DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha3 and Chrnb4

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_683746.1	Gene:	Chrnb4 / 108015	MGIID:	87892	Length:	495	Species:	Mus musculus

Alignment Length:	756	Identity:	235/756 - (31%)
Similarity:	331/756 - (43%)	Gaps:	291/756 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ANPDAKRLYDDLL--SNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWYD 84
            ||.:.| |.||||  :.||.|:||..:.:..:::|::|.|||||.||.:.|||||::|::|.|.|
Mouse    23 ANAEEK-LMDDLLNKTRYNNLIRPATSSSQLISIRLELSLSQLISVNEREQIMTTSIWLKQEWTD 86

  Fly    85 YKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVEWRPPAIYKSS 149
            |:|.|....|.||.:|.:|:..:|.|||||||||||.:||::.|...:...|.::|.|||||||:
Mouse    87 YRLAWNSSCYEGVNILRIPAKRVWLPDIVLYNNADGTYEVSVYTNVIVRSNGSIQWLPPAIYKSA 151

  Fly   150 CEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTSVEWDILEVPA 214
            |:|:|::||||:|.|.:||.|||||..::|:    .|.....:     :.:|..|.||||:.:|.
Mouse   152 CKIEVKHFPFDQQNCTLKFRSWTYDHTEIDM----VLKSPTAI-----MDDFTPSGEWDIVALPG 207

  Fly   215 VR--NEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSGEKVSLSI 277
            .|  |.:     |..|:|:|::..::||.||||:||||||:.|:.|.|||||||||.|||::|.|
Mouse   208 RRTVNPQ-----DPSYVDVTYDFIIKRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCI 267

  Fly   278 SILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQTHTMAPWV 342
            |:||:||.|.||:::|:|||||.:||:||::||||:|.||||..||.|||:|.|||.|||||.||
Mouse   268 SVLLALTFFLLLISKIVPPTSLDIPLIGKYLLFTMVLVTFSIVTTVCVLNVHHRSPSTHTMASWV 332

  Fly   343 RTVFINQLPRFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRDQIPPLPPPVALSRMHHSPKTTS 407
            :..|:::||.||.|:||                    |||:                  ||....
Mouse   333 KECFLHKLPTFLFMKRP--------------------GLEV------------------SPARVP 359

  Fly   408 RSTSPHLQHRVQTYNLMDECGMGMGGGASTITGHLSSLYPPTMSTANQQTSTTSSLIDAQYHNQY 472
            .|:..||                                            ||:
Mouse   360 HSSQLHL--------------------------------------------TTA----------- 369

  Fly   473 QQTGGSLLDHPLTPTKFRQMTSTSSQTGQNGSGNGNGNGGYGGHGQSGGHHLYRQQSSCSANFSP 537
                              :.||||: .|.:...|..||..|                    ..:|
Mouse   370 ------------------EATSTSA-LGPSSPSNLYGNSMY--------------------FVNP 395

  Fly   538 LPQHAHQAHASTTTSDLGMANPNVIKSTTTVNSVATASTLADSCCSGTIQIHQGMGAGAACQSSE 602
            :|                 |.|....|:.|.                      |:...|..:||
Mouse   396 VP-----------------ATPKSAVSSHTA----------------------GLPRDARLRSS- 420

  Fly   603 LLHHQQLHHQQMHHQQQQQQQQQHHHHQRPTTSAAAAAAAAAAGGPSTSAAAAAAAAAAAAGTPP 667

Mouse   421 ----------------------------------------------------------------- 420

  Fly   668 PPPPPAGVCDILPACQREGGPHCCSGRGNVRQRWHTCPELHKAMDGVTYIADQTRKEEESTRVKE 732
                                       |..||      :|.:|::||::||.....::....|.|
Mouse   421 ---------------------------GRFRQ------DLQEALEGVSFIAQHLESDDRDQSVIE 452

  Fly   733 DWKYVAMVLDRLFLWIFTIAVVVGTAGIILQAPTLYDTRMP 773
            |||:||||:||||||:|.|..::||.|:.|  |.|:....|
Mouse   453 DWKFVAMVVDRLFLWVFVIVCILGTMGLFL--PPLFQIHAP 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	93/218 (43%)
		Neur_chan_memb	248..>359	CDD:280999	70/110 (64%)
		Neur_chan_memb	<683..760	CDD:280999	28/76 (37%)
Chrnb4	NP_683746.1	LIC	21..483	CDD:273305	232/746 (31%)
		Neur_chan_LBD	26..231	CDD:280998	93/219 (42%)
		Neur_chan_memb	238..481	CDD:280999	130/512 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm11113
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820