DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1632 and fzd3a

DIOPT Version :9

Sequence 1:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster
Sequence 2:	XP_005160805.1	Gene:	fzd3a / 565921	ZFINID:	ZDB-GENE-990415-225	Length:	686	Species:	Danio rerio

Alignment Length:	259	Identity:	65/259 - (25%)
Similarity:	92/259 - (35%)	Gaps:	77/259 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   385 CSPLELSYCRQVGYNITTYPNLLGHASYEQLAEDVIVFRELVDGECHREAYDFVCRLLQPPCDTH 449
            |.|:.|..|:.:.||.|..||||.|...:..|..:..|..:|:.||..|...|:|.|..|.|..:
Zfish    30 CEPITLRMCQGLAYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLECSTEIRPFLCALYAPVCTEY 94

  Fly   450 GSDLQPTPGQICREYCESFMAGC-------GGRLPQRFRQFFDCERFPESTGTQSCHQK-PHCVS 506
            |....|     ||..|:...:.|       |...|..    .:|.||||      |.:. |..:.
Zfish    95 GRVTLP-----CRRLCQRAKSDCYKLMEMFGVSWPDE----MECSRFPE------CEESYPRAID 144

  Fly   507 DMQSNVQSPRLCDGYADCPDLSDERSCAFCSPNAL-------YCGRG-RACVPRKARCDGKADCP 563
            .:.|:       |...:.|. :.:|...|..|..|       |...| |.|.|         .||
Zfish   145 LLPSS-------DSTEESPS-AVQRDYGFWCPRELKIEPDLGYSFMGVRDCSP---------PCP 192

  Fly   564 DGADEKD----------CLSIAPLAADLL-------------QPE-PLVPYLSRFHSAGYAVFS 603
            :....||          .:||..|:|.|.             .|| |::     |::..|.:.|
Zfish   193 NMYFRKDELIFARYFIGVISIVCLSATLFTFLTFLIDVGRFRYPERPII-----FYAVCYMMVS 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1632	NP_001245577.1	SEA	232..327	CDD:279699
		CRD_FZ	384..502	CDD:143549	37/124 (30%)
		PRKCSH-like	<503..>582	CDD:193472	20/96 (21%)
		LDLa	536..571	CDD:238060	11/52 (21%)
		Tryp_SPc	708..>809	CDD:304450
fzd3a	XP_005160805.1	CRD_FZ3	26..152	CDD:143558	40/143 (28%)
fzd3a	XP_005160805.1	Frizzled	195..513	CDD:279827	13/62 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900