DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG1632 and FZD7

DIOPT Version :9

Sequence 1:NP_001245577.1 Gene:CG1632 / 31763 FlyBaseID:FBgn0030027 Length:1056 Species:Drosophila melanogaster
Sequence 2:NP_003498.1 Gene:FZD7 / 8324 HGNCID:4045 Length:574 Species:Homo sapiens


Alignment Length:322 Identity:79/322 - (24%)
Similarity:109/322 - (33%) Gaps:101/322 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   385 CSPLELSYCRQVGYNITTYPNLLGHASYEQLAEDVIVFRELVDGECHREAYDFVCRLLQPPCDTH 449
            |.|:.:..|..:.||.|..||||||.:.|....:|..|..||..:|..|...|:|.:..|.|...
Human    49 CQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVL 113

  Fly   450 GSDLQPTPGQICREYCESFMAGC-------GGRLPQRFRQFFDCERFPESTGTQSCHQKPHCVSD 507
            ...:.|     ||..||....||       |.:.|:|.|    ||.||.....:.|         
Human   114 DQAIPP-----CRSLCERARQGCEALMNKFGFQWPERLR----CENFPVHGAGEIC--------- 160

  Fly   508 MQSNVQSPRLCDG----------YADCPDLSDERSCAFCSPNALYCGRGR-----ACVPRKARCD 557
            :..|..     ||          |...|.|.|....|.  |.....||||     :| ||:.:..
Human   161 VGQNTS-----DGSGGPGGGPTAYPTAPYLPDLPFTAL--PPGASDGRGRPAFPFSC-PRQLKVP 217

  Fly   558 --------GKADC-----PDGAD------EKD---------------CLS----IAPLAADLLQ- 583
                    |:.||     |..|:      |::               |.|    :.....|:.: 
Human   218 PYLGYRFLGERDCGAPCEPGRANGLMYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRF 282

  Fly   584 --PEPLVPYLSR-------FHSAGYAVFSEKGVVGKLCAEGLEGDAKLVVRQTVSESLCKSL 636
              ||..:.:||.       .|.||: :..::.|    |.|....|....|.|...:..|..|
Human   283 SYPERPIIFLSGCYFMVAVAHVAGF-LLEDRAV----CVERFSDDGYRTVAQGTKKEGCTIL 339

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1632NP_001245577.1 SEA 232..327 CDD:279699
CRD_FZ 384..502 CDD:143549 39/123 (32%)
PRKCSH-like <503..>582 CDD:193472 25/131 (19%)
LDLa 536..571 CDD:238060 14/73 (19%)
Tryp_SPc 708..>809 CDD:304450
FZD7NP_003498.1 CRD_FZ7 45..169 CDD:143575 41/142 (29%)
7tmF_FZD7 243..573 CDD:320374 19/102 (19%)
TM helix 1 253..277 CDD:320374 2/23 (9%)
TM helix 2 286..307 CDD:320374 5/20 (25%)
TM helix 3 337..359 CDD:320374 1/3 (33%)
TM helix 4 380..396 CDD:320374
TM helix 5 418..441 CDD:320374
TM helix 6 472..494 CDD:320374
TM helix 7 523..548 CDD:320374
Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250 552..557
PDZ-binding 572..574
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3577
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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