DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha3 and Chrna5

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_001360830.1	Gene:	Chrna5 / 110835	MGIID:	87889	Length:	467	Species:	Mus musculus

Alignment Length:	342	Identity:	172/342 - (50%)
Similarity:	242/342 - (70%)	Gaps:	15/342 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 ISSSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQS 81
            :||:..:.|:  |:.||..:|.|.||||.:::|.:.::..|.:|||:||:.|||:||||:|::|.
Mouse    40 LSSAAKHEDS--LFRDLFEDYEKWVRPVEHLSDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQE 102

  Fly    82 WYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVEWRPPAIY 146
            |.|.||:|.|.:|||::::.||||.:|.|||||::||||.|| ..:||..:.|.|.|.|..||.|
Mouse   103 WIDVKLRWNPDDYGGIKIIRVPSDSLWIPDIVLFDNADGRFE-GASTKTVVRYNGTVTWTQPANY 166

  Fly   147 KSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTSVEWDILE 211
            ||||.|||.:||||.|.|.||||||||||.|||:...|:         .||.::|:.:.||:|:.
Mouse   167 KSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQ---------DVDRTDFFDNGEWEIMS 222

  Fly   212 VPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSGEKVSLS 276
            ....:..:..:||..|.  ||::..::|..||||:.|||||:|:||||::||||||:.|||:||.
Mouse   223 AMGSKGNRTDSCCWYPC--ITYSFVIKRLPLFYTLFLIIPCIGLSFLTVVVFYLPSNEGEKISLC 285

  Fly   277 ISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQTH-TMAP 340
            .|:|:|||||.|::.||||.:|.|:||:|::::||||..|.||.|||..:|||.||..|| .|||
Mouse   286 TSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAP 350

  Fly   341 WVRTVFINQLPRFLVMR 357
            |||.:|:::||:.|.||
Mouse   351 WVRKIFLHKLPKLLCMR 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	98/214 (46%)
		Neur_chan_memb	248..>359	CDD:280999	67/111 (60%)
		Neur_chan_memb	<683..760	CDD:280999
Chrna5	NP_001360830.1	LGIC_ECD	45..251	CDD:355788	99/219 (45%)
Chrna5	NP_001360830.1	Neur_chan_memb	257..445	CDD:367256	67/111 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	253	1.000	Domainoid score	I2060
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4201
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.770