DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nAChRalpha3 and chrnb4

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	XP_012822341.1	Gene:	chrnb4 / 100497893	XenbaseID:	XB-GENE-985370	Length:	481	Species:	Xenopus tropicalis

Alignment Length:	771	Identity:	239/771 - (30%)
Similarity:	337/771 - (43%)	Gaps:	305/771 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 MILVLSFISSSTANPDAKRLYDDLL--SNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIM 72
            ::..|.:::...|....:||.::||  ..||||:||..|.:..::::::|.|:|||.||.:.|||
Frog    10 LLTALLWVNCCKAADSEERLMNNLLRKDKYNKLIRPAYNNSQLVSIQLQLSLAQLISVNEREQIM 74

  Fly    73 TTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGR 137
            |||:|:.|.|.||:|.|.|.:|.|::.|.:||..||.|||||||||||.:||:|.|.|.:...|.
Frog    75 TTNVWLNQEWVDYRLTWNPADYDGIKKLRIPSQQIWLPDIVLYNNADGTYEVSLFTNAIVQNNGS 139

  Fly   138 VEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVG-VDLSEF 201
            |.|.|||||||:|:|:|::||||:|.|.:||.|||||..::||          |:..| ..:.:|
Frog   140 VAWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDYTEIDL----------VLNKGWATMDDF 194

  Fly   202 YTSVEWDILEVPAVRNEKFYTCC--DEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFY 264
            ..|.||||:|:|..|     |.|  |..|:|:|::..::||.||||:||||||:.|:.|.|||||
Frog   195 TPSGEWDIIELPGRR-----TICPLDPTYVDVTYDFIIKRKPLFYTINLIIPCILITSLAILVFY 254

  Fly   265 LPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIH 329
            ||||.|:|::|.||:||:||||.||:::|:|||||.|||:||:::|||:|.||||..:|.|||:|
Frog   255 LPSDCGQKMTLCISVLLALTVFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVH 319

  Fly   330 FRSPQTHTMAPWVRTVFINQLPRFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRDQIPPLPPPV 394
            .|||.||||.|||:..|:::||.||.|:||     |...:|::|
Frog   320 HRSPSTHTMPPWVKNCFLDRLPVFLFMKRP-----ENSSASQKL--------------------- 358

  Fly   395 ALSRMHHSPKTTSRSTSPHLQHRVQTYNLMDECGMGMGGGASTITGHLSSLYPPTMSTANQQTST 459
                         ||...::|                      |....:|.|...|:||..
Frog   359 -------------RSYRRNMQ----------------------IESFRNSNYFVNMTTARP---- 384

  Fly   460 TSSLIDAQYHNQYQQTGGSLLDHPLTPTKFRQMTSTSSQTGQNGSGNGNGNGGYGGHGQSGGHHL 524
                                .||
Frog   385 --------------------CDH------------------------------------------ 387

  Fly   525 YRQQSSCSANFSPLPQHAHQAHASTTTSDLGMANPNVIKSTTTVNSVATASTLADSCCSGTIQIH 589
                                                      |||
Frog   388 ------------------------------------------TVN-------------------- 390

  Fly   590 QGMGAGAACQSSELLHHQQLHHQQMHHQQQQQQQQQHHHHQRPTTSAAAAAAAAAAGGPSTSAAA 654
                     ...|.:.||:..::                :.|..|
Frog   391 ---------DPPESVRHQEFRYR----------------YPRKYT-------------------- 410

  Fly   655 AAAAAAAAAGTPPPPPPPAGVCDILPACQREGGPHCCSGRGNVRQRWHTCPELHKAMDGVTYIAD 719
                                                              ||:|:|||||.:|::
Frog   411 --------------------------------------------------PEVHEAMDGVKFISE 425

  Fly   720 QTRKEEESTRVKEDWKYVAMVLDRLFLWIFTIAVVVGTAGIILQAPTLYDTRMPID 775
            ..:.|:|...:.|||||||||:||||||||.|..:|||.|:.:| |.:.:...|.|
Frog   426 HMKSEDEDQSIIEDWKYVAMVVDRLFLWIFIIVCIVGTVGLFMQ-PLIQNHTPPDD 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	101/219 (46%)
		Neur_chan_memb	248..>359	CDD:280999	69/110 (63%)
		Neur_chan_memb	<683..760	CDD:280999	32/76 (42%)
chrnb4	XP_012822341.1	LIC	21..468	CDD:273305	234/745 (31%)
chrnb4	XP_012822341.1	LGIC_ECD	53..230	CDD:355788	89/191 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	233	1.000	Domainoid score	I2339
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm14085
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010