DRSC/TRiP Functional Genomics Resources

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Protein Alignment nAChRalpha3 and chrnb5a

DIOPT Version :9

Sequence 1:NP_001285015.1 Gene:nAChRalpha3 / 31767 FlyBaseID:FBgn0015519 Length:795 Species:Drosophila melanogaster
Sequence 2:XP_009289434.1 Gene:chrnb5a / 100003503 ZFINID:ZDB-GENE-090312-169 Length:494 Species:Danio rerio


Alignment Length:760 Identity:233/760 - (30%)
Similarity:322/760 - (42%) Gaps:295/760 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 ISSSTANPDAKRLYDDLL--SNYNKLVRPVVNVTDALTVRIKLKLSQLIDVNLKNQIMTTNLWVE 79
            ::.|.|....:||.|.||  ..||||:||.||.:..:|:.||:.|:|||.||.:.||||||:|:.
Zfish    20 VARSLAADAEERLVDFLLGPERYNKLIRPAVNKSQQVTIGIKVSLAQLISVNEREQIMTTNVWLT 84

  Fly    80 QSWYDYKLKWEPKEYGGVEMLHVPSDHIWRPDIVLYNNADGNFEVTLATKATLNYTGRVEWRPPA 144
            |.|.||:|.|:|.||.|::.|.:||.|||.|||||||||||.:||:....|.::.||.:.|.|||
Zfish    85 QEWNDYRLVWDPNEYEGIKKLRIPSRHIWLPDIVLYNNADGVYEVSFYCNAVVSNTGDIFWLPPA 149

  Fly   145 IYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRHIDELNGTNVVEVGVDLSEFYTSVEWDI 209
            ||||:|.|:|..||||:|.|.:||.|||||..::||....:.         ....::..|.||||
Zfish   150 IYKSACAIEVRNFPFDQQNCTLKFRSWTYDRTELDLYLTSDF---------ASRDDYTPSGEWDI 205

  Fly   210 LEVPAVRNEKFYTCCDEPYLDITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPSDSGEKVS 274
            :.:|..|||..   .|..|||:|::..::||.||||:||||||:.|:.|.|||||||||.|||::
Zfish   206 VSLPGRRNEDL---SDPTYLDVTYDFVIKRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMT 267

  Fly   275 LSISILLSLTVFFLLLAEIIPPTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQTHTMA 339
            |.||:||:||||.||:::|:|||||.|||:||:::|||:|.||||..:|.|||:|.|||.||.|.
Zfish   268 LCISVLLALTVFLLLISKIVPPTSLAVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHRMP 332

  Fly   340 PWVRTVFINQLPRFLVMRRPLYPISEMIKSSRRLMVRTCNGLELRDQIPPLPPPVALSRMHHSPK 404
            .||:.||:::||.||:||||                   ....:|::.          |..|..|
Zfish   333 EWVKRVFLHKLPFFLLMRRP-------------------GRSNVRERF----------RRKHQRK 368

  Fly   405 TTSRSTSPHLQHRVQTYNLMDECGMGMGGGASTITGHLSSLYPPTMSTANQQTSTTSSLIDAQYH 469
            :.|..|.                |:.:.|                               |:.: 
Zfish   369 SFSSDTK----------------GLRLDG-------------------------------DSYF- 385

  Fly   470 NQYQQTGGSLLDHPLTPTKFRQMTSTSSQTGQNGSGNGNGNGGYGGHGQSGGHHLYRQQSSCSAN 534
                     |.|.|                       |...|.:                    .
Zfish   386 ---------LSDDP-----------------------GRVCGAW--------------------R 398

  Fly   535 FSPLPQHAHQAHASTTTSDLGMANPNVIKSTTTVNSVATASTLADSCCSGTIQIHQGMGAGAACQ 599
            ...||                                                           :
Zfish   399 VGDLP-----------------------------------------------------------E 404

  Fly   600 SSELLHHQQLHHQQMHHQQQQQQQQQHHHHQRPTTSAAAAAAAAAAGGPSTSAAAAAAAAAAAAG 664
            .||.....::.|.                                                    
Zfish   405 GSEFRQRVKVRHD---------------------------------------------------- 417

  Fly   665 TPPPPPPPAGVCDILPACQREGGPHCCSGRGNVRQRWHTCPELHKAMDGVTYIADQTRKEEESTR 729
                                                    |::.:|::||.:||:..:.|::...
Zfish   418 ----------------------------------------PDVDEAIEGVRFIAEHMKIEDDDEG 442

  Fly   730 VKEDWKYVAMVLDRLFLWIFTIAVVVGTAGIILQAPTLYDTRMPI 774
            :.|||||||||:||||||||.:..||||.|:.:| |.......|:
Zfish   443 IIEDWKYVAMVIDRLFLWIFILVCVVGTLGLFVQ-PLFQSYNTPV 486

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nAChRalpha3NP_001285015.1 Neur_chan_LBD 26..241 CDD:280998 102/216 (47%)
Neur_chan_memb 248..>359 CDD:280999 70/110 (64%)
Neur_chan_memb <683..760 CDD:280999 28/76 (37%)
chrnb5aXP_009289434.1 Neur_chan_LBD 20..474 CDD:332142 230/745 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D188416at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm24622
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.920

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