DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1632 and tmprss5

DIOPT Version :9

Sequence 1:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster
Sequence 2:	XP_009289870.1	Gene:	tmprss5 / 569688	ZFINID:	ZDB-GENE-131121-184	Length:	551	Species:	Danio rerio

Alignment Length:	764	Identity:	156/764 - (20%)
Similarity:	238/764 - (31%)	Gaps:	294/764 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   364 LGGHDETTEPVVTTTPAPPRRCSPL--ELSYCRQVGYNITTYPNLLGHASYEQLAEDVIVFRELV 426
            ||.||...:|:..||.:   ..:||  .||.| :|........|.|..|..|.|..|
Zfish     9 LGSHDRPHDPLGKTTGS---FFAPLLTSLSLC-EVKIQRCIQLNGLTAAGVEHLCCD-------- 61

  Fly   427 DGECHREAYDFVCRLLQPPCDTHGSDLQPTPGQICREYCESFMAGCGGRLPQRFRQFFDCERFPE 491
            .|:..||:         ..|    |...|.|...........:|....  |...||.|    .||
Zfish    62 GGKLMRES---------SSC----SQEIPNPNNESMSLSRDAVAVIEN--PVVVRQSF----HPE 107

  Fly   492 STGT---QSCHQKPHCVSDMQ------SNVQSPRLCDGYADCPDLSDERSCAFCSPNALYCGRGR 547
            |...   :|......|:.::|      ..|.|.:|...:|           |.|    :.|..|.
Zfish   108 SLQVDMLESDQNNHRCLRELQFLHPVSGKVSSRKLVRVFA-----------ALC----VLCLLGG 157

  Fly   548 ACV-----------PRKARCDGKADCPDGADEKDCLSIAPLAADLLQPEPLVPYLSRFHSAGYAV 601
            ..|           |..::.....     .|.|| .|...:..|:...:|
Zfish   158 VVVGVWFIVKFLLKPNLSQSPASL-----GDTKD-TSFCNVTEDISVTDP--------------- 201

  Fly   602 FSEKGVVGKLCAEGLEGDAKLVVRQT------------VSESLCKSLGY------ESVEIFDV-Q 647
               :.|..::.||....:.:|...||            :...:|:.|||      :.|.:.|: .
Zfish   202 ---RKVFYRISAENSLLEIQLEKLQTWLPVCFERWNSSLGTLVCRQLGYLRLSKHKGVNLTDIGP 263

  Fly   648 NDTERLNDYVRVLDPHAPEISFI---RTHCPRRQVLYVGCGELRCGVQSALFNAKQHLSLPKM-- 707
            |.|:   .:|::...:...:..:   |..|...:|:.:.|.|  ||.::         .||::
Zfish   264 NYTD---GFVQITSEYQSNLESLWRFRGSCSTGKVIALKCFE--CGTRA---------KLPRIIG 314

  Fly   708 ---SAPGDWPWLVALFREDIHVCDGTLITQDWVLTTEGCFQGQ--PRA-TWMAIVGAVRLS-AKA 765
               :|.|.|||.|:|:..:.|:|.|::||..|::|...|....  |:. :|:...|.:..: ||.
Zfish   315 GVEAALGRWPWQVSLYYNNRHICGGSIITNQWIVTAAHCVHNYRLPQVPSWVVYAGIITSNLAKL 379

  Fly   766 PWTQRRRIIGMIKSP-----VEGSTAALVRLETPVSYSDHVRPICLPDALQRRLLQQPPAQRRSH 825
            ...|...:..:|.:.     ...:..|||:|:||:::||.:||:|||
Zfish   380 AQYQGFAVERIIYNKNYNHRTHDNDIALVKLKTPLNFSDTIRPVCLP------------------ 426

  Fly   826 VPVAERLEGQLVSQQRSRLSQENQQFFLIPSQEQQDSSTENQGDEDQDEQEDHFGGESAASYMPK 890
                                                             |.||
Zfish   427 -------------------------------------------------QYDH------------ 430

  Fly   891 AEALHQELDGYPLPDHAPQVNYYSSSSTVTSSSTAARIATKAPILAAVPAAQEQIWTNCNTLGW- 954
                  :|.|                                             .|.|...||
Zfish   431 ------DLPG---------------------------------------------GTQCWISGWG 444

  Fly   955 -SRQRDHLQRVQLKMGDMAPCENVSIATVNSMCM---EATYQ---------KYDCTQEEYSGAPV 1006
             ::..|.|....||   .||...:|....||.||   |.|.:         |.|..|.: ||.|:
Zfish   445 YTQPDDVLIPEVLK---EAPVPLISTKKCNSSCMYNGEITSRMLCAGYSEGKVDACQGD-SGGPL 505

  Fly  1007 QCLIPGTNQWALIGVSSWRIACGPTGVERPRMYDKIASNAAWIRETISA 1055
            .|  ...|.|.|:||.||...|...  ..|.:|.|:|....||.:.|.:
Zfish   506 VC--QDENVWRLVGVVSWGTGCAEP--NHPGVYSKVAEFLGWIYDIIES 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1632	NP_001245577.1	SEA	232..327	CDD:279699
		CRD_FZ	384..502	CDD:143549	28/122 (23%)
		PRKCSH-like	<503..>582	CDD:193472	17/95 (18%)
		LDLa	536..571	CDD:238060	7/45 (16%)
		Tryp_SPc	708..>809	CDD:304450	35/109 (32%)
tmprss5	XP_009289870.1	SRCR_2	211..306	CDD:292133	20/99 (20%)
		Tryp_SPc	311..544	CDD:214473	76/370 (21%)
		Tryp_SPc	312..547	CDD:238113	78/372 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576758
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930