DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1632 and zmp:0000001114

DIOPT Version :9

Sequence 1:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster
Sequence 2:	XP_685356.5	Gene:	zmp:0000001114 / 557248	ZFINID:	ZDB-GENE-140106-74	Length:	841	Species:	Danio rerio

Alignment Length:	1039	Identity:	191/1039 - (18%)
Similarity:	313/1039 - (30%)	Gaps:	391/1039 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 TRRKLGDGQKCGCAVIAGFLIALLVAGIFVYVGYTYF----RPEPLPDR-----------VFRGR 236
            :.:|....:|.|.|:  |.:|||||  :...||:..:    |.:.|.|:           |:.|:
Zfish    22 SNQKKASNRKTGIAI--GVIIALLV--VAAVVGFLVWLFVVRTKELEDQSTIEKHSSSTLVYSGQ 82

  Fly   237 FMVLNDKWSMELANQNSMRFQHKARDYRERINLTLRRSDLREAYEGSEILALDGSEDNNNIVVHF 301
            ..:|..:::....|..:.:||..|:|....:|.|..|..:...|....::.   :.....|..|:
Zfish    83 IRLLKPEFNPAYENPETPQFQQAAKDLETIMNDTFTRDPILSKYYTKSVIT---AFSEGTIAYHW 144

  Fly   302 NMIFDPYAGLVSSGDLLALFHEEMTQPPQQRRHFANMTVDVASLSIK--------------ETTG 352
                       |..|:..:..|.:.|..::|      .|:....||:              :.|.
Zfish   145 -----------SQFDVPEMDQEMVPQVSEER------VVEALRRSIRQEGRREGKVAVTATDITA 192

  Fly   353 LIEEPIMSSSPLGGH-------DETTEPVVTTTPAPPR------RC------------------- 385
            ...:|.|:..|...:       |.||:..  ::|..|:      ||
Zfish   193 STTDPRMARDPNSKNCFFSLTADPTTKEF--SSPGNPKSYPAYSRCQWQIRANKGSAIIVKFKTF 255

  Fly   386 -----------------SP-LELSYCRQVGYNITTYPNLLGHASYEQLAEDVIVFRELVDGECHR 432
                             || ...:..:|.|....|.|       .|.::...::...||..|..:
Zfish   256 NIEDDCYNDFVAIYDSLSPDRSRAITKQCGLRPPTNP-------LEVVSSGNLMLVNLVTDEVRK 313

  Fly   433 EAYDFVCRLLQ-PPCDTHGSDLQPTPGQICREYCESF---MAGC--------GGRLPQRFRQF-- 483
            ..:......:. .|....|..|..:.|:....|..||   ...|        |..:...|..|
Zfish   314 PGFRATYNAIPITPAGRCGQSLTDSTGEFTSPYFPSFYPPSVDCSWNIKVPEGKNIKIEFNMFRL 378

  Fly   484 -------FDCER-FPESTGTQSCHQKPHCVSDMQSNV---------------------------- 512
                   .:|.: :.|..|.:.|.:|...|...:|||
Zfish   379 KEPGVDPNNCNKDYIEVLGQKYCGEKSRLVISSKSNVLEVKFHSDESYTDKGFKLTYTAFDPVNP 443

  Fly   513 -------------QSPRLCDGYADCPDLSDERSCAFCSPNALYCGRGRACVPRKARCDGKADCPD 564
                         :..:||||:.||.|:|||::|. |:.:...|..| .|.|:...||...||.|
Zfish   444 CPGQFACSSGYCIRKEQLCDGWNDCQDMSDEKNCK-CNEDQFTCSNG-LCRPQFFVCDRANDCGD 506

  Fly   565 GADEKDCLSIAPLAADLLQPEPLVPYLSRFHSAGYAVFSEKGVVGKLCAEG-------------- 615
            .:|||||                                :.|.....|..|
Zfish   507 NSDEKDC--------------------------------DCGRAQVRCGNGACIMQDFVCDGKND 539

  Fly   616 -LEGDAKLVVRQTVSESLCKSLGYESVEIFDVQNDTERLNDYVRVLDPHAPEISFIRTHCPRRQV 679
             |:|..:  |....|..:|....::.       .:.:.:|.              :...|.|...
Zfish   540 CLDGSDE--VSCAASPGVCNDFSFKC-------KNKQCVNK--------------VNAECDREDD 581

  Fly   680 LYVGCGELRCGVQSALFNAKQHLSLPKMSAP-GDWPWLVAL-FREDIHVCDGTLITQDWVLTTEG 742
            ...|..|..|...:..:  |.:..:...:|. |:|||.|:| |:...|.|..::|:..|:|....
Zfish   582 CSDGSDEQGCDCGTRPY--KHNRIVGGQNADVGEWPWQVSLHFKTQGHACGASIISNKWLLCAAH 644

  Fly   743 CF-QGQP----RATWMAIVGAVRLSAKAPWTQRRRIIGMIKSP-----VEGSTAALVRLETPVSY 797
            || |..|    .::|:...|....:......|.|.:..:|..|     ......:|:.|..|:::
Zfish   645 CFIQPDPSYKMTSSWITYSGLRDQNTHDKSVQMRDLKTIITHPNYNDLTNDYDISLLELSQPLNF 709

  Fly   798 SDHVRPICLPDALQRRLLQQPPAQRRSHVPVAERLEGQLVSQQRSRLSQENQQFFLIPSQEQQDS 862
            |:.|.|||||              ..|||..|
Zfish   710 SNTVHPICLP--------------ATSHVFTA--------------------------------- 727

  Fly   863 STENQGDEDQDEQEDHFGGESAASYMPKAEALHQELDGYPLPDHAPQVNYYSSSSTVTSSSTAAR 927
                              |.|.                           :.:...|:....:||:
Zfish   728 ------------------GSSC---------------------------FVTGWGTLREGGSAAQ 747

  Fly   928 IATKAPILAAVPAAQEQIWTNCNTLGWSRQRDHLQRVQLKMGDMAPCENVSIATVNSMCMEATYQ 992
            |                                ||:.::|:.:...|..|:...|.|..|.:.|.
Zfish   748 I--------------------------------LQKAEVKVINDTVCNMVTEGQVTSRMMCSGYL 780

  Fly   993 K--YDCTQEEYSGAPVQCLIPGTNQWALIGVSSWRIACGPTGVERPRMYDKIASNAAWIRETIS 1054
            .  .|..|.: ||.|:.||..| .:|...|:.||...|...  .:|.:|.::.....||||..|
Zfish   781 SGGVDACQGD-SGGPLVCLSEG-GKWFQAGIVSWGEGCARR--NKPGVYTRVTKLREWIREITS 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1632	NP_001245577.1	SEA	232..327	CDD:279699	17/94 (18%)
		CRD_FZ	384..502	CDD:143549	27/176 (15%)
		PRKCSH-like	<503..>582	CDD:193472	30/119 (25%)
		LDLa	536..571	CDD:238060	13/34 (38%)
		Tryp_SPc	708..>809	CDD:304450	33/112 (29%)
zmp:0000001114	XP_685356.5	SEA	78..175	CDD:279699	22/116 (19%)
		CUB	208..322	CDD:238001	17/122 (14%)
		CUB	331..437	CDD:238001	19/105 (18%)
		LDLa	445..477	CDD:238060	10/31 (32%)
		LDLa	479..513	CDD:238060	13/34 (38%)
		LDLa	515..549	CDD:238060	6/35 (17%)
		LDLa	556..591	CDD:238060	6/55 (11%)
		Tryp_SPc	602..835	CDD:214473	67/360 (19%)
		Tryp_SPc	603..838	CDD:238113	70/362 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910