DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1632 and col18a1a

DIOPT Version :9

Sequence 1:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster
Sequence 2:	XP_021334395.1	Gene:	col18a1a / 564123	ZFINID:	ZDB-GENE-030516-3	Length:	1645	Species:	Danio rerio

Alignment Length:	608	Identity:	115/608 - (18%)
Similarity:	188/608 - (30%)	Gaps:	225/608 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   306 DPYAGLVSSGDLLALFHEEMTQ-------PPQQRRHFANMTVDVASLSIKETTGLIEEPIMSSSP 363
            |...|::.....|   |.::|:       .|...|....:.|...:::.|..        ::.|.
Zfish   113 DKIWGIIDDNSSL---HNQVTKVDQTDGLDPANSRFNEGVNVSFTNITAKNN--------VNESN 166

  Fly   364 LGGHDETT-----------------EPVVTTTPA--PPRRCSPLE--LSYCRQVGYNITTYPNLL 407
            ...|..||                 :.::.:.||  .|.||.|::  |.:|.:.|....:.||.|
Zfish   167 FAEHANTTLYSSEYAVSDNALTIESQFLIASMPASFEPLRCLPVDSGLPFCTRRGVESFSVPNFL 231

  Fly   408 GHASYEQLAEDVIVFRELVDGECHREAYDFVCRLLQPPCDTHGSDLQPTPGQICREYCESFMAGC 472
            ..:|.|::...:..:..|:...||.....|.|.||.|.|. |...|.|     ||..||.....|
Zfish   232 NQSSVEEVRMVLTEWAWLLRSGCHHSLEWFFCLLLTPRCG-HSGSLLP-----CRSSCEVLQDSC 290

  Fly   473 -----GGRLPQRFRQFFDCERFPESTGTQSCHQKPHCVSDMQSNVQSPRLCDGYADCPDLSDERS 532
                 .||||      .:|:..||         :.|               |||.
Zfish   291 WTLLDEGRLP------VECKSLPE---------EKH---------------DGYR---------- 315

  Fly   533 CAFCSPNALYCGRGRACVPRKARCDGKADCPDGADEKDCLSIAPL----AADLLQ------PEPL 587
                                                  |||::.|    ...|||      |..:
Zfish   316 --------------------------------------CLSVSNLKEESGVSLLQLIGDPPPNGV 342

  Fly   588 VPYLSRFHSAGYAVFSEKGVVGKLCAEGLEG----DAKLVVRQTVSESLCKSLGYESVEIFDVQN 648
            .....:.:|.|| ||.....||:..|..|..    |..|                    ||:::.
Zfish   343 SKVFDQANSPGY-VFGPSSNVGQSAAAHLPNPFYRDFSL--------------------IFNIKP 386

  Fly   649 DTERLNDYVRVLDPHAPEISFIRTHCPRRQVLYVG--CGELRCGVQSALF-----NAKQHLSLPK 706
            .:.:            |.:.|..|. |.:.::|||  ...:..|.||.:|     :::......:
Zfish   387 TSSK------------PGVIFSITD-PTQNIMYVGVKLSAVERGKQSIIFYYTEPDSQSSYEAAR 438

  Fly   707 MSAP---GDWP-WLVALFREDIHV---CDGTLITQDWVLTTE------------GCFQGQPRAT- 751
            .|..   ..|. :.:::..|.:.:   ||    :...|:..|            |.|.|.....
Zfish   439 FSVSSMLNIWTRFSISVLNEQVSLYFNCD----SDPQVVNFERSPDDMDMDAGAGVFVGHASGAD 499

  Fly   752 ---WMAIVGAVRLSAKAPWTQRR----------RIIGMIKSPVEGSTAALVRLETPVSYSDHVRP 803
               ::.::|.:|:|......:|.          ...|...:..:|...:.|:...|.|     ||
Zfish   500 PDKFLGVIGDLRVSRDPGAAERHCEEEEDDYATEASGDYGASGDGEQPSPVQPTPPSS-----RP 559

  Fly   804 ICLPDALQRRLLQQPPAQRRSHV 826
            |..|..:.|..:|:||...|..:
Zfish   560 IQRPPVISRDPIQRPPVISREPI 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1632	NP_001245577.1	SEA	232..327	CDD:279699	4/20 (20%)
		CRD_FZ	384..502	CDD:143549	35/124 (28%)
		PRKCSH-like	<503..>582	CDD:193472	8/82 (10%)
		LDLa	536..571	CDD:238060	0/34 (0%)
		Tryp_SPc	708..>809	CDD:304450	23/133 (17%)
col18a1a	XP_021334395.1	CRD_Collagen_XVIII	203..340	CDD:143564	47/220 (21%)
		LamG	327..516	CDD:328935	41/226 (18%)
		Collagen	816..860	CDD:189968
		Collagen	<937..980	CDD:189968
		Collagen	959..1055	CDD:189968
		Endostatin	1471..1639	CDD:310825
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900