||||:.:|..|||   ...|..|:|||::..:|||.||||:||||||:.|:.|.|||||
Human   196 DFTPSGEWDIVALPGRRNE---NPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFY 257

  Fly   265 LPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIH 329
            ||||.|||::|.||:||:||||.||:::|:|||||.|||:||:::|||:|.||||..:|.|||:|
Human   258 LPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVH 322

  Fly   330 FRSPQTHTMAPWVRTVFINQLPRFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRDQIPPLPPPV 394
            .|||.||||||||:.||:.:||..|.|::|
Human   323 HRSPTTHTMAPWVKVVFLEKLPALLFMQQP----------------------------------- 352

  Fly   395 ALSRMHHSPKTTSRSTSPHLQHRVQTYNLMDECGMGMGGGASTITGHLSSLYPPTMSTANQQTST 459
                .||..:...|     |:.|
Human   353 ----RHHCARQRLR-----LRRR------------------------------------------ 366

  Fly   460 TSSLIDAQYHNQYQQTG-GSLLDHPLTPTKFRQMTSTSSQTGQNGSGNGNGNGGYGGHGQSGGHH 523
                       |.::.| |:|.        ||:...
Human   367 -----------QREREGAGALF--------FREAPG----------------------------- 383

  Fly   524 LYRQQSSCSANFSPLPQHAHQAHASTTTSDLGMANPNVIKSTTTVNSVATASTLADSCCSGTIQI 588
                                                                  ||||   |..:
Human   384 ------------------------------------------------------ADSC---TCFV 391

  Fly   589 HQGMGAGAACQSSELLHHQQLHHQQMHHQQQQQQQQQHHHHQRPTTSAAAAAAAAAAGGPSTSAA 653
            ::
Human   392 NR--------------------------------------------------------------- 393

  Fly   654 AAAAAAAAAAGTPPPPPPPAGVCDILPACQREGGPHCCSGRGNVRQRWHTCPELHKAMDGVTYIA 718
            |:....|.|.|..|.|....|         |.|.|..|.              |.:|:|||.:||
Human   394 ASVQGLAGAFGAEPAPVAGPG---------RSGEPCGCG--------------LREAVDGVRFIA 435

  Fly   719 DQTRKEEESTRVKEDWKYVAMVLDRLFLWIFTIAVVVGTAGIILQ 763
            |..|.|::...|.|||||||||:||||||||....|.||.|:.||
Human   436 DHMRSEDDDQSVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQ 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	100/217 (46%)
		Neur_chan_memb	248..>359	CDD:280999	71/110 (65%)
		Neur_chan_memb	<683..760	CDD:280999	35/76 (46%)
CHRNB2	NP_000739.1	LIC	29..479	CDD:273305	237/738 (32%)
		LGIC_ECD_nAChR_B2	31..234	CDD:349826	100/214 (47%)
		Cys-loop	155..169	CDD:349826	8/13 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8639
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820