DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha3 and htr3a

DIOPT Version :10

Sequence 1:NP_525079.3 Gene:nAChRalpha3 / 31767 FlyBaseID:FBgn0015519 Length:795 Species:Drosophila melanogaster
Sequence 2:XP_031762490.1 Gene:htr3a / 101731577 XenbaseID:XB-GENE-990708 Length:474 Species:Xenopus tropicalis


Alignment Length:362 Identity:115/362 - (31%)
Similarity:196/362 - (54%) Gaps:30/362 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 MILVLSFISSSTAN------PDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLK 68
            ::|:||.:....||      |...||.|.|:..|.|.||||::.....||.|.:.:..::.|:.|
 Frog    11 VVLILSLLIPCYANVNRSSKPTLLRLSDHLMEGYKKGVRPVLDWRQTTTVYIDVMVYAILGVDEK 75

  Fly    69 NQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLN 133
            ||::||.:|..|.|.|..|.|:||::..|..:.:|::.||.|||::....|......: ....:|
 Frog    76 NQVLTTYIWYRQFWVDEFLTWDPKKFENVSQISIPTEKIWVPDILINEFVDVGKSPDI-PYVYVN 139

  Fly   134 YTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSW--TYDGFQVDLRHIDELNGTNVVEVGV 196
            :.|||:...|....::|.:::..||||.|.|.:.|.||  |.....|.|....|       ||..
 Frog   140 HEGRVQNYKPIQVVTACSLNIYNFPFDVQNCSLTFTSWLHTIQDINVSLWRTPE-------EVKE 197

  Fly   197 DLSEFYTSVEWDILEVPA-----VRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGIS 256
            |.|.|..:.||::|.|.:     |.||       :.:.::.|::.::|:.|||.|||::|.|.:.
 Frog   198 DKSLFMNNGEWELLSVLSQYRKFVENE-------DSFAEMKFHVVIKRRPLFYAVNLLLPSMFLM 255

  Fly   257 FLTILVFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICV 321
            .:.|:.||||.||||:||..|::||..:||.:::::.:|.|::..||:|.:.:..|.|...|:..
 Frog   256 VMDIIGFYLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLTE 320

  Fly   322 TVLVLN-IHFRSPQTHTMAPWVRTVFINQLPRFLVMR 357
            |:|::. :|.:..||| :..|::.:.:.::...|.:|
 Frog   321 TILIVRLVHKQDLQTH-VPEWLKRLVLEKITALLCIR 356

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha3NP_525079.3 LGIC_ECD_nAChR_proto_alpha-like 25..243 CDD:349832 68/224 (30%)
Cys-loop 150..164 CDD:349832 6/13 (46%)
LGIC_TM_nAChR 242..>331 CDD:349866 35/89 (39%)
TM1 helix 242..266 CDD:349866 11/23 (48%)
TM2 helix 274..295 CDD:349866 6/20 (30%)
TM3 helix 306..328 CDD:349866 5/22 (23%)
Neur_chan_memb <683..760 CDD:460753
htr3aXP_031762490.1 LIC 13..468 CDD:455710 115/360 (32%)
LGIC_ECD_5-HT3A 33..239 CDD:349812 67/220 (30%)
Cys-loop 156..170 CDD:349812 6/13 (46%)
Blue background indicates that the domain is not in the aligned region.

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