DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1632 and fzd7

DIOPT Version :9

Sequence 1:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster
Sequence 2:	NP_001016741.1	Gene:	fzd7 / 549495	XenbaseID:	XB-GENE-483731	Length:	548	Species:	Xenopus tropicalis

Alignment Length:	436	Identity:	97/436 - (22%)
Similarity:	128/436 - (29%)	Gaps:	181/436 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   385 CSPLELSYCRQVGYNITTYPNLLGHASYEQLAEDVIVFRELVDGECHREAYDFVCRLLQPPCDTH 449
            |.|:.:..|..:.||.|..||||||.:.|....:|..|..||..:|..|...|:|.:..|.|...
Frog    36 CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVL 100

  Fly   450 GSDLQPTPGQICREYCESFMAGC-------GGRLPQRFRQFFDCERFPESTGTQSCHQKPHCVSD 507
            ...:.|     ||..||....||       |.:.|:|.|    ||.||       .|
Frog   101 EQAIPP-----CRSLCERARQGCEALMNKFGFQWPERLR----CENFP-------IH-------- 141

  Fly   508 MQSNVQSPRLCDGYADCPDLSDERSCAFCSPNALYCGRGRACVPRKARCDGKADCPDGADEK--- 569
                                                |.|..||.:..    ..:.|.|...:
Frog   142 ------------------------------------GAGEICVGQNT----SDNSPSGPTARPTP 166

  Fly   570 ---DCLSIAP-LAADLLQPEPL--VPYLSRFHSAGYAVFSEKGVVGKLCAEGLEGDAKLVVRQTV 628
               |.::..| |..|...|..|  .|||      ||....||. .|..|..|
Frog   167 YLPDSITFHPHLNRDFTCPRQLKVPPYL------GYRFLGEKD-CGAPCEPG------------- 211

  Fly   629 SESLCKSLGYESVEIFDVQNDTERLNDYVRVLDPHAPEISFIRTHCPRRQVLYVGCGELRCGVQS 693
               ....|.|...|                       |:.|.|        |:||...:.||: |
Frog   212 ---KANGLMYFKEE-----------------------EVRFAR--------LWVGIWAILCGI-S 241

  Fly   694 ALFNAKQHL-SLPKMSAPGDWP--------WLVAL-----------------FREDIH--VCDGT 730
            .||....:| .:.:.|.| :.|        ::||:                 |.||.:  |..||
Frog   242 TLFTVLTYLVDMRRFSYP-ERPIIFLSGCYFMVAVAYTAGFLLEERGVCVERFSEDSYRTVAQGT 305

  Fly   731 LITQDWVLTTEGC--------FQGQPRATWMAIVGAV-RLSAKAPW 767
                    ..|||        |.|...:.|..|:... .|:|...|
Frog   306 --------KKEGCTILFMILYFFGMASSIWWVILSLTWFLAAGMKW 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1632	NP_001245577.1	SEA	232..327	CDD:279699
		CRD_FZ	384..502	CDD:143549	39/123 (32%)
		PRKCSH-like	<503..>582	CDD:193472	10/85 (12%)
		LDLa	536..571	CDD:238060	6/40 (15%)
		Tryp_SPc	708..>809	CDD:304450	21/96 (22%)
fzd7	NP_001016741.1	CRD_FZ7	32..156	CDD:143575	43/183 (23%)
		Frizzled	218..536	CDD:279827	35/167 (21%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	526..531
		PDZ-binding. /evidence=ECO:0000255	546..548
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910