DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1632 and SMO

DIOPT Version :9

Sequence 1:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster
Sequence 2:	NP_005622.1	Gene:	SMO / 6608	HGNCID:	11119	Length:	787	Species:	Homo sapiens

Alignment Length:	343	Identity:	72/343 - (20%)
Similarity:	107/343 - (31%)	Gaps:	118/343 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   515 PRLCDGYADCPDLSDERSCAFCS--PNALYCGRGRACVP-RKARC--------------DGKADC 562
            ||...|       |..||.|...  |...:|||...|.| |...|              .|.:|.
Human    41 PRSAGG-------SARRSAAVTGPPPPLSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDS 98

  Fly   563 PDGADEK----DCLSIAPLAADLLQPEPLVPYLSRFHSAGYAVFSEKGVVGKLCAEGLEGDAKLV 623
            .:.|..|    ..|..||....::||.....|:.:..:....:.|.     .|| :...|...:|
Human    99 QEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSR-----TLC-QATRGPCAIV 157

  Fly   624 VRQTVSESLCKSLGYESVEIFDVQNDTERLNDYVRVLDPHAP------------------EISFI 670
            .|:.         |:.               |::|......|                  |:..:
Human   158 ERER---------GWP---------------DFLRCTPDRFPEGCTNEVQNIKFNSSGQCEVPLV 198

  Fly   671 RTHCPRRQVLYV-GCGELRCGVQSALFNAKQHLSLPK-MSAPGDWPWLVALFREDIHVCDGTLIT 733
            ||..|:.....| ||| ::|  |:.||...:|..:.. ::|.|....|..||         ||.|
Human   199 RTDNPKSWYEDVEGCG-IQC--QNPLFTEAEHQDMHSYIAAFGAVTGLCTLF---------TLAT 251

  Fly   734 --QDW----------VLTTEGCFQGQPRATWMAIVGAVRLSAKAPWTQRRRII----GMIK--SP 780
              .||          :.....||          .||::...|:.....||.|:    |.::  .|
Human   252 FVADWRNSNRYPAVILFYVNACF----------FVGSIGWLAQFMDGARREIVCRADGTMRLGEP 306

  Fly   781 VEGSTAALVRLETPVSYS 798
            ....|.:.|.:...|.|:
Human   307 TSNETLSCVIIFVIVYYA 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1632	NP_001245577.1	SEA	232..327	CDD:279699
		CRD_FZ	384..502	CDD:143549
		PRKCSH-like	<503..>582	CDD:193472	22/87 (25%)
		LDLa	536..571	CDD:238060	12/55 (22%)
		Tryp_SPc	708..>809	CDD:304450	24/109 (22%)
SMO	NP_005622.1	CRD_SMO	66..196	CDD:143560	26/159 (16%)
SMO	NP_005622.1	Frizzled	221..550	CDD:279827	27/123 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900