DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1632 and pik3r3

DIOPT Version :9

Sequence 1:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster
Sequence 2:	NP_001017229.1	Gene:	pik3r3 / 549983	XenbaseID:	XB-GENE-6464721	Length:	461	Species:	Xenopus tropicalis

Alignment Length:	205	Identity:	38/205 - (18%)
Similarity:	76/205 - (37%)	Gaps:	72/205 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 TQQRERERERDRDRERERERDRER-----DREREREHQLHMHQHNHGLRRKSESVLSTDSDIRFT 187
            ||:|..:...:|......|::.||     ::.:.|..::|            :|.|..:.|:
Frog   232 TQERYSKEYMERFNREGNEKEMERIIMNYEKLKSRLGEIH------------DSKLRLEQDL--- 281

  Fly   188 RRKLGDGQKCGCAVIAGFLIALLVAGIFVYVGYTYFRPEPLPDRVFRGRFMVLNDKWSMELANQN 252
            :::..|.::                   :.......:|:.:..|..|.:::|    |    .|..
Frog   282 KKQALDNRE-------------------IDKKMNSIKPDLIQLRKIRDQYLV----W----LNHK 319

  Fly   253 SMRFQHKARDYRERIN--LTLRRSDLREAYEGSEILALDGSEDNNNIVVHFNMIFDPYAGLVSSG 315
            .:|        ::|||  |.::..::.:.|..||       ||:|  :.|    :|.....|  |
Frog   320 GVR--------QKRINDWLGIKNENIDDTYFVSE-------EDDN--LPH----YDEKTWFV--G 361

  Fly   316 DLLALFHEEM 325
            ||..:..||:
Frog   362 DLNRIQAEEL 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1632	NP_001245577.1	SEA	232..327	CDD:279699	23/96 (24%)
		CRD_FZ	384..502	CDD:143549
		PRKCSH-like	<503..>582	CDD:193472
		LDLa	536..571	CDD:238060
		Tryp_SPc	708..>809	CDD:304450
pik3r3	NP_001017229.1	SH2_nSH2_p85_like	59..167	CDD:198195
		iSH2_PI3K_IA_R	172..332	CDD:355389	24/149 (16%)
		SH2_cSH2_p85_like	351..454	CDD:198184	8/27 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900