DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1632 and FZD6

DIOPT Version :9

Sequence 1:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster
Sequence 2:	NP_001158087.1	Gene:	FZD6 / 8323	HGNCID:	4044	Length:	706	Species:	Homo sapiens

Alignment Length:	286	Identity:	64/286 - (22%)
Similarity:	101/286 - (35%)	Gaps:	78/286 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   385 CSPLELSYCRQVGYNITTYPNLLGHASYEQLAEDVIVFRELVDGECHREAYDFVCRLLQPPCDTH 449
            |.|:.:..|.::.||:|.:|||:||......|.::..|..|.:.||......|:|:...|.|...
Human    24 CEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLPLANLECSPNIETFLCKAFVPTCIEQ 88

  Fly   450 GSDLQPTPGQICREYCESFMAGC-------GGRLPQRFRQFFDCERFPESTGTQSCHQKPHCVSD 507
            ...:.|     ||:.||...:.|       |.|.|:.    .:|:|.      |.|.:......|
Human    89 IHVVPP-----CRKLCEKVYSDCKKLIDTFGIRWPEE----LECDRL------QYCDETVPVTFD 138

  Fly   508 MQSNVQSPRLCDGYADCPDLSDERSCAFCSPNALYCGRGRA--------CVPRKARCDGKADCPD 564
            ..:....|:......       :|...|..|..|....|:.        |.|         .||:
Human   139 PHTEFLGPQKKTEQV-------QRDIGFWCPRHLKTSGGQGYKFLGIDQCAP---------PCPN 187

  Fly   565 ---GADEKD-------CLSIAPLAADLL-------------QPE-PLVPYLSRFHSAGYAVFSEK 605
               .:||.:       .:||..|.|.|.             .|| |::     ::|..|::.|..
Human   188 MYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPERPII-----YYSVCYSIVSLM 247

  Fly   606 GVVGKLCAEGL---EGDAKLVVRQTV 628
            ..:|.|..:..   :.|.||.:..||
Human   248 YFIGFLLGDSTACNKADEKLELGDTV 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1632	NP_001245577.1	SEA	232..327	CDD:279699
		CRD_FZ	384..502	CDD:143549	33/123 (27%)
		PRKCSH-like	<503..>582	CDD:193472	17/96 (18%)
		LDLa	536..571	CDD:238060	9/52 (17%)
		Tryp_SPc	708..>809	CDD:304450
FZD6	NP_001158087.1	CRD_FZ6	20..146	CDD:143559	34/136 (25%)
		Frizzled	189..507	CDD:279827	20/90 (22%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	498..503
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	588..706
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810