DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1632 and Fzd4

DIOPT Version :9

Sequence 1:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster
Sequence 2:	NP_072145.1	Gene:	Fzd4 / 64558	RGDID:	71017	Length:	538	Species:	Rattus norvegicus

Alignment Length:	155	Identity:	39/155 - (25%)
Similarity:	65/155 - (41%)	Gaps:	21/155 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   353 LIEEPIMSSSPLGGHDETTEPVVTTTPAPPRRCSPLELSYCRQVGYNITTYPNLLGHASYEQLAE 417
            |::..::....||..||           ..|||.|:.::.|:.:|||:|..|||:||........
  Rat    25 LLQLLLLQRPALGFGDE-----------EERRCDPIRIAMCQNLGYNVTKMPNLVGHELQTDAEL 78

  Fly   418 DVIVFRELVDGECHREAYDFVCRLLQPPCDTHGSDLQPTP-GQIC---REYCESFMAGCGGRLPQ 478
            .:..|..|:...|..:...|:|.:..|.| |...::...| |.:|   :..||..:...|...|.
  Rat    79 QLTTFTPLIQYGCSSQLQFFLCSVYVPMC-TEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPD 142

  Fly   479 RFRQFFDCERF-PESTGTQSCHQKP 502
            .    .:|.:| |::.....|.:.|
  Rat   143 S----LNCSKFPPQNDHNHMCMEGP 163

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1632	NP_001245577.1	SEA	232..327	CDD:279699
		CRD_FZ	384..502	CDD:143549	32/122 (26%)
		PRKCSH-like	<503..>582	CDD:193472	39/155 (25%)
		LDLa	536..571	CDD:238060
		Tryp_SPc	708..>809	CDD:304450
Fzd4	NP_072145.1	CRD_FZ4	43..168	CDD:143557	34/126 (27%)
		Frizzled	211..510	CDD:279827
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	500..505
		PDZ-binding	536..538
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900