DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nAChRalpha3 and chrna5

DIOPT Version :9

Sequence 1:	NP_001285015.1	Gene:	nAChRalpha3 / 31767	FlyBaseID:	FBgn0015519	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	XP_002937929.1	Gene:	chrna5 / 100379824	XenbaseID:	XB-GENE-5755296	Length:	476	Species:	Xenopus tropicalis

Alignment Length:	365	Identity:	178/365 - (48%)
Similarity:	246/365 - (67%)	Gaps:	28/365 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WFQVTIDM------ILVLSFISSSTANPDAKRLYDDLL--SNYNKLVRPVVNVTDALTVRIKLKL 59
            |..:.:|:      |...|:|:.|     ..||:..|.  .:|.:.||||.::.|.:.|:..|.:
Frog    25 WLFLCLDILHGACGISEPSYIAKS-----EDRLFKYLFQQQDYQRWVRPVEHLNDTVKVKFGLAI 84

  Fly    60 SQLIDVNLKNQIMTTNLWVEQSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEV 124
            :||:||:.|||:||||:|::|.|.|.||:|:|.|:.|:..:.||||.||.||||||:||||.||.
Frog    85 TQLVDVDEKNQLMTTNVWLKQEWVDVKLRWDPNEFAGITSIRVPSDSIWIPDIVLYDNADGRFEG 149

  Fly   125 TLATKATLNYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGT 189
            :: |||.:.|.|.:.|.|||.|||||.|||.:||||.|.|.||||||||||.|||:
Frog   150 SV-TKAVVRYDGTINWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDI--------- 204

  Fly   190 NVVE-VGVDLSEFYTSVEWDILEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCM 253
             ::| ..||..:|:.:.||:|:.....:..:...||..||  ||::..::|..||||:.|||||:
Frog   205 -ILEDYHVDKRDFFDNGEWEIVNATGNKGNRTDGCCFYPY--ITYSFIIKRLPLFYTLFLIIPCI 266

  Fly   254 GISFLTILVFYLPSDSGEKVSLSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFS 318
            |:||||||||||||:.|||:||..|:|:|||||.|::.||||.:|.|:||:|::::||||..|.|
Frog   267 GLSFLTILVFYLPSNEGEKISLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLS 331

  Fly   319 ICVTVLVLNIHFRSPQTH-TMAPWVRTVFINQLPRFLVMR 357
            |.:||..:|||.||..|| .||||||.:|:::||:.|.||
Frog   332 IVLTVFAINIHNRSSATHNAMAPWVRKIFLHKLPKLLCMR 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nAChRalpha3	NP_001285015.1	Neur_chan_LBD	26..241	CDD:280998	100/217 (46%)
		Neur_chan_memb	248..>359	CDD:280999	68/111 (61%)
		Neur_chan_memb	<683..760	CDD:280999
chrna5	XP_002937929.1	LIC	19..453	CDD:273305	178/365 (49%)
chrna5	XP_002937929.1	LGIC_ECD_nAChR_A5	47..255	CDD:349819	101/225 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2037
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D188416at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010