DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1632 and mas

DIOPT Version :9

Sequence 1:	NP_001245577.1	Gene:	CG1632 / 31763	FlyBaseID:	FBgn0030027	Length:	1056	Species:	Drosophila melanogaster
Sequence 2:	NP_523919.1	Gene:	mas / 38499	FlyBaseID:	FBgn0011653	Length:	1047	Species:	Drosophila melanogaster

Alignment Length:	828	Identity:	151/828 - (18%)
Similarity:	243/828 - (29%)	Gaps:	328/828 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   357 PIMSSSPLGGHDETTEPVV--------TTTPAPPRRCSPLELSYCRQVGYNITTYPNLLGHASYE 413
            |..|:|..||..:....::        :.:|.||...:|:::..|
  Fly   414 PPSSTSGGGGGGDFLSQIISFAESTLNSPSPPPPPPQAPIQVPRC-------------------- 458

  Fly   414 QLAEDVIVFRELVDGECHREAYDFVCRLLQPPCDTHGSDLQPTP-----GQICREYCESFMAGC- 472
                         .|.|       :..::...|: ..|.|..||     |.:|   |::..||.
  Fly   459 -------------PGFC-------LLNIMAAFCE-RPSVLVSTPTTCAKGSVC---CDNSRAGAP 499

  Fly   473 GGRLPQRFRQFFDCERFPESTGTQSCHQKPHCVSDMQSNVQSPRLCDGYADCPDLSDERSCAF-- 535
            ..:||.           |..:.|.|....|:.:    .|..||   |...:||.     ||..
  Fly   500 KPKLPP-----------PTPSPTASPTAPPYVL----PNTPSP---DPREECPG-----SCIVSL 541

  Fly   536 ----CSPNA-----LYCGR-GRACVPRKARCDGKAD----------------------------- 561
                |..||     ..|.| |:.|...|::...|..
  Fly   542 LSFTCFKNAEMTDLFRCKRSGQICCAPKSKILEKQQFQTRNDTAYYPAPPPPPIGPPQAYPPQTP 606

  Fly   562 ------------------------------CPDGADEKDCLSIAPLAADLLQPEPLVPYLS---- 592
                                          .|:.||      ..|::...|.|:|..|..:
  Fly   607 PYSYMNNPPPQGPPPQMAPHHPNPYQPPPPAPNYAD------YYPVSGPGLPPQPQPPMTTPPTT 665

  Fly   593 -------RFHSAGYAVFSEKGVVGKLCAEGLE----GDAKLVVRQTVSESLCKSLGY-----ESV 641
                   |.|.....|...||.:....::.|.    ..||..|::| :..:..:.||     :|.
  Fly   666 TTTTTTPRPHVYSKYVCGVKGTLRTGRSQALSFVSYARAKYGVQRT-ARQMTSAAGYSPNFNKSN 729

  Fly   642 E-------IFDVQNDTERLNDYVRVLDPHAPEISFIRTH---CPRRQVLYVGCGELRC--GVQSA 694
            |       |..:|...::|.|.|......:.::.....|   ..:..::|....:.|.  |:||.
  Fly   730 ERLVLGSAIVPIQIHNDKLGDLVESSSLQSNQLRSYHNHQAQADQPDLVYPEYYQQRSLYGLQSN 794

  Fly   695 LFNAKQHLSL--PKMSAPGDWPWLVALFRE-DIHVCDGTLITQDWVLTTEGCFQGQPR---ATWM 753
             |:.::...:  .:....|:|.|.|||... :.::|...||...||||...|.....|   |.::
  Fly   795 -FSGRRRARVVGGEDGENGEWCWQVALINSLNQYLCGAALIGTQWVLTAAHCVTNIVRSGDAIYV 858

  Fly   754 AIVGAVRLSAK--APWTQRRRIIGMI-----KSPVEGSTAALVRLETPVSYSDHVRPICLPDALQ 811
            . ||...|:.|  :|..|..|:....     .|....:..||::|.......|.|..:||
  Fly   859 R-VGDYDLTRKYGSPGAQTLRVATTYIHHNHNSQTLDNDIALLKLHGQAELRDGVCLVCL----- 917

  Fly   812 RRLLQQPPAQRRSHVPVAERLEGQLVSQQRSRLSQENQQFFLIPSQEQQDSSTENQGDEDQDEQE 876
                   ||:..||           .:.:|..:
  Fly   918 -------PARGVSH-----------AAGKRCTV-------------------------------- 932

  Fly   877 DHFGGESAASYMPKAEALHQELDGYPLPDHAPQVNYYSSSSTVTSSSTAARIATKAPILAAVPAA 941
                  :...||.:|.         |:|....:                          |.:|..
  Fly   933 ------TGYGYMGEAG---------PIPLRVRE--------------------------AEIPIV 956

  Fly   942 QEQIWTNCNTLGWSRQRDHLQRVQLKMGDMAPCENVSIATVNSMCMEATYQKYDCTQEEYSGAPV 1006
            .:   |.|           :::|.      |..|.:.|...:|.|.... :.:|..|.: .|.|:
  Fly   957 SD---TEC-----------IRKVN------AVTEKIFILPASSFCAGGE-EGHDACQGD-GGGPL 999

  Fly  1007 QCLIPGTNQWALIGVSSWRIACGPTGVERPRMYDKIASNAAWIRETIS 1054
            .|...|.  :.|.|:.||...||...|  |.:|.|.:|...||.:.||
  Fly  1000 VCQDDGF--YELAGLVSWGFGCGRQDV--PGVYVKTSSFIGWINQIIS 1043

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1632	NP_001245577.1	SEA	232..327	CDD:279699
		CRD_FZ	384..502	CDD:143549	19/123 (15%)
		PRKCSH-like	<503..>582	CDD:193472	21/149 (14%)
		LDLa	536..571	CDD:238060	12/99 (12%)
		Tryp_SPc	708..>809	CDD:304450	31/111 (28%)
mas	NP_523919.1	Tryp_SPc	803..1041	CDD:238113	70/360 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24258
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100