DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha3 and chrng

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_001241879.1	Gene:	chrng / 100536659	ZFINID:	ZDB-GENE-030131-3805	Length:	540	Species:	Danio rerio

Alignment Length:	354	Identity:	146/354 - (41%)
Similarity:	215/354 - (60%)	Gaps:	13/354 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ILVLSFISSSTANPDAKRLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTN 75
            ||:..| |.:..|.:.. |:.||:..|||.:|||.:..|.:.|:||:.|:.||.:|.|.:.:||.
Zfish    14 ILLFRF-SGALCNLEGS-LHRDLMVGYNKNIRPVESHEDIIDVKIKMTLTNLISLNEKEETLTTC 76

  Fly    76 LWVEQSWYDYKLKWEPKE----YGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTG 136
            :|:|..|.||:|:|..:.    |..:..:.:||..||.|||.|.||.||.|||.|.....::..|
Zfish    77 VWIEMQWRDYRLRWANRTGFEVYENITRMRLPSKTIWLPDIGLENNVDGRFEVALYANTLIDPDG 141

  Fly   137 RVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEF 201
            .|.|.|||||:|||.|.|.|||||.|.|.|.|.|.||:..::.|...||.|.| :..:.:|...|
Zfish   142 SVYWLPPAIYRSSCAIKVNYFPFDWQNCSMVFRSQTYNSNEITLMLSDEDNVT-MEWIEIDPEAF 205

  Fly   202 YTSVEWDILEVPA--VRNEKFYTCCDE-PYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVF 263
            ..:.||.|...||  |.|:::..  || .:.:|.|.:.::||.|||.:|:|:||:..|.|.:||:
Zfish   206 TENGEWMIKHRPAKKVINKRYRP--DELEHQEIIFFLIIQRKPLFYVINIIVPCVLFSSLGLLVY 268

  Fly   264 YLPSDS-GEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLN 327
            :||:.: |:|.:::|.|||..|||..|:|:.:|.||..|||:||:::|.|.:.|.::...|:|||
Zfish   269 FLPAKAGGQKCTMTICILLGQTVFLFLIAKKVPETSQAVPLIGKYLMFVMSVTTITVMNCVVVLN 333

  Fly   328 IHFRSPQTHTMAPWVRTVFINQLPRFLVM 356
            :..|:|.||.|:..:|.|.:|.|||.|.|
Zfish   334 VSLRTPNTHPMSNTIRKVLLNILPRVLRM 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	88/221 (40%)
		Neur_chan_memb	248..>359	CDD:280999	48/110 (44%)
		Neur_chan_memb	<683..760	CDD:280999
chrng	NP_001241879.1	LIC	21..511	CDD:273305	142/346 (41%)
		Neur_chan_LBD	27..246	CDD:280998	88/222 (40%)
		Neur_chan_memb	253..509	CDD:280999	48/110 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3645
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810