DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1632 and lrp2a

DIOPT Version :9

Sequence 1:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster
Sequence 2:	NP_001181916.1	Gene:	lrp2a / 568184	ZFINID:	ZDB-GENE-050119-2	Length:	4673	Species:	Danio rerio

Alignment Length:	699	Identity:	146/699 - (20%)
Similarity:	208/699 - (29%)	Gaps:	247/699 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   438 VCRLLQPPCDTHGSDLQPTPGQICREYCES--FMAGCGGRLP--QRFRQFFDCERFPESTGTQSC 498
            :|.|   .||..||.            |||  |..|.|..:|  ||.....||....:..|   |
Zfish    11 LCAL---QCDCQGSG------------CESGFFRCGTGRCIPVSQRCDGTNDCSDNSDEIG---C 57

  Fly   499 HQKP------HCVSDMQSNVQSPRLCDGYADCPDLSDERS-C--AFCSPNALYCGRGRACVPRKA 554
            .|..      .|:||.:. :....:||...||.|.||||. |  ..||.:...|..| ||:|...
Zfish    58 PQPTCESAQFQCLSDGEC-IPQHWVCDDEEDCEDGSDERQHCPGRTCSSSQFTCTNG-ACIPGGY 120

  Fly   555 RCDGKADCPDGADEKDCLSIAPLAADLLQPEPLVPYLSRFHSAGYAVFSEKGVVGKL--CAEGLE 617
            |||...||.|||||::|               ..|..|....|..|.|:......::  |.:|.:
Zfish   121 RCDRVPDCLDGADERNC---------------FYPECSELRCANGACFNRSQRCDQVLNCRDGSD 170

  Fly   618 GDAKLVVRQTVSESLCKS-----LGYESVEIFDVQNDTERLNDYVRVLDPHAPEISFIRTHC--P 675
             :|....|.:..:..|.:     .||    |.|..:|....:|               ..:|  |
Zfish   171 -EANCTQRCSSGQFQCSNGECIPRGY----ICDHDDDCGDRSD---------------EQNCTYP 215

  Fly   676 RRQVLYVGCGELRCGVQSALFNAKQHL----------SLPKMSAPGDWP----WLVALFREDIHV 726
            ..:..|..|...||..|..|.:.:...          ::.:...||:||    .:...|.   |:
Zfish   216 TCRGTYFTCPSGRCIHQVWLCDGEDDCEDNADEKGCDNVQQECYPGEWPCPSSGVCIPFD---HL 277

  Fly   727 CDGTLITQDWVLTTEGCFQGQPRATWMAIVGAVRLSAKAPWTQRRRIIGMIKSPVEGSTAALVRL 791
            ||||:...|....| ....|:..:.|.....:......|             || :|.|.|
Zfish   278 CDGTVHCPDGEDET-NITAGRNCSIWRCASLSCEHHCHA-------------SP-DGGTCA---- 323

  Fly   792 ETPVSYSDHVRPICLPDALQRRLLQQPPAQRRSHVPVAERLEGQLVSQQRSRLSQENQQFFLIPS 856
                         |            ||              |.:::...||           ..
Zfish   324 -------------C------------PP--------------GYVINTNDSR-----------SC 338

  Fly   857 QEQQDSSTENQGDEDQDEQEDHFGGESAASYMPKAEALHQELDGYPLPDH--------------- 906
            .:..|.|.....|:   ..||..|....:.           .|||.|..|
Zfish   339 MDYDDCSLWGMCDQ---LCEDRIGSHRCSC-----------RDGYILEQHRYCRANPSSGVPSLI 389

  Fly   907 --------APQVNYYSSSSTVTSSSTAARIATKAPILAAVPAAQEQIWTNC---NTLGWSRQRDH 960
                    ...|:.:.|.:.|.|.:..|.:......     ..|...||:.   ...........
Zfish   390 FSNGRDLLIADVHGHGSQTLVQSQNRGAAVGVDFHY-----QLQRVFWTDTIQNKVFSVDMDGSR 449

  Fly   961 LQRVQLKMGDMAPCENVSIATVNS--MCMEATYQKYDCTQEEYSGAPVQCLIPGTNQWALIG--- 1020
            || |.|.:....| ||:::..||:  ..:||:..:.|...           :.|:|:..||.
Zfish   450 LQ-VVLNVSVDYP-ENLAVDWVNNKLYVVEASVNRIDMVD-----------LDGSNRVTLIAEHL 501

  Fly  1021 ----------------VSSWRIACGPTGVERPRM-----YDKIASNAAW 1048
                            .|.|....|..|:||..|     |..|.:...|
Zfish   502 GNPRGLALDPTVGYLFFSDWDTLNGEPGLERAYMDGTNRYGIIRTKLGW 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1632	NP_001245577.1	SEA	232..327	CDD:279699
		CRD_FZ	384..502	CDD:143549	20/67 (30%)
		PRKCSH-like	<503..>582	CDD:193472	31/81 (38%)
		LDLa	536..571	CDD:238060	17/34 (50%)
		Tryp_SPc	708..>809	CDD:304450	21/104 (20%)
lrp2a	NP_001181916.1	LDLa	23..57	CDD:238060	12/36 (33%)
		Ldl_recept_a	61..96	CDD:278486	11/35 (31%)
		LDLa	103..137	CDD:238060	17/34 (50%)
		LDLa	143..174	CDD:238060	7/31 (23%)
		LDLa	178..212	CDD:238060	7/52 (13%)
		LDLa	217..251	CDD:238060	6/33 (18%)
		LDLa	258..292	CDD:238060	12/37 (32%)
		NHL	<429..610	CDD:302697	28/135 (21%)
		NHL repeat	461..496	CDD:271320	10/46 (22%)
		LY	495..540	CDD:214531	9/44 (20%)
		LY	543..583	CDD:214531	2/8 (25%)
		NHL repeat	550..591	CDD:271320	1/1 (100%)
		FXa_inhibition	655..696	CDD:291342
		LY	768..804	CDD:214531
		Ldl_recept_b	830..870	CDD:278487
		LY	854..896	CDD:214531
		FXa_inhibition	973..1005	CDD:291342
		LDLa	1018..1052	CDD:238060
		LDLa	1059..1093	CDD:238060
		LDLa	1101..1135	CDD:238060
		LDLa	1141..1175	CDD:238060
		LDLa	1179..1214	CDD:238060
		LDLa	1222..1255	CDD:197566
		LDLa	1264..1298	CDD:238060
		LDLa	1304..1337	CDD:197566
		FXa_inhibition	1351..1386	CDD:291342
		EGF_CA	1388..1418	CDD:214542
		LY	1459..1498	CDD:214531
		LY	1500..1541	CDD:214531
		LY	1543..1585	CDD:214531
		LY	1589..1630	CDD:214531
		FXa_inhibition	1709..1740	CDD:291342
		NHL	<1799..1978	CDD:302697
		NHL repeat	1823..1866	CDD:271320
		NHL repeat	1872..1913	CDD:271320
		Ldl_recept_b	1883..1927	CDD:278487
		LY	1912..1953	CDD:214531
		NHL repeat	1920..1946	CDD:271320
		FXa_inhibition	2022..2058	CDD:291342
		NHL	<2125..2295	CDD:302697
		NHL repeat	2149..2186	CDD:271320
		LY	2182..2225	CDD:214531
		NHL repeat	2189..2226	CDD:271320
		LY	2228..2267	CDD:214531
		NHL repeat	2235..2276	CDD:271320
		FXa_inhibition	2346..2382	CDD:291342
		LY	2461..2500	CDD:214531
		Ldl_recept_b	2519..2559	CDD:278487
		LY	2545..2585	CDD:214531
		Ldl_recept_b	2603..2642	CDD:278487
		FXa_inhibition	2655..2691	CDD:291342
		LDLa	2759..2793	CDD:238060
		LDLa	2798..2835	CDD:238060
		LDLa	2838..2872	CDD:294076
		LDLa	2882..2913	CDD:238060
		LDLa	2923..2955	CDD:197566
		LDLa	2965..3002	CDD:197566
		LDLa	3011..3045	CDD:238060
		LDLa	3050..3083	CDD:238060
		LDLa	3093..3127	CDD:238060
		cEGF	3150..3173	CDD:289433
		vWFA	<3165..3206	CDD:294047
		LY	3237..3279	CDD:214531
		LY	3282..3321	CDD:214531
Ldl_recept_b	3350..3390	CDD:278487
LY	3376..3416	CDD:214531
LY	3417..3458	CDD:214531
FXa_inhibition	3486..>3514	CDD:291342
LDLa	3529..3561	CDD:238060
LDLa	3570..3602	CDD:238060
LDLa	3611..3643	CDD:238060
LDLa	3651..3683	CDD:197566
LDLa	3699..3731	CDD:238060
LDLa	3738..3771	CDD:238060
LDLa	3776..3810	CDD:238060
LDLa	3815..3849	CDD:238060
LDLa	3859..3891	CDD:238060
LDLa	3902..3932	CDD:197566
LDLa	3945..3979	CDD:238060
EGF_CA	4024..4055	CDD:214542
LY	4158..4193	CDD:214531
Ldl_recept_b	4214..4254	CDD:278487
LY	4238..4281	CDD:214531
FXa_inhibition	4356..>4377	CDD:291342
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910