DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1632 and TMPRSS15

DIOPT Version :9

Sequence 1:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster
Sequence 2:	XP_011527956.1	Gene:	TMPRSS15 / 5651	HGNCID:	9490	Length:	1064	Species:	Homo sapiens

Alignment Length:	880	Identity:	177/880 - (20%)
Similarity:	278/880 - (31%)	Gaps:	372/880 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   243 KWSMELANQNSMR---FQHKARDYRERIN---LTLRRSDLREAYEGSEILALDGSEDNNNIVVHF 301
            |.|:.::|..:|.   || |..:|.:..|   :||                        |..|.|
Human   481 KLSINISNDQNMEKTVFQ-KEGNYGDNWNYGQVTL------------------------NETVKF 520

  Fly   302 NMIFDPYAGLVSSGDLLALFHEEMTQPPQQRRHFANMTVDVASLSIKETTGLIEEPIMSSSPLGG 366
            .:.|:.:...:.|                          |:|...|..|.|:....:.
Human   521 KVAFNAFKNKILS--------------------------DIALDDISLTYGICNGSLY------- 552

  Fly   367 HDETTEPVVTTTPAP--PRRC-SPLELSYCRQVGYNITTYPNLLGHASYEQLA------------ 416
                .||.:..||.|  |..| .|.|| :.....::.|.:||     ||..||
Human   553 ----PEPTLVPTPPPELPTDCGGPFEL-WEPNTTFSSTNFPN-----SYPNLAFCVWILNAQKGK 607

  Fly   417 --------------EDVIVFRELVDGECHREAYDFVCRLLQPPCDTHGSDLQPTPGQICREYCES 467
                          .||:   |:.|||   ||...:..:...|...  .|:..|..::......:
Human   608 NIQLHFQEFDLENINDVV---EIRDGE---EADSLLLAVYTGPGPV--KDVFSTTNRMTVLLITN 664

  Fly   468 FMAGCGGRLPQRFRQFFDCERFPESTGTQSCHQKPHCVSDMQSNVQSPRLCDGYADCPDLSDERS 532
            .:...||     |:..|       :||......:|
Human   665 DVLARGG-----FKANF-------TTGYHLGIPEP------------------------------ 687

  Fly   533 CAFCSPNALYCGRGRACVPRKARCDGKADCPDGADEKDCLSIAPLAADLLQPEPLVPYLSRF--- 594
               |..:...|..|. |||....|||...|.||:||.||:                    ||
Human   688 ---CKADHFQCKNGE-CVPLVNLCDGHLHCEDGSDEADCV--------------------RFFNG 728

  Fly   595 --HSAGYAVFSEKGVVGKLCAEGLEGDAKLVVRQTVSESLCKSLGY----ESVEIFDVQNDT-ER 652
              ::.|...|..:.:....|||..        ...:|..:|:.||.    .|..||...... .:
Human   729 TTNNNGLVRFRIQSIWHTACAENW--------TTQISNDVCQLLGLGSGNSSKPIFPTDGGPFVK 785

  Fly   653 LNDYVRVLDPHAPEISFIRT---HCPRRQVLYVGCGELRCGVQSAL----------FNAKQHLSL 704
            ||.        ||:...|.|   .|.:..::.:.|....||.:.|.          .|||:
Human   786 LNT--------APDGHLILTPSQQCLQDSLIRLQCNHKSCGKKLAAQDITPKIVGGSNAKE---- 838

  Fly   705 PKMSAPGDWPWLVALFREDIHVCDGTLITQDWVLTTEGCFQG---QPRATWMAIVGA-VRLSAKA 765
                  |.|||:|.|:.....:|..:|::.||:::...|..|   :| :.|.||:|. ::.:..:
Human   839 ------GAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRNLEP-SKWTAILGLHMKSNLTS 896

  Fly   766 PWTQRRRIIGMIKSP-----VEGSTAALVRLETPVSYSDHVRPICLPDALQRRLLQQPPAQRRSH 825
            |.|..|.|..::.:|     .:.:..|::.||..|:|:|:::|||||
Human   897 PQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLP------------------ 943

  Fly   826 VPVAERLEGQLVSQQRSRLSQENQQFFLIPSQEQQDSSTENQGDEDQDEQEDHFGGESAASYMPK 890
                                :|||.|   |.                        |.:.:
Human   944 --------------------EENQVF---PP------------------------GRNCS----- 956

  Fly   891 AEALHQELDGYPLPDHAPQVNYYSSSSTVTSSSTAARIATKA--PILAAVPAAQEQIWTNCNTLG 953
                   :.|:               .||....|.|.|..:|  |:|:.
Human   957 -------IAGW---------------GTVVYQGTTANILQEADVPLLSN---------------- 983

  Fly   954 WSRQRDHLQRVQLKMGDMAPCENVSIATVNSMCMEATYQK--YDCTQEEYSGAPVQCLIPGTNQW 1016
                    :|.|.:|    |..|:   |.|.:|  |.|::  .|..|.: ||.|:.|  ...|:|
Human   984 --------ERCQQQM----PEYNI---TENMIC--AGYEEGGIDSCQGD-SGGPLMC--QENNRW 1028

  Fly  1017 ALIGVSSWRIACG-PTGVERPRMYDKIASNAAWIR 1050
            .|.||:|:...|. |   .||.:|.:::....||:
Human  1029 FLAGVTSFGYKCALP---NRPGVYARVSRFTEWIQ 1060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1632	NP_001245577.1	SEA	232..327	CDD:279699	16/89 (18%)
		CRD_FZ	384..502	CDD:143549	28/144 (19%)
		PRKCSH-like	<503..>582	CDD:193472	16/78 (21%)
		LDLa	536..571	CDD:238060	14/34 (41%)
		Tryp_SPc	708..>809	CDD:304450	33/109 (30%)
TMPRSS15	XP_011527956.1	SEA	53..195	CDD:214554
		LDLa	229..263	CDD:238060
		CUB	270..376	CDD:278839
		MAM	387..547	CDD:214533	21/116 (18%)
		MAM	392..547	CDD:99706	21/116 (18%)
		CUB	569..676	CDD:278839	25/125 (20%)
		LDLa	688..722	CDD:238060	14/34 (41%)
		SR	723..816	CDD:214555	22/128 (17%)
		Tryp_SPc	829..1059	CDD:214473	78/371 (21%)
		Tryp_SPc	830..1061	CDD:238113	80/373 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143825
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840