DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha3 and LOC101732933

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	XP_031754974.1	Gene:	LOC101732933 / 101732933	-ID:	-	Length:	498	Species:	Xenopus tropicalis

Alignment Length:	761	Identity:	238/761 - (31%)
Similarity:	341/761 - (44%)	Gaps:	291/761 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 MILVLSFISSSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTT 74
            :.|...|..|:..:    |||:|||.:||..:|||:||:|.:.:..::.:|||:.|:..||||.|
Frog    25 LFLSAGFFCSNVEH----RLYEDLLKSYNPYIRPVMNVSDPVILHFEVSMSQLVKVDEVNQIMET 85

  Fly    75 NLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVE 139
            |||:...|.||||||.|.:|||:|.|.:|:..||||||||||||.|.|.|....||.:.|:|.|.
Frog    86 NLWLRHLWNDYKLKWNPSDYGGIEFLRIPASQIWRPDIVLYNNAVGAFHVDDKAKAVVRYSGDVT 150

  Fly   140 WRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVG--VDLSEFY 202
            |.||||:||||:|||.:||||.|.|.:||||||||..::           |:|.:|  ::|.||:
Frog   151 WIPPAIFKSSCKIDVTFFPFDYQNCSLKFGSWTYDKAKI-----------NLVMIGSKINLKEFW 204

  Fly   203 TSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPS 267
            .|.||.|:..|..::|..|.||.|.|.|||:::.:||..||||:.:||||:.||.||||||||||
Frog   205 ESGEWVIINAPGYKHEIKYNCCVEIYQDITYSLYIRRLPLFYTIYIIIPCLLISCLTILVFYLPS 269

  Fly   268 DSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRS 332
            |.||||:|.:|:|||||||.|::.||||.||||:||:|:::|||||..|.||.:||.|||:|:|:
Frog   270 DCGEKVTLCMSVLLSLTVFLLVITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRT 334

  Fly   333 PQTHTMAPWVRTVFINQLPRFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRDQIPPLPPPVALS 397
            |:||||..||:..|::.||:.:.|.||                         ::.|
Frog   335 PKTHTMPHWVKRFFLHLLPKVMFMTRP-------------------------EKQP--------- 365

  Fly   398 RMHHSPKTTSRSTSPHLQHRVQTYNLMDECGMGMGGGASTITGHLSSLYPPTMSTANQQTSTTSS 462

Frog   366 ----------------------------------------------------------------- 365

  Fly   463 LIDAQYHNQYQQTGGSLLDHPLTPTKFRQMTSTSSQTGQNGSGNGNGNGGYGGHGQSGGHHLYRQ 527
                               :.|.|..:..::|:..::.|:                    .|:.|
Frog   366 -------------------YALKPQAYLDISSSEIRSCQD--------------------QLFYQ 391

  Fly   528 QSSCSANFSPLPQHAHQAHASTTTSDLGMANPNVIKSTTTVNSVATASTLADSCCSGTIQIHQGM 592
            .|||:.                          ..:|...|          :|:.|:.|    :|
Frog   392 DSSCAC--------------------------GQLKRLYT----------SDTACNVT----RG- 415

  Fly   593 GAGAACQSSELLHHQQLHHQQMHHQQQQQQQQQHHHHQRPTTSAAAAAAAAAAGGPSTSAAAAAA 657
                  .|.|.:::..||
Frog   416 ------SSLESMYNLGLH----------------------------------------------- 427

  Fly   658 AAAAAAGTPPPPPPPAGVCDILPACQREGGPHCCSGRGNVRQRWHTCPELHKAMDGVTYIADQTR 722
                                              ||.|       ..||:.:|::.|.:||:..:
Frog   428 ----------------------------------SGSG-------LSPEIREAIEDVHFIAENMK 451

  Fly   723 KEEESTRVKEDWKYVAMVLDRLFLWIFTIAVVVGTAGIILQAPTLY 768
            .::|:..|::||||||||:||:|||:|.:..::||||:.|| |.|:
Frog   452 AQDEAKEVQDDWKYVAMVIDRIFLWVFVLVCILGTAGLFLQ-PLLF 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	108/216 (50%)
		Neur_chan_memb	248..>359	CDD:280999	68/110 (62%)
		Neur_chan_memb	<683..760	CDD:280999	28/76 (37%)
LOC101732933	XP_031754974.1	LIC	34..491	CDD:273305	232/744 (31%)
LOC101732933	XP_031754974.1	LGIC_ECD_nAChR_A3	37..243	CDD:349817	108/220 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2037
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	477	1.000	Inparanoid score	I1443
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	1	1.000	-	-		FOG0000583
OrthoInspector	1	1.000	-	-		mtm14085
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X294
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060