Protein Alignment nAChRalpha3 and CHRNB1

DIOPT Version :9

• Sequence 1: NP_001285015.1
• Gene: nAChRalpha3 / 31767
• FlyBaseID: FBgn0015519
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: NP_000738.2
• Gene: CHRNB1 / 1140
• HGNCID: 1961
• Length: 501
• Species: Homo sapiens
• Alignment Length: 744
• Identity: 204/744 - (27%)
• Similarity: 290/744 - (38%)
• Gaps: 289/744 - (38%)

  Fly    28 RLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLKWEPK 92
            ||.:.|.|.|:..|||...|.|.:.|.:.|.|:|||.:|.|::.|:|.::::..|.||:|.|:|.
Human    29 RLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPA 93

  Fly    93 EYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVEWRPPAIYKSSCEIDVEYF 157
            |:.|::.|.:.::.:|.||:||.||.||||:|.|.....::..|.|.|:||.||:|||.|.|.||
Human    94 EHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYF 158

  Fly   158 PFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTSVEWDILEVPAVRNEKFYT 222
            |||.|.|.|.|.|::||..:|.|:.....:|....|:.:....|..:.:|:|:..|:    :...
Human   159 PFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPS----RLIQ 219

  Fly   223 CCDEP-------YLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSGEKVSLSISIL 280
            ...:|       ..::.|.:.:|||.|||.||:|.||:.|:.|.|.|||||.|:|||:.|||..|
Human   220 PPGDPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFAL 284

  Fly   281 LSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQTHTMAPWVRTV 345
            |:||||.||||:.:|.|||.||::.|:::|||:|.|||:.::|:|||:|.|||.||.|..|||.:
Human   285 LTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQI 349

  Fly   346 FINQLPRFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRDQIPPLPPPVALSRMHHSPKTTSRST 410
            ||::||.:|.::||        |..|.||              |.||
Human   350 FIHKLPLYLRLKRP--------KPERDLM--------------PEPP------------------ 374

  Fly   411 SPHLQHRVQTYNLMDECGMGMGGGASTITGHLSSLYPPTMSTANQQTSTTSSLIDAQYHNQYQQT 475
                                          |.||
Human   375 ------------------------------HCSS------------------------------- 378

  Fly   476 GGSLLDHPLTPTKFRQMTSTSSQTGQNGSGNGNGNGGYGGHGQSGGHHLYRQQSSCSANFSPLPQ 540
                                      .|||.|.|...|                     |...|
Human   379 --------------------------PGSGWGRGTDEY---------------------FIRKP- 395

  Fly   541 HAHQAHASTTTSDLGMANPNVIKSTTTVNSVATASTLADSCCSGTIQIHQGMGAGAACQSSELLH 605
                      .||.....||
Human   396 ----------PSDFLFPKPN--------------------------------------------- 405

  Fly   606 HQQLHHQQMHHQQQQQQQQQHHHHQRPTTSAAAAAAAAAAGGPSTSAAAAAAAAAAAAGTPPPPP 670
                                     |.....:|........||:.:.|
Human   406 -------------------------RFQPELSAPDLRRFIDGPNRAVA----------------- 428

  Fly   671 PPAGVCDILPACQREGGPHCCSGRGNVRQRWHTCPELHKAMDGVTYIADQTRKEEESTRVKEDWK 735
                                            ..|||.:.:..::|||.|.:::|:...:||||:
Human   429 --------------------------------LLPELREVVSSISYIARQLQEQEDHDALKEDWQ 461

  Fly   736 YVAMVLDRLFLWIFTIAVVVGTAGIILQA 764
            :||||:||||||.|.|...|||..|.|.|
Human   462 FVAMVVDRLFLWTFIIFTSVGTLVIFLDA 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	78/219 (36%)
		Neur_chan_memb	248..>359	CDD:280999	61/110 (55%)
		Neur_chan_memb	<683..760	CDD:280999	27/76 (36%)
CHRNB1	NP_000738.2	Neur_chan_LBD	27..245	CDD:308532	78/219 (36%)
		Neur_chan_memb	252..487	CDD:308533	117/512 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810