DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1632 and FZD3

DIOPT Version :9

Sequence 1:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster
Sequence 2:	NP_059108.1	Gene:	FZD3 / 7976	HGNCID:	4041	Length:	666	Species:	Homo sapiens

Alignment Length:	228	Identity:	57/228 - (25%)
Similarity:	89/228 - (39%)	Gaps:	61/228 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   364 LGGHDETTEPVVTTTPAPPRRCSPLELSYCRQVGYNITTYPNLLGHASYEQLAEDVIVFRELVDG 428
            :|||...:             |.|:.|..|:.:.||.|..||||.|...:..|..:..|..:|:.
Human    20 IGGHSLFS-------------CEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNL 71

  Fly   429 ECHREAYDFVCRLLQPPCDTHGSDLQPTPGQICREYCESFMAGCGGRLPQRF----RQFFDCERF 489
            :|.|:...|:|.|..|.|..:|....|     ||..|:...:.| .:|.:.|    .:..:|.||
Human    72 DCSRDFRPFLCALYAPICMEYGRVTLP-----CRRLCQRAYSEC-SKLMEMFGVPWPEDMECSRF 130

  Fly   490 PESTGTQSCHQKPHCVSDMQSNVQSPRLCDGYADCPDLSDERSCAFCSPNALYCGRGRACVPRKA 554
            |:      | .:|:           |||.|     .:|:.|.:..  :|.|:....|..| ||:.
Human   131 PD------C-DEPY-----------PRLVD-----LNLAGEPTEG--APVAVQRDYGFWC-PREL 169

  Fly   555 RCDG------------KADCPDGADEKDCLSIA 575
            :.|.            ...||:....::.||.|
Human   170 KIDPDLGYSFLHVRDCSPPCPNMYFRREELSFA 202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1632	NP_001245577.1	SEA	232..327	CDD:279699
		CRD_FZ	384..502	CDD:143549	35/121 (29%)
		PRKCSH-like	<503..>582	CDD:193472	18/85 (21%)
		LDLa	536..571	CDD:238060	9/46 (20%)
		Tryp_SPc	708..>809	CDD:304450
FZD3	NP_059108.1	CRD_FZ3	24..150	CDD:143558	42/167 (25%)
		7tmF_FZD3	192..512	CDD:320161	3/11 (27%)
		TM helix 1	201..226	CDD:320161	1/2 (50%)
		TM helix 2	235..256	CDD:320161
		TM helix 3	287..313	CDD:320161
		TM helix 4	330..352	CDD:320161
		TM helix 5	366..391	CDD:320161
		TM helix 6	419..444	CDD:320161
		TM helix 7	473..498	CDD:320161
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	502..507
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	538..666
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810