DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1632 and FZD9

DIOPT Version :9

Sequence 1:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster
Sequence 2:	NP_003499.1	Gene:	FZD9 / 8326	HGNCID:	4047	Length:	591	Species:	Homo sapiens

Alignment Length:	332	Identity:	74/332 - (22%)
Similarity:	115/332 - (34%)	Gaps:	92/332 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   385 CSPLELSYCRQVGYNITTYPNLLGHASYEQLAEDVIVFRELVDGECHREAYDFVCRLLQPPCDTH 449
            |..:|:..||.:|||:|..||||||.|..:.|.::..|..||...||.....|:|.|..|.|
Human    39 CQAVEIPMCRGIGYNLTRMPNLLGHTSQGEAAAELAEFAPLVQYGCHSHLRFFLCSLYAPMC--- 100

  Fly   450 GSDLQPTPGQICREYCESFMAGCGGRLPQ---RFRQFFDCERFPESTGTQS-CHQKPHCVSDMQS 510
             :|...||...||..||.....|...:.|   .:....||.|.|......: |.:.|...:...:
Human   101 -TDQVSTPIPACRPMCEQARLRCAPIMEQFNFGWPDSLDCARLPTRNDPHALCMEAPENATAGPA 164

  Fly   511 NVQ--------SPRLCDGYADC-PDLSDERSCAFCSPNAL-YCGRGRACVPRKARCDGKADCPDG 565
            ...        :||......|. |......:|.  :|... |..:.|:|.||         |..|
Human   165 EPHKGLGMLPVAPRPARPPGDLGPGAGGSGTCE--NPEKFQYVEKSRSCAPR---------CGPG 218

  Fly   566 AD------EKD------------CL--SIAPLAADLLQP-------EPLVPYLS---RFHSAGYA 600
            .:      :||            |.  :...:...||:|       .|:: :||   ..:|..:.
Human   219 VEVFWSRRDKDFALVWMAVWSALCFFSTAFTVLTFLLEPHRFQYPERPII-FLSMCYNVYSLAFL 282

  Fly   601 VFSEKGVVGKLCAEGLEGDAKLVVRQTVSESLC------------------------------KS 635
            :.:..|.....|.:  |..|..|:::.:..:.|                              |.
Human   283 IRAVAGAQSVACDQ--EAGALYVIQEGLENTGCTLVFLLLYYFGMASSLWWVVLTLTWFLAAGKK 345

  Fly   636 LGYESVE 642
            .|:|::|
Human   346 WGHEAIE 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1632	NP_001245577.1	SEA	232..327	CDD:279699
		CRD_FZ	384..502	CDD:143549	40/120 (33%)
		PRKCSH-like	<503..>582	CDD:193472	16/108 (15%)
		LDLa	536..571	CDD:238060	10/53 (19%)
		Tryp_SPc	708..>809	CDD:304450
FZD9	NP_003499.1	TM helix 1	230..255	CDD:320164	1/24 (4%)
		TM helix 2	264..285	CDD:320164	4/21 (19%)
		TM helix 3	314..340	CDD:320164	0/25 (0%)
		TM helix 4	357..373	CDD:320164
		TM helix 5	395..425	CDD:320164
		TM helix 6	444..471	CDD:320164
		TM helix 7	503..528	CDD:320164
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	532..537
		Required for CTNNB1 accumulation and TCF transcription factor activity. /evidence=ECO:0000250\|UniProtKB:Q8K4C8	554..591
		CRD_FZ	35..161	CDD:321937	41/125 (33%)
		Required for Wnt-activated receptor activity. /evidence=ECO:0000250\|UniProtKB:Q8K4C8	58..172		33/117 (28%)
		7tmF_FZD9	221..542	CDD:320164	20/135 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900