DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha3 and Chrna2

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_659052.1	Gene:	Chrna2 / 110902	MGIID:	87886	Length:	512	Species:	Mus musculus

Alignment Length:	767	Identity:	258/767 - (33%)
Similarity:	339/767 - (44%)	Gaps:	278/767 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FQVTIDMIL--------VLSFISSSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLS 60
            ||..|.:.|        ||:...|.|...|  ||:..|...||:..|||.|.:|.:.||..|.::
Mouse     8 FQFWIHLYLWCLLLMPAVLAQQGSHTHAED--RLFKHLFGGYNRWARPVPNTSDVVIVRFGLSIA 70

  Fly    61 QLIDVNLKNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVT 125
            |||||:.|||:||||:|::|.|.||||:|:|.|:|.:..|.|||:.||.|||||||||||.|.||
Mouse    71 QLIDVDEKNQMMTTNVWLKQEWNDYKLRWDPAEFGNITSLRVPSEMIWIPDIVLYNNADGEFAVT 135

  Fly   126 LATKATLNYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTN 190
            ..|||.|.:||.|.|.|||||||||.|||.:||||:|.|.|||||||||..::||..::..
Mouse   136 HMTKAHLFFTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMERT---- 196

  Fly   191 VVEVGVDLSEFYTSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGI 255
                 |||.:::.|.||.|:......|.|.|.||.|.|.|:|:...:||..||||:||||||:.|
Mouse   197 -----VDLKDYWESGEWAIINATGTYNSKKYDCCAEIYPDVTYYFVIRRLPLFYTINLIIPCLLI 256

  Fly   256 SFLTILVFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSIC 320
            |.||:|||||||:.|||::|.||:|||||||.||:.||||.||||:||:|:::|||||..|.||.
Mouse   257 SCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIV 321

  Fly   321 VTVLVLNIHFRSPQTHTMAPWVRTVFINQLPRFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRD 385
            :||.|||:|.|||.||.|..|||...:.::||:|:|.|||
Mouse   322 ITVFVLNVHHRSPSTHNMPNWVRVALLGRVPRWLMMNRPL------------------------- 361

  Fly   386 QIPPLPPPVALSRMHHSPKTTSRSTSPHLQHRVQTYNLMDECGMGMGGGASTITGHLSSLYPPTM 450
              ||:       .:|.||   ....||       ||:.::
Mouse   362 --PPM-------ELHGSP---GLKLSP-------TYHWLE------------------------- 382

  Fly   451 STANQQTSTTSSLIDAQYHNQYQQTGGSLLDHPLTPTKFRQMTSTSSQTGQNGSGNGNGNGGYGG 515
                       :.:||:.                     |:.|....:..::
Mouse   383 -----------TNMDAEE---------------------REETEEEEEEEED------------- 402

  Fly   516 HGQSGGHHLYRQQSSCSANFSPLPQHAHQAHASTTTSDLGMANPNVIKSTTTVNSVATASTLADS 580
                                                                 .::...:.|.||
Mouse   403 -----------------------------------------------------ENICMCAGLPDS 414

  Fly   581 CCSGTIQIHQGMGAGAACQSSELLHHQQLHHQQMHHQQQQQQQQQHHHHQRPTTSAAAAAAAAAA 645
                      .||.        |..|..||.:.|
Mouse   415 ----------SMGV--------LYGHGSLHLRAM------------------------------- 430

  Fly   646 GGPSTSAAAAAAAAAAAAGTPPPPPPPAGVCDILPACQREGGPHCCSGRGNVRQRWHTCPELHKA 710
             ||....                   |:...:||                       ..|::.||
Mouse   431 -GPEAKT-------------------PSQASEIL-----------------------LSPQIQKA 452

  Fly   711 MDGVTYIADQTRKEEESTRVKEDWKYVAMVLDRLFLWIFTIAVVVGTAGIIL 762
            ::||.||||..|.|:..:.|||||||||||:||:|||:|.|...:||.|:.|
Mouse   453 LEGVHYIADHLRSEDADSSVKEDWKYVAMVVDRIFLWLFIIVCFLGTIGLFL 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	111/214 (52%)
		Neur_chan_memb	248..>359	CDD:280999	69/110 (63%)
		Neur_chan_memb	<683..760	CDD:280999	31/76 (41%)
Chrna2	NP_659052.1	LIC	15..505	CDD:273305	255/760 (34%)
		LGIC_ECD_nAChR_A2	36..242	CDD:349816	112/216 (52%)
		Cys-loop	160..174	CDD:349816	9/13 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	253	1.000	Domainoid score	I2060
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	476	1.000	Inparanoid score	I1470
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	1	1.000	-	-		FOG0000583
OrthoInspector	1	1.000	-	-		mtm8871
orthoMCL	1	0.900	-	-		OOG6_101158
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X294
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.770