DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha3 and CHRNA5

DIOPT Version :10

Sequence 1:NP_525079.3 Gene:nAChRalpha3 / 31767 FlyBaseID:FBgn0015519 Length:795 Species:Drosophila melanogaster
Sequence 2:NP_000736.2 Gene:CHRNA5 / 1138 HGNCID:1959 Length:468 Species:Homo sapiens


Alignment Length:345 Identity:174/345 - (50%)
Similarity:239/345 - (69%) Gaps:15/345 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 LSFISSSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWV 78
            ||..||...:.|:  |..||..:|.:.||||.::.|.:.::..|.:|||:||:.|||:||||:|:
Human    37 LSEPSSIAKHEDS--LLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWL 99

  Fly    79 EQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVEWRPP 143
            :|.|.|.||:|.|.:|||::::.||||.:|.|||||::||||.||.| :||..:.|.|.|.|.||
Human   100 KQEWIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGT-STKTVIRYNGTVTWTPP 163

  Fly   144 AIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTSVEWD 208
            |.|||||.|||.:||||.|.|.||||||||||.|||:...|:         .||..:|:.:.||:
Human   164 ANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQ---------DVDKRDFFDNGEWE 219

  Fly   209 ILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSGEKV 273
            |:.....:..:..:||..||  :|::..::|..||||:.|||||:|:||||:|||||||:.|||:
Human   220 IVSATGSKGNRTDSCCWYPY--VTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKI 282

  Fly   274 SLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQTH-T 337
            .|..|:|:|||||.|::.||||.:|.|:||:|::::||||..|.||.|||..:|||.||..|| .
Human   283 CLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNA 347

  Fly   338 MAPWVRTVFINQLPRFLVMR 357
            |||.||.:|::.||:.|.||
Human   348 MAPLVRKIFLHTLPKLLCMR 367

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha3NP_525079.3 LGIC_ECD_nAChR_proto_alpha-like 25..243 CDD:349832 100/217 (46%)
Cys-loop 150..164 CDD:349832 9/13 (69%)
LGIC_TM_nAChR 242..>331 CDD:349866 55/88 (63%)
TM1 helix 242..266 CDD:349866 18/23 (78%)
TM2 helix 274..295 CDD:349866 11/20 (55%)
TM3 helix 306..328 CDD:349866 10/21 (48%)
Neur_chan_memb <683..760 CDD:460753
CHRNA5NP_000736.2 LGIC_ECD_nAChR_A5 45..251 CDD:349819 100/219 (46%)
Cys-loop 170..184 CDD:349819 9/13 (69%)
Neur_chan_memb 257..447 CDD:460753 66/111 (59%)
Blue background indicates that the domain is not in the aligned region.

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