DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1632 and ST14

DIOPT Version :9

Sequence 1:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster
Sequence 2:	NP_068813.1	Gene:	ST14 / 6768	HGNCID:	11344	Length:	855	Species:	Homo sapiens

Alignment Length:	1068	Identity:	195/1068 - (18%)
Similarity:	297/1068 - (27%)	Gaps:	492/1068 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 AVIAGFLIALLVAGIFV-YVGYTYFRPEPLPDRVFRGRFMVLNDKWSMELANQNSMRFQHKARDY 263
            ||:.|.|:.||..|..| ::.|...|.:    :||.|...:.|:.:.....|.||..|...|...
Human    60 AVLIGLLLVLLGIGFLVWHLQYRDVRVQ----KVFNGYMRITNENFVDAYENSNSTEFVSLASKV 120

  Fly   264 RERINLTLRRSDLREAYEGSEILALDGSEDNNNIVVHFNMIFDPYAGLVSSGDLLALFHEEMTQP 328
            ::.:.|         .|.|...|   |.....:.|..|           |.|.::|.:..|.:.|
Human   121 KDALKL---------LYSGVPFL---GPYHKESAVTAF-----------SEGSVIAYYWSEFSIP 162

  Fly   329 -------------------PQQRRHFANMTVDVASLSIKETTGLIEEPIMSSSPLGGHDETTEPV 374
                               |.:.|...:..| .:.::....:..::....:|...|.|....|.:
Human   163 QHLVEEAERVMAEERVVMLPPRARSLKSFVV-TSVVAFPTDSKTVQRTQDNSCSFGLHARGVELM 226

  Fly   375 VTTTPAPPRRCSPLELSYCRQVGYNITTYPNLLGHASYEQL----AEDV--IVFRELVDGECHRE 433
            ..|||                 |:..:.||   .||..:..    |:.|  :.||
Human   227 RFTTP-----------------GFPDSPYP---AHARCQWALRGDADSVLSLTFR---------- 261

  Fly   434 AYDFVCRLLQPPCDTHGSDLQPTPG-----------QICREYCESF------------------- 468
            ::|..      .||..||||.....           |:|..|..|:
Human   262 SFDLA------SCDERGSDLVTVYNTLSPMEPHALVQLCGTYPPSYNLTFHSSQNVLLITLITNT 320

  Fly   469 ----------------MAGCGGRLPQ----------------------------------RFRQF 483
                            |:.|||||.:                                  ||:.|
Human   321 ERRHPGFEATFFQLPRMSSCGGRLRKAQGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFF 385

  Fly   484 F---------DCER-FPESTGTQSCHQKPHCVSDMQSN--------------------------- 511
            :         .|.: :.|..|.:.|.::...|....||
Human   386 YLLEPGVPAGTCPKDYVEINGEKYCGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYDSS 450

  Fly   512 --------------VQSPRLCDGYADCPDLSDERSCA------------FCSP------------ 538
                          ::....|||:|||.|.|||.:|:            ||.|
Human   451 DPCPGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCG 515

  Fly   539 ------------NALYCGRGRACVPRKARCDGKADCPDGADEKDCLSIAPLAADLLQPEPLVPYL 591
                        ....|..|: |:.:..:|:||.||.||:||..|            |:..|...
Human   516 DNSDEQGCSCPAQTFRCSNGK-CLSKSQQCNGKDDCGDGSDEASC------------PKVNVVTC 567

  Fly   592 SRFHSAGYAVFSEKGVVGKLCAEGLEGDAKLVVRQTVSESLCKSLGYESVEIFDVQNDTERLNDY 656
            :: |:  |.           |..|                ||.|.|
Human   568 TK-HT--YR-----------CLNG----------------LCLSKG------------------- 583

  Fly   657 VRVLDPHAPEISFIRTHCPRRQVLYVGCGE--LRCGVQSALFNAKQHLSLPKMSAPGDWPWLVAL 719
                   .||       |..::....|..|  ..||::|  |..:..:.....:..|:|||.|:|
Human   584 -------NPE-------CDGKEDCSDGSDEKDCDCGLRS--FTRQARVVGGTDADEGEWPWQVSL 632

  Fly   720 FR-EDIHVCDGTLITQDWVLTTEGC------FQGQPRATWMAIVGAVRLSAK-APWTQRRRIIGM 776
            .. ...|:|..:||:.:|:::...|      |:......|.|.:|....|.: ||..|.||:..:
Human   633 HALGQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRI 697

  Fly   777 IKSPVEGS-----TAALVRLETPVSYSDHVRPICLPDALQRRLLQQPPAQRRSHVPVAERLEGQL 836
            |..|....     ..||:.||.|..||..|||||||||              |||
Human   698 ISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLPDA--------------SHV---------- 738

  Fly   837 VSQQRSRLSQENQQFFLIPSQEQQDSSTENQGDEDQDEQEDHFGGESAASYMPKAEALHQELDGY 901
                                                                            :
Human   739 ----------------------------------------------------------------F 739

  Fly   902 PLPDHAPQVNYYSSSSTVTSSSTAARIATKAPILAAVPAAQEQIWTNCNTLGWSRQRDH------ 960
            |                                      |.:.||..    ||...:..
Human   740 P--------------------------------------AGKAIWVT----GWGHTQYGGTGALI 762

  Fly   961 LQRVQLKMGDMAPCENV--SIATVNSMCMEATYQKYDCTQEEYSGAPVQCLIPGTNQWALIGVSS 1023
            ||:.::::.:...|||:  ...|...||:.......|..|.: ||.|:.. :....:....||.|
Human   763 LQKGEIRVINQTTCENLLPQQITPRMMCVGFLSGGVDSCQGD-SGGPLSS-VEADGRIFQAGVVS 825

  Fly  1024 WRIACGPTGVERPRMYDKIASNAAWIRE 1051
            |...|...  .:|.:|.::.....||:|
Human   826 WGDGCAQR--NKPGVYTRLPLFRDWIKE 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1632	NP_001245577.1	SEA	232..327	CDD:279699	20/94 (21%)
		CRD_FZ	384..502	CDD:143549	33/213 (15%)
		PRKCSH-like	<503..>582	CDD:193472	30/155 (19%)
		LDLa	536..571	CDD:238060	14/58 (24%)
		Tryp_SPc	708..>809	CDD:304450	38/113 (34%)
ST14	NP_068813.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		SEA	88..>171	CDD:307516	21/105 (20%)
		CUB	227..332	CDD:238001	23/140 (16%)
		CUB	340..444	CDD:238001	15/103 (15%)
		LDLa	454..486	CDD:238060	10/31 (32%)
		LDLa	488..523	CDD:238060	3/34 (9%)
		LDLa	525..559	CDD:238060	12/34 (35%)
		LDLa	567..602	CDD:238060	13/97 (13%)
		Tryp_SPc	615..852	CDD:238113	72/371 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910