DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1632 and st14a

DIOPT Version :9

Sequence 1:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster
Sequence 2:	NP_001035441.2	Gene:	st14a / 678603	ZFINID:	ZDB-GENE-030131-6496	Length:	834	Species:	Danio rerio

Alignment Length:	1082	Identity:	200/1082 - (18%)
Similarity:	322/1082 - (29%)	Gaps:	472/1082 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 LSTD------------SDIRFTRRKLGDGQKCGCAVIAGFLIALLVAGIFVYVGYTYFRPEPLPD 230
            :|||            ||.:...:|.|.| |.|..|....|.|:|...|.:.|.:.:||.:....
Zfish    13 VSTDKDWDQAVTFLPASDHKKMEKKKGPG-KIGIIVGLVILAAVLALIIGLVVWHFHFRNDLKLQ 76

  Fly   231 RVFRGRFMVLNDKWSMELANQNSMRFQHKARDYRERINLTL-RRSDLREAYEGSEILALDGSEDN 294
            :::.|.|.:.|:.:.....|..|..||:.|.....::.|.. ..|.|.:.|..|.:.|.
Zfish    77 KIYTGSFRITNEAFVDAYENPQSPEFQNLADKVSTQLKLMYSESSQLSKYYVTSRVQAF------ 135

  Fly   295 NNIVVHFNMIFDPYAGLVSSGDLLALFHEEMTQPPQQRRHFANMTVDVASLSIKETTG------- 352
                              |.|.::|.:..|...|   ..|.|.:...|::||.|.::|
Zfish   136 ------------------SEGSVIAYYESEFAVP---AAHEAAVDQAVSNLSEKYSSGKARKVSE 179

  Fly   353 ----LIEEPIM-------------SSSPLGGH------DETTEPVVTTTPAPPR-------RCSP 387
                |:.:.::             ||:....|      |....|....:|.|..       |..|
Zfish   180 QQGSLVLDSVVSSALDKRLISKARSSTRYNKHTSRFVEDIIFSPGFPDSPYPSNTFVQWQLRGDP 244

  Fly   388 ---LELSYCRQVGYNITTYPNLLGHAS------YEQL-AEDVIVFRELVDGECHREAYDFV---- 438
               |:|::        .|: ||..:.|      |:.| |.|..:..|........:...|:
Zfish   245 DHVLKLTF--------DTF-NLEQNCSNDFLRVYDSLVALDKFIMAEKCGYYSPSDPLSFISSRN 300

  Fly   439 CRLLQPPCDTHGSDLQPTPG------QICREYCESFMAGCGG-----RLPQRFRQFFDCE----- 487
            ..|:....:..|:    .||      ||....|...|.|..|     ..|..:.....|:
Zfish   301 VMLVTLVTNEEGA----YPGFRARVSQIQAVTCGGRMIGNSGIFTSPNFPDYYPPNITCQWYIEV 361

  Fly   488 --------RFPE---STGTQSCH--------------QKPHCVSDMQSNVQSPRL---------- 517
                    :||:   |||:: ||              |:.:.:..:.||..:.|.
Zfish   362 PAGKFIKLKFPKIMVSTGSE-CHGDFVEVVGQSKLCGQQLNTIVTVNSNTATVRFVSDSSNVDRG 425

  Fly   518 -------------------------------CDGYADCPDLSDERSC-----------AFCSP-- 538
                                           |||:.||.|.|||::|           ..|.|
Zfish   426 FSATFEDYSPSDPCQDLFLCNNKRCVKPSMRCDGWNDCGDTSDEQNCQCDAKMIQCKNGLCKPMF 490

  Fly   539 -------------NALYCG--------RGRACVPRKARCDGKADCPDGADEKDCLSIAPLAADLL 582
                         :.|.||        :...|:..|.:||||.||.||:||:.|
Zfish   491 WRCDGVDDCGDSTDELNCGCRADQFKCKNDKCISEKQKCDGKDDCNDGSDEEGC----------- 544

  Fly   583 QPEPLVPYLSRFHSAGYAVFSEKGVVGKLCAEGLEGDAKLVVRQTVSESLCKSLGYESVEIFDVQ 647
                     :|..|...:.|        ||     |::|.:.:....   |           |.|
Zfish   545 ---------ARTDSCLVSTF--------LC-----GNSKCITKPNPE---C-----------DGQ 573

  Fly   648 NDTERLNDYVRVLDPHAPEISFIRTHCPRRQVLYVGCGE------LRCGVQSALFNAKQHLSLPK 706
            :|                                  ||:      ..||.::   ..|..:...:
Zfish   574 DD----------------------------------CGDNSDESNCNCGTKA---YKKSRIVGGQ 601

  Fly   707 MSAPGDWPWLVALFREDI-HVCDGTLITQDWVLTTEGCFQ-------GQPRATWMAIVGAVRLSA 763
            .:..|::||.|:|..::| |||.|::|.:.|::|...|.|       .|| .||...:|.  .|.
Zfish   602 DAFEGEFPWQVSLHIKNIAHVCGGSIINERWIVTAAHCVQDDVKIKYSQP-GTWEVFLGL--HSQ 663

  Fly   764 KAPWTQRRRIIGMI------KSPVEGSTAALVRLETPVSYSDHVRPICLPDALQRRLLQQPPAQR 822
            |...|..:|::..:      .:....:..||:.:|:||::||.:||:|||.|
Zfish   664 KDKLTATKRLLKQVIPHPYYNAYTYDNDIALMEMESPVTFSDTIRPVCLPTA------------- 715

  Fly   823 RSHVPVAERLEGQLVSQQRSRLSQENQQFFLIPSQEQQDSSTENQGDEDQDEQEDHFGGESAASY 887

Zfish   716 ----------------------------------------------------------------- 715

  Fly   888 MPKAEALHQELDGYPLPDHAPQVNYYSSSSTVTSSSTAARIATKAPILAAVPAAQEQIWTNCNTL 952
                      .|.:|                   :.|:..|:
Zfish   716 ----------TDTFP-------------------AGTSVFIS----------------------- 728

  Fly   953 GWSRQRDH------LQRVQLKMGDMAPCENVSIATVNS--MCMEATYQKYDCTQEEYSGAPVQCL 1009
            ||...|:.      ||:.::::.:...|..:....:.|  .|........|..|.: ||.|:.
Zfish   729 GWGATREGGSGATVLQKAEVRIINSTVCNQLMGGQITSRMTCAGVLSGGVDACQGD-SGGPLS-- 790

  Fly  1010 IPGTNQWALIGVSSWRIACGPTGVERPRMYDKIASNAAWIRE 1051
            .|...:..|.||.||...|...  .:|.:|..:....|||:|
Zfish   791 FPSGKRMFLAGVVSWGDGCARR--NKPGIYSNVPKFRAWIKE 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1632	NP_001245577.1	SEA	232..327	CDD:279699	18/95 (19%)
		CRD_FZ	384..502	CDD:143549	34/172 (20%)
		PRKCSH-like	<503..>582	CDD:193472	31/153 (20%)
		LDLa	536..571	CDD:238060	17/57 (30%)
		Tryp_SPc	708..>809	CDD:304450	36/114 (32%)
st14a	NP_001035441.2	SEA	77..168	CDD:279699	24/117 (21%)
		CUB	219..322	CDD:238001	21/115 (18%)
		CUB	329..431	CDD:238001	17/102 (17%)
		LDLa	443..472	CDD:238060	9/28 (32%)
		LDLa	474..508	CDD:238060	3/33 (9%)
		LDLa	510..544	CDD:238060	12/33 (36%)
		LDLa	550..585	CDD:238060	11/95 (12%)
		Tryp_SPc	596..828	CDD:214473	64/369 (17%)
		Tryp_SPc	597..831	CDD:238113	67/372 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576723
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840