DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha3 and CHRNA1

DIOPT Version :10

Sequence 1:NP_525079.3 Gene:nAChRalpha3 / 31767 FlyBaseID:FBgn0015519 Length:795 Species:Drosophila melanogaster
Sequence 2:XP_016858745.1 Gene:CHRNA1 / 1134 HGNCID:1955 Length:489 Species:Homo sapiens


Alignment Length:424 Identity:189/424 - (44%)
Similarity:254/424 - (59%) Gaps:51/424 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 ILVLSFISSS--TANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMT 73
            :||.|.:|:.  ..:....||...|..:|:.:||||.:....:.|.:.|:|.|||:|:..|||:|
Human    14 VLVSSAVSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVT 78

  Fly    74 TNLWVEQ-------------------------SWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIV 113
            ||:.::|                         .|.||.|||.|.:||||:.:|:||:.|||||:|
Human    79 TNVRLKQGDMVDLPRPSCVTLGVPLFSHLQNEQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLV 143

  Fly   114 LYNNADGNFEVTLATKATLNYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQV 178
            |||||||:|.:...||..|.|||.:.|.||||:||.|||.|.:||||||.|.||.|:|||||..|
Human   144 LYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVV 208

  Fly   179 DLRHIDELNGTNVVEVGVDLSEFYTSVEWDILEVPAVRNEKFYTCC-DEPYLDITFNITMRRKTL 242
            .:         |......|||.|..|.||.|.|....::...|:|| |.||||||::..|:|..|
Human   209 AI---------NPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPL 264

  Fly   243 FYTVNLIIPCMGISFLTILVFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKF 307
            ::.||:||||:..||||.||||||:|||||::||||:|||||||.|::.|:||.||..|||:||:
Human   265 YFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKY 329

  Fly   308 VLFTMILDTFSICVTVLVLNIHFRSPQTHTMAPWVRTVFINQLPR---FLVMRRPLYPISEMIKS 369
            :||||:....||.:||:|:|.|.|||.||.|..|||.|||:.:|.   |..|:||     ...|.
Human   330 MLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRP-----SREKQ 389

  Fly   370 SRRLMVRTCNGLELRDQIPPLPPPVALSRMHHSP 403
            .:::.....:..::..:  |.|||:..    |||
Human   390 DKKIFTEDIDISDISGK--PGPPPMGF----HSP 417

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha3NP_525079.3 LGIC_ECD_nAChR_proto_alpha-like 25..243 CDD:349832 105/243 (43%)
Cys-loop 150..164 CDD:349832 10/13 (77%)
LGIC_TM_nAChR 242..>331 CDD:349866 55/88 (63%)
TM1 helix 242..266 CDD:349866 15/23 (65%)
TM2 helix 274..295 CDD:349866 13/20 (65%)
TM3 helix 306..328 CDD:349866 10/21 (48%)
Neur_chan_memb <683..760 CDD:460753
CHRNA1XP_016858745.1 LGIC_ECD_nAChR_A1 29..263 CDD:349815 105/242 (43%)
Cys-loop 180..194 CDD:349815 10/13 (77%)
Neur_chan_memb 270..478 CDD:460753 77/159 (48%)
Blue background indicates that the domain is not in the aligned region.

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