DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG1632 and FZD8

DIOPT Version :9

Sequence 1:NP_001245577.1 Gene:CG1632 / 31763 FlyBaseID:FBgn0030027 Length:1056 Species:Drosophila melanogaster
Sequence 2:NP_114072.1 Gene:FZD8 / 8325 HGNCID:4046 Length:694 Species:Homo sapiens


Alignment Length:246 Identity:61/246 - (24%)
Similarity:85/246 - (34%) Gaps:75/246 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   385 CSPLELSYCRQVGYNITTYPNLLGHASYEQLAEDVIVFRELVDGECHREAYDFVCRLLQPPC-DT 448
            |..:.:..|:.:|||.|..||...|.:.::...:|..|..||:.:|..:...|:|.:..|.| :.
Human    35 CQEITVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLED 99

  Fly   449 HGSDLQPTPGQICREYCESFMAGC-------GGRLPQRFRQFFDCERFPESTGTQSCHQKPHCVS 506
            :...|.|     ||..||...|||       |...|.|.|    |:|.||               
Human   100 YKKPLPP-----CRSVCERAKAGCAPLMRQYGFAWPDRMR----CDRLPE--------------- 140

  Fly   507 DMQSNVQSPRLCDGYADCPDLSDERSCAFCSPNAL------------------------YCGRGR 547
              |.|..:  ||..|    :.:|..:.|...|..|                        :.|.||
Human   141 --QGNPDT--LCMDY----NRTDLTTAAPSPPRRLPPPPPGEQPPSGSGHGRPPGARPPHRGGGR 197

  Fly   548 ------ACVP--RKARCDGKADCPDGAD---EKDCLSIAPLAADLLQPEPL 587
                  |..|  |.....|||..|.|..   |..|...||:.:...:..||
Human   198 GGGGGDAAAPPARGGGGGGKARPPGGGAAPCEPGCQCRAPMVSVSSERHPL 248

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1632NP_001245577.1 SEA 232..327 CDD:279699
CRD_FZ 384..502 CDD:143549 35/124 (28%)
PRKCSH-like <503..>582 CDD:193472 24/113 (21%)
LDLa 536..571 CDD:238060 14/69 (20%)
Tryp_SPc 708..>809 CDD:304450
FZD8NP_114072.1 CRD_FZ8 31..155 CDD:143570 40/151 (26%)
Palmitate-binding groove. /evidence=ECO:0000250 71..78 3/6 (50%)
Wnt-binding. /evidence=ECO:0000250 95..100 1/4 (25%)
Wnt-binding. /evidence=ECO:0000250 147..152 3/8 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 155..226 15/70 (21%)
7tmF_FZD8 267..618 CDD:320378
TM helix 1 277..301 CDD:320378
TM helix 2 310..331 CDD:320378
TM helix 3 397..419 CDD:320378
TM helix 4 440..456 CDD:320378
TM helix 5 478..501 CDD:320378
TM helix 6 534..556 CDD:320378
TM helix 7 579..604 CDD:320378
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 608..613
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 648..668
PDZ-binding 692..694
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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