Protein Alignment nAChRalpha3 and LOC100537401

DIOPT Version :10

• Sequence 1: NP_525079.3
• Gene: nAChRalpha3 / 31767
• FlyBaseID: FBgn0015519
• Length: 795
• Species: Drosophila melanogaster
• Sequence 2: XP_021333008.2
• Gene: LOC100537401 / 100537401
• -ID: -
• Length: 552
• Species: Danio rerio
• Alignment Length: 745
• Identity: 239/745 - (32%)
• Similarity: 338/745 - (45%)
• Gaps: 234/745 - (31%)

  Fly    27 KRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLKWE- 90
            :||.:.|||.|:||.|||.:|:|.:.|...|.::|||||:.|||:||||:||:|.|.||:|:|.
Zfish    25 ERLLNSLLSAYSKLTRPVHSVSDVVHVHFGLSIAQLIDVDEKNQMMTTNVWVKQEWLDYRLRWTP 89

  Fly    91 -PKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVEWRPPAIYKSSCEIDV 154
             |::.|.|..:.:|:..||:|||||||||||:|.||..|||.|.:.|||.|.|||||||||.|||
Zfish    90 GPEDNGNVSSMRIPAQFIWKPDIVLYNNADGDFTVTHLTKAHLLHDGRVTWIPPAIYKSSCSIDV 154

  Fly   155 EYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTSVEWDILEVPAVRNEK 219
            .:.|||:|.|.:||||||||..::||..|.:         .||..:::.|.||.|....|..|.|
Zfish   155 TFLPFDQQNCTIKFGSWTYDRSKIDLIRIAD---------SVDQLDYWESGEWLITSAVATYNVK 210

  Fly   220 FYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSGEKVSLSISILLSLT 284
            .|.||.|.|.|||::..:||..||||:||||||:.|..||:||||||||.||:|::.||:|||||
Zfish   211 KYECCSEEYADITYSFIIRRLPLFYTINLIIPCLLILCLTVLVFYLPSDCGEEVTMCISVLLSLT 275

  Fly   285 VFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQTHTMAPWVRTVFINQ 349
            ||.||:.|||||||||:||:.:::||.||.....|.:||.|||:|.|||.||:|..|||..|::.
Zfish   276 VFLLLITEIIPPTSLVIPLIAEYLLFIMIFIILFIIITVFVLNVHHRSPDTHSMPQWVRRFFLDV 340

  Fly   350 LPRFLVMRRPLY-------PISEMIKSSRRLMVRTCNGLELRDQIPPLPPPVALSRMHHSPKTTS 407
            :|||:.::||..       ...:..||::|.:.......|::::
Zfish   341 MPRFIFIQRPQIWQKDAKGVCDDAQKSNKRCVDSNWKNREIKEE--------------------- 384

  Fly   408 RSTSPHLQHRVQTYNLMDECGMGMGGGASTITGHLSSLYPPTMSTANQQTSTTSSLIDAQYHNQY 472
                   ..|::.|                                       ||.::|..|:
Zfish   385 -------SIRMKVY---------------------------------------SSCLNADMHS-- 401

  Fly   473 QQTGGSLLDHPLTPTKFRQMTSTSSQTGQNGSGNGNGNGGYGGHGQSGGHHLYRQQSSCSANFSP 537
                                ..:.||...|                          |:|.
Zfish   402 --------------------IKSPSQAYNN--------------------------STCP----- 415

  Fly   538 LPQHAHQAHASTTTSDLGMANPNVIKSTTTVNSVATASTLADSCCSGTIQIHQGMGAGAACQSSE 602
             ....|:..:.:...:.|..:.|:                                    |.||.
Zfish   416 -KMKLHKGRSQSVQVNCGERDVNL------------------------------------CNSST 443

  Fly   603 LLHHQQLHHQQMHHQQQQQQQQQHHHHQRPTTSAAAAAAAAAAGGPSTSAAAAAAAAAAAAGTPP 667
            ....:.:.:..:|..:||                             |||...|...
Zfish   444 RFRSRSMQYCSLHEHEQQ-----------------------------TSAVFNADKF-------- 471

  Fly   668 PPPPPAGVCDILPACQREGGPHCCSGRGNVRQRWHTCPELHKAMDGVTYIADQTRKEEESTRVKE 732
                 :.:|.::.: ..|...|.                ...|::||.|||:..|.:.....|||
Zfish   472 -----SNICKVMTS-TGENPSHA----------------TRLAIEGVQYIAEYLRAQHADLSVKE 514

  Fly   733 DWKYVAMVLDRLFLWIFTIAVVVGTAGIIL 762
            :|||||||:||||||:|.:..::|..|:.:
Zfish   515 EWKYVAMVIDRLFLWMFVLVCILGIVGLFI 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_525079.3	LGIC_ECD_nAChR_proto_alpha-like	25..243	CDD:349832	110/217 (51%)
		Cys-loop	150..164	CDD:349832	8/13 (62%)
		LGIC_TM_nAChR	242..>331	CDD:349866	57/88 (65%)
		TM1 helix	242..266	CDD:349866	17/23 (74%)
		TM2 helix	274..295	CDD:349866	13/20 (65%)
		TM3 helix	306..328	CDD:349866	9/21 (43%)
		Neur_chan_memb	<683..760	CDD:460753	27/76 (36%)
LOC100537401	XP_021333008.2	None