DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1632 and Tmprss9

DIOPT Version :9

Sequence 1:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster
Sequence 2:	XP_006513905.2	Gene:	Tmprss9 / 432478	MGIID:	3612246	Length:	1342	Species:	Mus musculus

Alignment Length:	766	Identity:	152/766 - (19%)
Similarity:	231/766 - (30%)	Gaps:	311/766 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   366 GHDETTEPV-VTTTPAPPRRCSPLELSYCRQVGYNITTYPNLLGHASYEQLAEDVIVFRELVDGE 429
            ||.....|. ||.|...||.....:||....|..               :|.|.::.::  ....
Mouse   160 GHLRGWYPAQVTPTCGKPRPSLQAQLSSGSPVSL---------------KLCEALLCWK--AGTW 207

  Fly   430 CHREAYDFVCRLLQPPCDTHGSDLQ-------------PTPGQICRE----------------YC 465
            |...||  :||.::|.    ..|||             |.||. ||.                ..
Mouse   208 CLAGAY--LCRAMEPT----APDLQLVPEVTKAVSVSAPDPGP-CRTAVIAVVGISMAIVTLGVL 265

  Fly   466 ESFMAGCGGRLPQRFRQFFDCERFPESTG---TQSCHQK--------PHCVSDM-QSNVQSPRLC 518
            .:|.:..|..:          |...|..|   |.|..|:        .|.:..: .|:.|...|
Mouse   266 SAFFSAQGAHV----------EHIAELHGIRFTSSLQQENSDFYRLLTHALQTLFVSSFQKTEL- 319

  Fly   519 DGYADCPDLSDERSCAFCSPNALYCGRGRACVPRKARCDGKADCPDGADEKDCLSIAPLA----A 579
                       |.|||.|:..:...|.....|..:.....:|             :.||:    |
Mouse   320 -----------ESSCAGCTVLSYRDGNSTVIVHFRLHFLLRA-------------LQPLSLKQEA 360

  Fly   580 DLLQPEPLVPYLSRFHSAGYAVFSEKGVVGKLCAEGLEGDA-------KLVVR--QTVSESLCKS 635
            |:||                     ||:..:|..:||...|       :|..|  ..|:|...||
Mouse   361 DILQ---------------------KGIQARLQEQGLSLAAYGTIVSVELTGRCEGPVTERDLKS 404

  Fly   636 LGYESVEIFDVQNDTERLNDYVRVLDPHAPEISFIRTHCPRRQVLYVGC------GELRCGVQSA 694
             |:....:|..||.        :.:....||       |..|    |.|      .:..||.|.|
Mouse   405 -GHCPGNVFSCQNG--------QCVSKENPE-------CDDR----VDCSDESDEAQCDCGWQPA 449

  Fly   695 LFNAKQHLSLPKMSAPGDWPWLVALFREDIHVCDGTLITQDWVLTTEGCF-QGQPRATWMAIVGA 758
            ..:|.:.:...: :|||::||.|:|.....|.|..|:|...|:::...|| :.|..|.|.|..|:
Mouse   450 WRSAGRIVGGVE-AAPGEFPWQVSLRENHEHFCGATIIGARWLVSAAHCFNEFQDPAQWAAQAGS 513

  Fly   759 VRLSAKAPWTQRRRIIGMIKSPV-EGSTA----ALVRLETPVSYSDHVRPICLPDALQRRLLQQP 818
            |.||.......|.|::.:.|.|. :..||    |::.|..|:.:..:|:|.|||.|
Mouse   514 VHLSGSEASAVRTRVLRIAKHPAYDADTADFDVAVLELARPLPFGRYVQPACLPAA--------- 569

  Fly   819 PAQRRSHVPVAERLEGQLVSQQRSRLSQENQQFFLIPSQEQQDSSTENQGDEDQDEQEDHFGGES 883
                 :||
Mouse   570 -----THV--------------------------------------------------------- 572

  Fly   884 AASYMPKAEALHQELDGYPLPDHAPQVNYYSSSSTVTSSSTAARIATKAPILAAVPAAQEQIWTN 948
                             :|                                    |..:
Mouse   573 -----------------FP------------------------------------PGKK------ 578

  Fly   949 CNTLGWSRQRDH-------LQRVQLKMGDMAPCENV--SIATVNSMCMEATYQKYDCTQEEYSGA 1004
            |...||...::.       ||:..:::.|.:.|.::  ...|...:|......|.|..|.: ||.
Mouse   579 CLISGWGYLKEDFLVKPEVLQKATVELLDQSLCSSLYGHSLTDRMVCAGYLDGKVDSCQGD-SGG 642

  Fly  1005 PVQCLIPGTNQWALIGVSSWRIACGPTGVERPRMYDKIASNAAWIRETISA 1055
            |:.|..| :.::.|.|:.||.|.|..  ..||.:|.::.....||.|..||
Mouse   643 PLVCEEP-SGRFFLAGIVSWGIGCAE--ARRPGVYTRVTRLRDWILEVTSA 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1632	NP_001245577.1	SEA	232..327	CDD:279699
		CRD_FZ	384..502	CDD:143549	27/157 (17%)
		PRKCSH-like	<503..>582	CDD:193472	16/83 (19%)
		LDLa	536..571	CDD:238060	4/34 (12%)
		Tryp_SPc	708..>809	CDD:304450	36/106 (34%)
Tmprss9	XP_006513905.2	SEA	285..365	CDD:366610	21/125 (17%)
		LDLa	407..442	CDD:238060	9/53 (17%)
		Tryp_SPc	455..684	CDD:214473	67/363 (18%)
		Tryp_SPc	756..984	CDD:214473
		Tryp_SPc	1085..1336	CDD:238113
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834015
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930