DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha3 and CHRNA7

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_001177384.1	Gene:	CHRNA7 / 1139	HGNCID:	1960	Length:	531	Species:	Homo sapiens

Alignment Length:	744	Identity:	219/744 - (29%)
Similarity:	308/744 - (41%)	Gaps:	276/744 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 KRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLKWEP 91
            ::||.:|:.|||.|.|||.|.:..|||...|.|.|::||:.|||::|||:|::.||.|:.|:|..
Human    56 RKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNV 120

  Fly    92 KEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVEWRPPAIYKSSCEIDVEY 156
            .||.||:.:..|...||:|||:|||:||..|:.|..|...:|.:|..::.||.|:||||.|||.:
Human   121 SEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRW 185

  Fly   157 FPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTSVEWDILEVPAVRNEKFY 221
            ||||.|.|.:|||||:|.|:.:||:..:           .|:|.:..:.|||::.:|..|:|:||
Human   186 FPFDVQHCKLKFGSWSYGGWSLDLQMQE-----------ADISGYIPNGEWDLVGIPGKRSERFY 239

  Fly   222 TCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSGEKVSLSISILLSLTVF 286
            .||.|||.|:||.:||||:||:|.:||:|||:.||.|.:|||.||:|||||:||.|::|||||||
Human   240 ECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVF 304

  Fly   287 FLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQTHTMAPWVRTVFINQLP 351
            .||:|||:|.||..|||:.::...|||:...|:.|||:||..|...|....|..|.|.:.:|...
Human   305 MLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCA 369

  Fly   352 RFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRDQIPPLPPPVALSRMHHSPKTTSRSTSPHLQH 416
            .||.|:||                    |   .|::.|                    ...|.|.
Human   370 WFLRMKRP--------------------G---EDKVRP--------------------ACQHKQR 391

  Fly   417 RVQTYNLMDECGMGMGGGASTITGHLSSLYPPTMSTANQQTSTTSSLIDAQYHNQYQQTGGSLLD 481
            |                 .|..:..:|::.||..|
Human   392 R-----------------CSLASVEMSAVAPPPAS------------------------------ 409

  Fly   482 HPLTPTKFRQMTSTSSQTGQNGSGNGNGNGGY-GGHGQSGGHHLYRQQSSCSANFSPLPQHAHQA 545
                                      |||..| |..|..|.|        |
Human   410 --------------------------NGNLLYIGFRGLDGVH--------C-------------- 426

  Fly   546 HASTTTSDLGMANPNVIKSTTTVNSVATASTLADSCCSGTIQIHQGMGAGAACQSSELLHHQQLH 610
               ..|.|.|:                   ......||.|                   |.:.|.
Human   427 ---VPTPDSGV-------------------VCGRMACSPT-------------------HDEHLL 450

  Fly   611 HQQMHHQQQQQQQQQHHHHQRPTTSAAAAAAAAAAGGPSTSAAAAAAAAAAAAGTPPPPPPPAGV 675
            |                                                   .|.||
Human   451 H---------------------------------------------------GGQPP-------- 456

  Fly   676 CDILPACQREGGPHCCSGRGNVRQRWHTCPELHKAMDGVTYIADQTRKEEESTRVKEDWKYVAMV 740
                     ||.                 |:|.|.::.|.|||::.|.::||..|..:||:.|.|
Human   457 ---------EGD-----------------PDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACV 495

  Fly   741 LDRLFLWIFTIAVVVGTAGIILQAPTLYD 769
            :|||.|..|::..::.|.||::.||...:
Human   496 VDRLCLMAFSVFTIICTIGILMSAPNFVE 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	98/213 (46%)
		Neur_chan_memb	248..>359	CDD:280999	56/110 (51%)
		Neur_chan_memb	<683..760	CDD:280999	23/76 (30%)
CHRNA7	NP_001177384.1	LIC	3..519	CDD:273305	217/737 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910