DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha3 and chrnb3

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	XP_002942943.1	Gene:	chrnb3 / 100379831	XenbaseID:	XB-GENE-5793509	Length:	460	Species:	Xenopus tropicalis

Alignment Length:	359	Identity:	182/359 - (50%)
Similarity:	243/359 - (67%)	Gaps:	23/359 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 IDMILVLSFISSSTA--NPDAK---RLYDDLLSNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNL 67
            :.:.:.:.||:|..|  :|.|:   .|...|.:.|.|.||||:|....:.|...||:|||:||:.
Frog     8 LSLSITVYFINSGFAKFHPLAEIEDALLRKLFAGYQKWVRPVLNPNSTIKVNFGLKISQLVDVDE 72

  Fly    68 KNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATL 132
            |.|:||||:|:.|.|.|.||:|.||:|||:..:.|||:.:|.|||||:.||||.||.:|.|||.:
Frog    73 KKQLMTTNVWLRQEWMDMKLRWNPKDYGGITYIRVPSESLWLPDIVLFENADGRFEGSLMTKAII 137

  Fly   133 NYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVD 197
            .|.|.|.|.|||.|||||.:||.:||||.|.|.||||||||||..|||..:||         .||
Frog   138 KYDGTVTWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGNMVDLILLDE---------NVD 193

  Fly   198 LSEFYTSVEWDILE---VPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLT 259
            ..:|:.:.|||||.   :..:|.:..|:     |..||::..:||..||||:.|||||:|:||||
Frog   194 RKDFFDNGEWDILNATGLKGMRKDGLYS-----YPFITYSFVLRRLPLFYTLFLIIPCLGLSFLT 253

  Fly   260 ILVFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVL 324
            :||||||||.|||:|||.|:|:|||||.|::.||||.:|.|:||:|:::||.||..|.||.|||.
Frog   254 VLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVF 318

  Fly   325 VLNIHFRSPQT-HTMAPWVRTVFINQLPRFLVMR 357
            |:|:|.||..| |.|||||:.:|:.:||:.|.|:
Frog   319 VINVHHRSSATYHPMAPWVKRLFLEKLPKLLCMK 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	105/220 (48%)
		Neur_chan_memb	248..>359	CDD:280999	68/111 (61%)
		Neur_chan_memb	<683..760	CDD:280999
chrnb3	XP_002942943.1	LIC	2..451	CDD:273305	182/359 (51%)
		LGIC_ECD_nAChR_B3	56..234	CDD:349827	94/191 (49%)
		Cys-loop	155..169	CDD:349827	8/13 (62%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2037
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9533
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010