DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha3 and CHRNA5

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_000736.2	Gene:	CHRNA5 / 1138	HGNCID:	1959	Length:	468	Species:	Homo sapiens

Alignment Length:	345	Identity:	174/345 - (50%)
Similarity:	239/345 - (69%)	Gaps:	15/345 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LSFISSSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWV 78
            ||..||...:.|:  |..||..:|.:.||||.::.|.:.::..|.:|||:||:.|||:||||:|:
Human    37 LSEPSSIAKHEDS--LLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWL 99

  Fly    79 EQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVEWRPP 143
            :|.|.|.||:|.|.:|||::::.||||.:|.|||||::||||.||.| :||..:.|.|.|.|.||
Human   100 KQEWIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGT-STKTVIRYNGTVTWTPP 163

  Fly   144 AIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTSVEWD 208
            |.|||||.|||.:||||.|.|.||||||||||.|||:...|:         .||..:|:.:.||:
Human   164 ANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQ---------DVDKRDFFDNGEWE 219

  Fly   209 ILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSGEKV 273
            |:.....:..:..:||..||  :|::..::|..||||:.|||||:|:||||:|||||||:.|||:
Human   220 IVSATGSKGNRTDSCCWYPY--VTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKI 282

  Fly   274 SLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQTH-T 337
            .|..|:|:|||||.|::.||||.:|.|:||:|::::||||..|.||.|||..:|||.||..|| .
Human   283 CLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNA 347

  Fly   338 MAPWVRTVFINQLPRFLVMR 357
            |||.||.:|::.||:.|.||
Human   348 MAPLVRKIFLHTLPKLLCMR 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	99/214 (46%)
		Neur_chan_memb	248..>359	CDD:280999	66/111 (59%)
		Neur_chan_memb	<683..760	CDD:280999
CHRNA5	NP_000736.2	LIC	39..449	CDD:273305	172/343 (50%)
		Neur_chan_LBD	47..250	CDD:280998	100/216 (46%)
		Neur_chan_memb	257..447	CDD:280999	66/111 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	251	1.000	Domainoid score	I2107
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4201
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.770